Search: WFRF:(Wallentin Lars C. 1943 )
> (2020-2022)
> (2021)
> Holleczek Bernd >
Meta-analysis uncov...
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
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- Gorski, Mathias (author)
- University Hospital Regensburg,University of Regensburg
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Jung, Bettina (author)
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Li, Yong (author)
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show more...
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Matias-Garcia, Pamela R. (author)
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Wuttke, Matthias (author)
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Coassin, Stefan (author)
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Thio, Chris H. L. (author)
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Kleber, Marcus E. (author)
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Winkler, Thomas W. (author)
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Wanner, Veronika (author)
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Chai, Jin-Fang (author)
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Chu, Audrey Y. (author)
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Cocca, Massimiliano (author)
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Feitosa, Mary F. (author)
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Ghasemi, Sahar (author)
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Hoppmann, Anselm (author)
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Horn, Katrin (author)
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Li, Man (author)
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Nutile, Teresa (author)
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Scholz, Markus (author)
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Sieber, Karsten B. (author)
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Teumer, Alexander (author)
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Tin, Adrienne (author)
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Wang, Judy (author)
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Tayo, Bamidele O. (author)
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Ahluwalia, Tarunveer S. (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease,Cardiovascular Research - Hypertension
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Bakker, Stephan J. L. (author)
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Banas, Bernhard (author)
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Bansal, Nisha (author)
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Biggs, Mary L. (author)
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Boerwinkle, Eric (author)
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Bottinger, Erwin P. (author)
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Brenner, Hermann (author)
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Carroll, Robert J. (author)
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Chalmers, John (author)
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Chee, Miao-Li (author)
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Chee, Miao-Ling (author)
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Cheng, Ching-Yu (author)
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Coresh, Josef (author)
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de Borst, Martin H. (author)
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Degenhardt, Frauke (author)
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Eckardt, Kai-Uwe (author)
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Endlich, Karlhans (author)
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Franke, Andre (author)
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Freitag-Wolf, Sandra (author)
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Gampawar, Piyush (author)
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Gansevoort, Ron T. (author)
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Ghanbari, Mohsen (author)
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Gieger, Christian (author)
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Hamet, Pavel (author)
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Ho, Kevin (author)
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Hofer, Edith (author)
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Holleczek, Bernd (author)
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Xian Foo, Valencia Hui (author)
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Hutri-Kähönen, Nina (author)
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Hwang, Shih-Jen (author)
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Ikram, M. Arfan (author)
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Josyula, Navya Shilpa (author)
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Kähönen, Mika (author)
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Khor, Chiea-Chuen (author)
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Koenig, Wolfgang (author)
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Kramer, Holly (author)
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Krämer, Bernhard K. (author)
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Kühnel, Brigitte (author)
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Lange, Leslie A. (author)
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Lehtimäki, Terho (author)
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Lieb, Wolfgang (author)
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Loos, Ruth J. F. (author)
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Lukas, Mary Ann (author)
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Lyytikäinen, Leo-Pekka (author)
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Meisinger, Christa (author)
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Meitinger, Thomas (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Milaneschi, Yuri (author)
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Mishra, Pashupati P. (author)
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Mononen, Nina (author)
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Mychaleckyj, Josyf C. (author)
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Nadkarni, Girish N. (author)
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Nauck, Matthias (author)
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Nikus, Kjell (author)
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Ning, Boting (author)
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Nolte, Ilja M. (author)
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O'Donoghue, Michelle L. (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Pendergrass, Sarah A. (author)
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Penninx, Brenda W. J. H. (author)
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Preuss, Michael H. (author)
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Psaty, Bruce M. (author)
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Raffield, Laura M. (author)
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Raitakari, Olli T. (author)
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Rettig, Rainer (author)
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Rheinberger, Myriam (author)
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Rice, Kenneth M. (author)
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Rosenkranz, Alexander R. (author)
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Rossing, Peter (author)
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Rotter, Jerome I. (author)
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Sabanayagam, Charumathi (author)
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Schmidt, Helena (author)
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Schmidt, Reinhold (author)
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Schöttker, Ben (author)
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Schulz, Christina-Alexandra (author)
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Sedaghat, Sanaz (author)
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Shaffer, Christian M. (author)
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Strauch, Konstantin (author)
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Szymczak, Silke (author)
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Taylor, Kent D. (author)
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Tremblay, Johanne (author)
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Chaker, Layal (author)
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van der Harst, Pim (author)
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van der Most, Peter J. (author)
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Verweij, Niek (author)
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Völker, Uwe (author)
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Waldenberger, Melanie (author)
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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Waterworth, Dawn M. (author)
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White, Harvey D. (author)
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Wilson, James G. (author)
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Wong, Tien-Yin (author)
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Woodward, Mark (author)
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Yang, Qiong (author)
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Yasuda, Masayuki (author)
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Yerges-Armstrong, Laura M. (author)
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Zhang, Yan (author)
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Snieder, Harold (author)
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Wanner, Christoph (author)
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Böger, Carsten A. (author)
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Köttgen, Anna (author)
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Kronenberg, Florian (author)
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Pattaro, Cristian (author)
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- Heid, Iris M. (author)
- University of Regensburg
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(creator_code:org_t)
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- Elsevier, 2021
- 2021
- English.
