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Characteristics and...
Characteristics and outcomes of atrial fibrillation in patients without traditional risk factors : an RE-LY AF registry analysis
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- Kloosterman, Marielle (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
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- Oldgren, Jonas, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Conen, David (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Wong, Jorge A. (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Connolly, Stuart J. (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Avezum, Alvaro (author)
- Dante Pazzanese Inst Cardiol, Div Cardiol, Sao Paulo, Brazil.
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- Yusuf, Salim (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Ezekowitz, Michael D. (author)
- Med Coll & Lankenau Med Ctr, Dept Med, Wynnewood, PA USA.
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Ntep-Gweth, Marie (author)
- Hop Cent Yaounde, Dept Med, Yaounde, Cameroon.
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- Joseph, Philip (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Barrett, Tyler W. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
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- Tanosmsup, Supachai (author)
- Mahidol Univ, Dept Med, Bangkok, Thailand.
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- McIntyre, William F. (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Lee, Shun Fu (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Parkash, Ratika (author)
- Queen Elizabeth 2 Hlth Sci Ctr, Dept Med, Halifax, NS, Canada.;Dalhousie Univ, Halifax, NS, Canada.
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- Amit, Guy (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Grinvalds, Alex (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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- Van Gelder, Isabelle C. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
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- Healey, Jeff S. (author)
- McMaster Univ, Populat Hlth Res Inst, Dept Med, 30 Birge St,Room C3-121, Hamilton, ON L8L 0A6, Canada.
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Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands Kardiologi (creator_code:org_t)
- 2020-03-26
- 2020
- English.
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 22:6, s. 870-877
- Related links:
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https://pure.rug.nl/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Aims: Data on patient characteristics, prevalence, and outcomes of atrial fibrillation (AF) patients without traditional risk factors, often labelled 'lone AF', are sparse. Methods and results: The RE-LY AF registry included 15 400 individuals who presented to emergency departments with AF in 47 countries. This analysis focused on patients without traditional risk factors, including age >= 60years, hypertension, coronary artery disease, heart failure, left ventricular hypertrophy, congenital heart disease, pulmonary disease, valve heart disease, hyperthyroidism, and prior cardiac surgery. Patients without traditional risk factors were compared with age- and region-matched controls with traditional risk factors (1:3 fashion). In 796 (5%) patients, no traditional risk factors were present. However, 98% (779/796) had less-established or borderline risk factors, including borderline hypertension (130-140/80-90mmHg; 47%), chronic kidney disease (eGFR<60mL/min; 57%), obesity (body mass index>30; 19%), diabetes (5%), excessive alcohol intake (>14 units/week; 4%), and smoking (25%). Compared with patients with traditional risk factors (n=2388), patients without traditional risk factors were more often men (74% vs. 59%, P<0.001) had paroxysmal AF (55% vs. 37%, P<0.001) and less AF persistence after 1 year (21% vs. 49%, P<0.001). Furthermore, 1-year stroke occurrence rate (0.6% vs. 2.0%, P=0.013) and heart failure hospitalizations (0.9% vs. 12.5%, P<0.001) were lower. However, risk of AF-related re-hospitalization was similar (18% vs. 21%, P=0.09). Conclusion: Almost all patients without traditionally defined AF risk factors have less-established or borderline risk factors. These patients have a favourable 1-year prognosis, but risk of AF-related re-hospitalization remains high. Greater emphasis should be placed on recognition and management of less-established or borderline risk factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Substrate
- Less-established risk factors
- Borderline risk factors
- Atrial fibrillation hospitalization
- Lone atrial fibrillation
- Registry
Publication and Content Type
- ref (subject category)
- art (subject category)
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Europace
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Kloosterman, Mar ...
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Oldgren, Jonas, ...
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Conen, David
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Wong, Jorge A.
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Connolly, Stuart ...
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Avezum, Alvaro
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Yusuf, Salim
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Ezekowitz, Micha ...
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Wallentin, Lars, ...
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Ntep-Gweth, Mari ...
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Joseph, Philip
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Barrett, Tyler W ...
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Tanosmsup, Supac ...
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McIntyre, Willia ...
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Lee, Shun Fu
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Parkash, Ratika
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Amit, Guy
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Grinvalds, Alex
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Van Gelder, Isab ...
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Healey, Jeff S.
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- MEDICAL AND HEALTH SCIENCES
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Europace
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Uppsala University