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Sökning: WFRF:(Wang Gang) > Xu Feng

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  • Jin, Ying-Hui, et al. (författare)
  • Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19 : An evidence-based clinical practice guideline (updated version)
  • 2020
  • Ingår i: Military Medical Research. - : Springer Science and Business Media LLC. - 2054-9369. ; 7:1
  • Tidskriftsartikel (refereegranskat)abstract
    • The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued "A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)"; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis (including agents and Traditional Chinese Medicine (TCM) agents), diagnosis (including clinical manifestations, reverse transcription-polymerase chain reaction (RT-PCR), respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest x-ray, and CT features of asymptomatic infections), treatments (including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, qingfei paidu decoction, lianhua qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation (ECMO)), and discharge management (including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge). We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.
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3.
  • Xu, Shuang Feng, et al. (författare)
  • Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice
  • 2019
  • Ingår i: Redox Biology. - : Elsevier BV. - 2213-2317. ; 21
  • Tidskriftsartikel (refereegranskat)abstract
    • Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators have been investigated for their ability to prevent neurodegenerative diseases with features of iron overload. Given the non-trivial side effects of classical iron chelators, lactoferrin (Lf), a multifunctional iron-binding globular glycoprotein, was screened to identify novel neuroprotective pathways against dopaminergic neuronal impairment. We found that Lf substantially ameliorated PD-like motor dysfunction in the subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. We further showed that Lf could alleviate MPTP-triggered apoptosis of DA neurons, neuroinflammation, and histological alterations. As expected, we also found that Lf suppressed MPTP-induced excessive iron accumulation and the upregulation of divalent metal transporter (DMT1) and transferrin receptor (TFR), which is the main intracellular iron regulation protein, and subsequently improved the activity of several antioxidant enzymes. We probed further and determined that the neuroprotection provided by Lf was involved in the upregulated levels of brain-derived neurotrophic factor (BDNF), hypoxia-inducible factor 1α (HIF-1α) and its downstream protein, accompanied by the activation of extracellular regulated protein kinases (ERK) and cAMP response element binding protein (CREB), as well as decreased phosphorylation of c-Jun N-terminal kinase (JNK) and mitogen activated protein kinase (MAPK)/P38 kinase in vitro and in vivo. Our findings suggest that Lf may be an alternative safe drug in ameliorating MPTP-induced brain abnormalities and movement disorder.
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4.
  • Wang, Tianheng, et al. (författare)
  • A combinatoric shortcut to evaluate CHY-forms
  • 2017
  • Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; :6
  • Tidskriftsartikel (refereegranskat)abstract
    • In our recent work, we proposed a differential operator for the evaluation of the multi-dimensional residues on isolated (zero-dimensional) poles. In this paper we discuss some new insight on evaluating the (generalized) Cachazo-He-Yuan (CHY) forms of the scattering amplitudes using this differential operator. We introduce a tableau representation for the coefficients appearing in the proposed differential operator. Combining the tableaux with the polynomial form of the scattering equations, the evaluation of the generalized CHY form becomes a simple combinatoric problem. It is thus possible to obtain the coefficients arising in the differential operator in a straightforward way. We present the procedure for a complete solution of the n-gon amplitudes at one-loop level in a generalized CHY form. We also apply our method to fully evaluate the one-loop five-point amplitude in the maximally supersymmetric Yang-Mills theory; the final result is identical to the one obtained by Q-Cut.
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5.
  • Wang, Tianheng, et al. (författare)
  • A differential operator for integrating one-loop scattering equations
  • 2017
  • Ingår i: Journal of High Energy Physics (JHEP). - : SPRINGER. - 1126-6708 .- 1029-8479. ; :1
  • Tidskriftsartikel (refereegranskat)abstract
    • We propose a differential operator for computing the residues associated with a class of meromorphic n-forms that frequently appear in the Cachazo-He-Yuan form of the scattering amplitudes. This differential operator is conjectured to be uniquely determined by the local duality theorem and the intersection number of the divisors in the n-form. We use the operator to evaluate the one-loop integrand of Yang-Mills theory from their generalized CHY formulae. The method can reduce the complexity of the calculation. In addition, the expression for the 1-loop four-point Yang-Mills integrand obtained in our approach has a clear correspondence with the Q-cut results.
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