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> (2005-2009)
> Hoglund M >
Attitude towards re...
Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival.
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- Juliusson, Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Hälsouniversitetet,Onkologi,Hematologiska kliniken US
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- Billstrom, R (author)
- Universitetssjukhuset i Lund
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- Gruber, A (author)
- Karolinska universitetssjukhuset
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- Hellstrom-Lindberg, E (author)
- Karolinska universitetssjukhuset
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- Hoglund, M (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi,Akademiska sjukhuset i Uppsala
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- Karlsson, K (author)
- Hematologi Lunds universitet
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- Stockelberg, D (author)
- Sahlgrenska universitetssjukhuset
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- Wahlin, Anders (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Norrlands universitetssjukhus
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- Astrom, M (author)
- Universitetssjukhuset i Örebro
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- Arnesson, C (author)
- Universitetssjukhuset i Lund
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- Brunell-Abrahamsson, U (author)
- Akademiska sjukhuset i Uppsala
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- Carstensen, John, 1953- (author)
- Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle
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- Fredriksson, E (author)
- Karolinska universitetssjukhuset
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- Holmberg, E (author)
- Sahlgrenska universitetssjukhuset
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Nordenskjold, K (author)
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- Wiklund, F (author)
- Karolinska Institutet,Norrlands universitetssjukhus
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(creator_code:org_t)
- 2005-11-21
- 2006
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 20:1, s. 42-47
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Combination chemotherapy may induce remission from acute myeloid leukemia (AML), but validated criteria for treatment of elderly are lacking. The remission intention ( RI) rate for elderly patients, as reported to the Swedish Leukemia Registry, was known to be different when comparing the six health care regions, but the consequences of different management are unknown. The Leukemia Registry, containing 1672 AML patients diagnosed between 1997 and 2001, with 98% coverage and a median follow-up of 4 years, was completed with data from the compulsory cancer and population registries. Among 506 treated and untreated patients aged 70-79 years with AML (non-APL), there was a direct correlation between the RI rate in each health region ( range 36-76%) and the two-year overall survival, with no censored observations (6-21%) ( v 2 for trend = 11.3, P < 0.001; r(2) = 0.86, P < 0.02, nonparametric). A 1-month landmark analysis showed significantly better survival in regions with higher RI rates ( P = 0.003). Differences could not be explained by demographics, and was found in both de novo and secondary leukemias. The 5-year survival of the overall population aged 70-79 years was similar between the regions. Survival of 70-79-year-old AML patients is better in regions where more elderly patients are judged eligible for remission induction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- acute myeloid leukemia
- elderly
- remission induction
- population based
- palliation
- MEDICINE
- SOCIAL SCIENCES
Publication and Content Type
- art (subject category)
- ref (subject category)
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Leukemia
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- By the author/editor
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Juliusson, Gunna ...
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Billstrom, R
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Gruber, A
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Hellstrom-Lindbe ...
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Hoglund, M
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Karlsson, K
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Stockelberg, D
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Wahlin, Anders
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Astrom, M
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Arnesson, C
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Brunell-Abrahams ...
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Carstensen, John ...
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Fredriksson, E
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Holmberg, E
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Nordenskjold, K
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Wiklund, F
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia
- By the university
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Lund University
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Umeå University
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Uppsala University
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Karolinska Institutet
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Linköping University