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Sökning: WFRF:(Vaughan T. L.)

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1.
  • Grasby, KL, et al. (författare)
  • The genetic architecture of the human cerebral cortex
  • 2020
  • Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 367:6484, s. 1340-
  • Tidskriftsartikel (refereegranskat)
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2.
  • Abazov, V. M., et al. (författare)
  • Measurement of the top quark pair production cross section in the lepton plus jets channel in proton-antiproton collisions at root s=1.96 TeV
  • 2011
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 84:1, s. 012008-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present a measurement of the inclusive top quark pair production cross section in p (p) over bar collisions at root s = 1.96 TeV utilizing data corresponding to an integrated luminosity of 5.3 fb(-1) collected with the D0 detector at the Fermilab Tevatron Collider. We consider final states containing one high-p(T) isolated electron or muon and at least two jets, and we perform three analyses: one exploiting specific kinematic features of t (t) over bar events, the second using b-jet identification, and the third using both techniques to separate the t (t) over bar signal from the background. In the third case, we determine simultaneously the t (t) over bar cross section and the ratio of the production rates of W + heavy flavor jets and W + light flavor jets, which reduces the impact of the systematic uncertainties related to the background estimation. Assuming a top quark mass of 172.5 GeV, we obtain sigma(t (t) over bar) = 7.78(-0.64)(-0.77)pb. This result agrees with predictions of the standard model.
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4.
  • Abazov, M, et al. (författare)
  • Evidence of WW and WZ Production with lepton plus jets Final States in pp Collisions at root s=1.96 TeV
  • 2009
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:16, s. 161801-
  • Tidskriftsartikel (refereegranskat)abstract
    • We present first evidence for WW+WZ production in lepton+jets final states at a hadron collider. The data correspond to 1.07 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron in pp collisions at root s=1.96 TeV. The observed cross section for WW+WZ production is 20.2 +/- 4.5 pb, consistent with the standard model and more precise than previous measurements in fully leptonic final states. The probability that background fluctuations alone produce this excess is < 5.4x10(-6), which corresponds to a significance of 4.4 standard deviations.
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5.
  • Abazov, V. M., et al. (författare)
  • Muon reconstruction and identification with the Run II D0 detector
  • 2014
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 737, s. 281-294
  • Tidskriftsartikel (refereegranskat)abstract
    • We present an overview of the muon reconstruction and identification methods employed by the DO collaboration to analyze the Run II (2001-2011) p (p) over bar data of the Fermilab Tevatron collider at root s = 1.96 TeV. We discuss the performance of these methods, how it is measured using DO data, and how it is properly modeled by the DO simulation program. In its pseudorapidity acceptance, vertical bar eta vertical bar < 2, the muon system identifies high-p(T) muons (p(T) greater than or similar to 10 GeV) with efficiencies ranging from 72% to 89%. Muons tracks are reconstructed in the DO central tracking system with efficiencies ranging from 85% to 92% and with a typical relative momentum resolution of 10% for p(T) = 40 GeV. Isolation criteria reject multijet background with efficiencies of 87-99%.
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6.
  • Abazov, M, et al. (författare)
  • Search for Long-Lived Charged Massive Particles with the D0 Detector
  • 2009
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:16, s. 161802-
  • Tidskriftsartikel (refereegranskat)abstract
    • We search for long-lived charged massive particles using 1.1 fb(-1) of data collected by the D0 detector at the Fermilab Tevatron pp Collider. Time-of-flight information is used to search for pair produced long-lived tau sleptons, gauginolike charginos, and Higgsino-like charginos. We find no evidence of a signal and set 95% C.L. cross section upper limits for staus, which vary from 0.31 to 0.04 pb for stau masses between 60 and 300 GeV. We also set lower mass limits of 206 GeV (171 GeV) for pair produced charged gauginos (Higgsinos).
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8.
  • Ripke, Stephan, et al. (författare)
  • Biological insights from 108 schizophrenia-associated genetic loci
  • 2014
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 511:7510, s. 421-427
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
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9.
  • Feroci, M., et al. (författare)
  • The large observatory for x-ray timing
  • 2014
  • Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - 9780819496126
  • Konferensbidrag (refereegranskat)abstract
    • The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.
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10.
  • Marshall, Christian R., et al. (författare)
  • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
  • 2017
  • Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 49:1, s. 27-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 x 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 x 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 x 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
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