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In: Kidney International. - : Elsevier. - 0085-2538 .- 1523-1755. ; 99:4, s. 926-939
- Related links:
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https://doi.org/10.1...
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show more...
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https://uu.diva-port... (primary) (Raw object)
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http://www.kidney-in...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Genome-wide association study
- acute kidney injury
- end-stage kidney disease
- rapid eGFRcrea decline
- Genome-wide association study; acute kidney injury; end-stage kidney disease; rapid eGFRcrea decline.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gorski, Mathias
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Jung, Bettina
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Li, Yong
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Matias-Garcia, P ...
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Wuttke, Matthias
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Coassin, Stefan
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show more...
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Thio, Chris H. L ...
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Kleber, Marcus E ...
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Winkler, Thomas ...
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Wanner, Veronika
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Chai, Jin-Fang
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Chu, Audrey Y.
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Cocca, Massimili ...
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Feitosa, Mary F.
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Ghasemi, Sahar
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Hoppmann, Anselm
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Horn, Katrin
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Li, Man
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Nutile, Teresa
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Scholz, Markus
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Sieber, Karsten ...
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Teumer, Alexande ...
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Tin, Adrienne
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Wang, Judy
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Tayo, Bamidele O ...
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Ahluwalia, Tarun ...
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Almgren, Peter
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Bakker, Stephan ...
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Banas, Bernhard
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Bansal, Nisha
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Biggs, Mary L.
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Boerwinkle, Eric
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Bottinger, Erwin ...
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Brenner, Hermann
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Carroll, Robert ...
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Chalmers, John
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Chee, Miao-Li
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Chee, Miao-Ling
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Cheng, Ching-Yu
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Coresh, Josef
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de Borst, Martin ...
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Degenhardt, Frau ...
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Eckardt, Kai-Uwe
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Endlich, Karlhan ...
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Franke, Andre
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Freitag-Wolf, Sa ...
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Gampawar, Piyush
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Gansevoort, Ron ...
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Ghanbari, Mohsen
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Gieger, Christia ...
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Hamet, Pavel
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Ho, Kevin
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Hofer, Edith
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Holleczek, Bernd
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Xian Foo, Valenc ...
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Hutri-Kähönen, N ...
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Hwang, Shih-Jen
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Ikram, M. Arfan
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Josyula, Navya S ...
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Kähönen, Mika
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Khor, Chiea-Chue ...
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Koenig, Wolfgang
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Kramer, Holly
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Krämer, Bernhard ...
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Kühnel, Brigitte
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Lange, Leslie A.
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Lehtimäki, Terho
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Lieb, Wolfgang
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Loos, Ruth J. F.
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Lukas, Mary Ann
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Lyytikäinen, Leo ...
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Meisinger, Chris ...
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Meitinger, Thoma ...
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Melander, Olle
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Milaneschi, Yuri
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Mishra, Pashupat ...
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Mononen, Nina
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Mychaleckyj, Jos ...
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Nadkarni, Girish ...
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Nauck, Matthias
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Nikus, Kjell
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Ning, Boting
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Nolte, Ilja M.
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O'Donoghue, Mich ...
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Orho-Melander, M ...
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Pendergrass, Sar ...
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Penninx, Brenda ...
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Preuss, Michael ...
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Psaty, Bruce M.
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Raffield, Laura ...
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Raitakari, Olli ...
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Rettig, Rainer
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Rheinberger, Myr ...
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Rice, Kenneth M.
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Rosenkranz, Alex ...
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Rossing, Peter
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Rotter, Jerome I ...
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Sabanayagam, Cha ...
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Schmidt, Helena
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Schmidt, Reinhol ...
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Schöttker, Ben
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Schulz, Christin ...
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Sedaghat, Sanaz
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Shaffer, Christi ...
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Strauch, Konstan ...
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Szymczak, Silke
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Taylor, Kent D.
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Tremblay, Johann ...
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Chaker, Layal
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van der Harst, P ...
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van der Most, Pe ...
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Verweij, Niek
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Völker, Uwe
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Waldenberger, Me ...
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Wallentin, Lars, ...
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Waterworth, Dawn ...
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White, Harvey D.
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Wilson, James G.
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Wong, Tien-Yin
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Woodward, Mark
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Yang, Qiong
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Yasuda, Masayuki
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Yerges-Armstrong ...
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Zhang, Yan
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Snieder, Harold
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Wanner, Christop ...
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Böger, Carsten A ...
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Köttgen, Anna
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Kronenberg, Flor ...
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Pattaro, Cristia ...
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Heid, Iris M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Kidney Internati ...
- By the university
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Uppsala University
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Lund University