Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Walker DA) "

Sökning: WFRF:(Walker DA)

Sortera/gruppera träfflistan
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Landes Bioscience. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
  • Aad, G., et al. (författare)
  • Measurement of the top pair production cross section in 8 TeV proton-proton collisions using kinematic information in the lepton plus jets final state with ATLAS
  • 2015
  • Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - : American Physical Society. - 1550-2368 .- 1550-7998. ; 91:11
  • Tidskriftsartikel (refereegranskat)abstract
    • A measurement is presented of the (tt) over bar inclusive production cross section in pp collisions at a center-ofmass energy of pffisffiffi root s = 8 TeV using data collected by the ATLAS detector at the CERN Large Hadron Collider. The measurement was performed in the lepton + jets final state using a data set corresponding to an integrated luminosity of 20.3 fb(-1). The cross section was obtained using a likelihood discriminant fit and b-jet identification was used to improve the signal-to-background ratio. The inclusive (tt) over bar production cross section was measured to be 260 +/- 1(stat)(-23)(+22)(stat) +/- 8(lumi) +/- 4(beam) pb assuming a top-quark mass of 172.5 GeV, in good agreement with the theoretical prediction of 253(-15)(+13) pb. The (tt) over bar -> (e, mu) + jets production cross section in the fiducial region determined by the detector acceptance is also reported.
  • Mitchell, Jonathan S., et al. (författare)
  • Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
  • 2016
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723 .- 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
  • Winkler, Thomas W, et al. (författare)
  • The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
  • 2015
  • Ingår i: PLoS Genetics. - : Public Library of Science. - 1553-7404 .- 1553-7390. ; 11:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
  • Aad, G., et al. (författare)
  • A search for new physics in dijet mass and angular distributions in pp collisions at root s=7 TeV measured with the ATLAS detector
  • 2011
  • Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 13
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb(-1), dijet mass and angular distributions were measured up to dijet masses of similar to 3.5 TeV and were found to be in good agreement with Standard Model predictions. This analysis sets limits at 95% CL on various models for new physics: an excited quark is excluded for mass between 0.60 and 2.64 TeV, an axigluon hypothesis is excluded for axigluon masses between 0.60 and 2.10 TeV and quantum black holes are excluded in models with six extra space-time dimensions for quantum gravity scales between 0.75 and 3.67 TeV. Production cross section limits as a function of dijet mass are set using a simplified Gaussian signal model to facilitate comparisons with other hypotheses. Analysis of the dijet angular distribution using a novel technique simultaneously employing the dijet mass excludes quark contact interactions with a compositeness scale 3 below 9.5 TeV.
  • Aad, G., et al. (författare)
  • Inclusive search for same-sign dilepton signatures in pp collisions at root s=7 TeV with the ATLAS detector
  • 2011
  • Ingår i: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :10
  • Tidskriftsartikel (refereegranskat)abstract
    • An inclusive search is presented for new physics in events with two isolated leptons (e or mu) having the same electric charge. The data are selected from events collected from p p collisions at root s = 7 TeV by the ATLAS detector and correspond to an integrated luminosity of 34 pb(-1). The spectra in dilepton invariant mass, missing transverse momentum and jet multiplicity are presented and compared to Standard Model predictions. In this event sample, no evidence is found for contributions beyond those of the Standard Model. Limits are set on the cross-section in a fiducial region for new sources of same-sign high-mass dilepton events in the ee, e mu and mu mu channels. Four models predicting same-sign dilepton signals are constrained: two descriptions of Majorana neutrinos, a cascade topology similar to supersymmetry or universal extra dimensions, and fourth generation d-type quarks. Assuming a new physics scale of 1 TeV, Majorana neutrinos produced by an effective operator V with masses below 460 GeV are excluded at 95% confidence level. A lower limit of 290 GeV is set at 95% confidence level on the mass of fourth generation d-type quarks.
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (541)
forskningsöversikt (9)
konferensbidrag (1)
Typ av innehåll
refereegranskat (546)
övrigt vetenskapligt (5)
Aad, G (565)
Zwalinski, L. (508)
Chen, H. (470)
Chen, X. (470)
Francis, D. (467)
Kobayashi, T. (467)
visa fler...
Blumenschein, U. (466)
Esposito, B. (466)
Ferrer, A. (466)
Fleck, I. (466)
Ishino, M. (466)
Antonelli, M. (465)
Bella, G. (465)
Benekos, N. (465)
Bentvelsen, S. (465)
Boonekamp, M. (465)
Busato, E. (465)
Butler, J. M. (465)
Calderini, G. (465)
Caron, S. (465)
Cheu, E. (465)
Chevalier, L. (465)
Cowan, G. (465)
Cranmer, K. (465)
Dallapiccola, C. (465)
Eigen, G. (465)
Ekelof, T. (465)
Etzion, E. (465)
Evans, H. (465)
Fassouliotis, D. (465)
Ferrari, A. (465)
Fournier, D. (465)
Fox, H. (465)
Fukunaga, C. (465)
Garcia, C. (465)
Gross, E. (465)
Haas, A. (465)
Hamacher, K. (465)
Hasegawa, Y. (465)
Hauser, R. (465)
Hirose, M. (465)
Hou, S. (465)
Hughes, G. (465)
Jakobs, K. (465)
Kawagoe, K. (465)
Kawamoto, T. (465)
Kehoe, R. (465)
Kourkoumelis, C. (465)
Kupco, A. (465)
Leggett, C. (465)
visa färre...
Lunds universitet (483)
Kungliga Tekniska Högskolan (410)
Karolinska Institutet (51)
Uppsala universitet (30)
Stockholms universitet (20)
Umeå universitet (11)
visa fler...
Göteborgs universitet (8)
Örebro universitet (4)
Linköpings universitet (4)
Chalmers tekniska högskola (2)
Karlstads universitet (1)
visa färre...
Engelska (551)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (487)
Medicin och hälsovetenskap (39)
Teknik (1)
Lantbruksvetenskap (1)


pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy