| 1. |
- He, Chao, et al.
(författare)
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A clinical study of high-dose urokinase for the treatment of the patients with hypertension induced ventricular hemorrhage
- 2021
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Ingår i: Brain protection strategies and nanomedicine. - : Elsevier BV. - 9780323989275 ; , s. 349-355
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Bokkapitel (refereegranskat)abstract
- Objective: This study discusses the therapeutic effect of high-dose urokinase treatment for hypertension ventricular hemorrhage.Methods: A total of 60 patients with hypertension ventricular hemorrhage were randomly assigned to two groups: treatment group (n = 30)and control group (n = 30). Both groups received bilateral external ventricular drain. The treatment group was injected with 50,000 IU urokinase to the lateral ventricle every day; the total injection volume per day was 100,000 IU. The control group was injected with 20,000 IU urokinase to the lateral ventricle every day with a total injection volume per day of 40,000 IU. Lumbar puncture was performed in both groups after the later ventricular drain was removed to release cerebrospinal fluid (CSF). Head Computed tomography(CT) examination was performed regularly to observe changes in the ventricular hematoma as well as the occurrence of complications such as intracranial infection and hydrocephalus. Patient prognosis 6 weeks after surgery was compared between the two groups.Results: In the treatment group, the intraventricular hemorrhage clearance time and the number of instances of urokinase treatment were significantly less than those of the control group (P<0.05). The total urokinase dosage of the treatment group was significantly higher than that of the control group (P<0.05). With respect to post-surgery complications, in the treatment group, there were three cases of hydrocephalus and one case of intracranial infection. In the control group, there were four cases of hydrocephalus and three cases of intracranial infection. Intraventricular re-hemorrhage was not observed in either group. Intracranial infection was relieved after strengthened anti-infective therapy and continuous drainage. There was a statistically significant difference in the occurrence of complications between the treatment group and the control group (P<0.05). The rate of good prognosis in the treatment group was higher than that of the control group (P<0.05), and the inefficiency rate was lower (P<0.05).Conclusions: High-dose urokinase treatment produces a significant therapeutic effect in hypertension ventricular hemorrhage. This treatment can quickly eliminate intraventricular hemorrhage, shorten the ventricular drain tube indwelling time, decrease the occurrence of intracranial infection, and increase the likelihood of a good prognosis.
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| 2. |
- Li, Gang, et al.
(författare)
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Quantum Spin Hall States in 2D Bismuth-Based Materials
- 2019
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Ingår i: Springer Series in Materials Science. - Singapore : Springer Singapore. - 2196-2812 .- 0933-033X. ; 285, s. 351-379
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Berrys phase, an inherent constituent of the electronic wave functions, has revolutionarily enriched our understanding of the fundamental states of matter and has triggered the discovery of many interesting phenomena in condensed matter physics, such as quantum charge/spin pumping, polarization, topological insulating phase, etc. Among them, the discovery of the two-dimensional (2D) quantum spin Hall (QSH) states protected by time-reversal symmetry (TRS) boosts the wide interest in the study of topological materials in the past decade. These include the 2D quantum anomalous Hall states (QAH), three-dimensional topological insulators (TIs), Dirac semimetals (SM), and topological nodal-line SMs as well as Weyl SMs. This article by no means can cover everything of this rapidly developing field, we rather focus on the bismuth-based honeycomb materials hosting large-gap QSH/QAH states, which promise applications for room-temperature spintronic. We will explain their topological mechanisms in terms of Berrys phase and topological invariant. After introducing a concrete material example which has been successfully grown in experiment, e.g., Bi/SiC(0001), various theoretical proposals on atom substitution and functionalization based on bismuth honeycomb lattice will then be discussed, from which a general designing principle for achieving large topological gaps can be summarized. This article hopes to stimulate more experimental activities toward the examination of large-gap QSH/QAH theoretical proposals and the potential applications in spintronic devices.
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| 3. |
- Zhang, Wei, et al.
(författare)
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Surgical treatment of low-grade brain tumors associated with epilepsy
- 2020
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Ingår i: NOVEL THERAPEUTIC ADVANCES IN GLIOBLASTOMA. - LONDON ENGLAND : Elsevier. - 9780128211144 ; , s. 171-183
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Bokkapitel (refereegranskat)abstract
- Objective: To explore the strategy of surgical treatment of low-grade brain tumors associated with epilepsy. Methods: Clinical data of 158 patients with low-grade brain tumors were collected from January 2011 to December 2017 in Guangdong Sanjiu brain hospital. All patients received Preoperative evaluation. Lesion site: 18 cases were located in multiple cerebral lobes, 10 cases were in the functional zones, 130 cases were in the non-functional zones (including 74 cases were in the medial of temporal lobe). The surgical strategy included subtotal resection, gross-total resection and enlarged resection. Postoperative effects were evaluated by Engel classification. Results: A total of 158 patients underwent surgical treatment, among these patients, only 1 patient underwent intracranial electrode implantation. Surgical methods: 34 cases of subtotal resection, 3 cases of gross-total resection, 119 cases of enlarged resection (including Anterior temporal lobectomy in 74 cases) and 2 case of Selective hippocampal amygdalectomy. The final pathology suggested that there are 74 cases of ganglionglioma, 25 cases of dysembryoplastic neuroepithelial tumors, 9 cases of pilocytic astrocytoma, 16 cases of oligodendroglioma, 10 cases of pleomorphic xanthoastrocytoma, 4 case of diffuse astrocytoma, 9 cases of unclassified astrocytoma, 11 case of oligoastrocytoma. The follow-up time was between 1 and 7 years, with an average of 3.44 +/- 1.77 years. Postoperative recovery: 147 patients had an Engel Class I outcome, 10 patients were in Engel Class II, 1 patient was in Class IV. Conclusion: The strategy of surgical treatment of low-grade brain tumors associated with epilepsy should pay more attention to the preoperative assessment of the epileptogenic zone. The tumor is not exactly the same as the epileptogenic zone, and the strategy of surgical treatment depends on the tumor feature as well as whether it was located in temporal lobe or involved in functional areas.
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