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Sökning: WFRF:(Wang Gang) > Zhang Lin

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2.
  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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3.
  • Zhang, Lin, et al. (författare)
  • Decentralized Caching Schemes and Performance Limits in Two-Layer Networks
  • 2018
  • Ingår i: IEEE Transactions on Vehicular Technology. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0018-9545 .- 1939-9359. ; 67:12, s. 12177-12192
  • Tidskriftsartikel (refereegranskat)abstract
    • We study the decentralized caching scheme in a two-layer network, which includes a server, multiple helpers, and multiple users. Basically, the proposed caching scheme consists of two phases, i.e., placement phase and delivery phase. In the placement phase, each helper/user randomly and independently selects contents from the server and stores them into its memory. In the delivery phase, the users request contents from the server, and the server satisfies each user through a helper. Different from the existing caching scheme, the proposed caching scheme takes into account the pre- stored contents at both helpers and users in the placement phase to design the delivery phase. Meanwhile, the proposed caching scheme exploits index coding in the delivery phase and leverages multicast opportunities, even when different users request distinct contents. Besides, we analytically characterize the performance limit of the proposed caching scheme, and show that the achievable rate region of the proposed caching scheme lies within constant margins to the information-theoretic optimum. In particular, the multiplicative and additive factors are carefully sharpened to be 1/48 and 4, respectively, both of which are better than the state of arts. Finally, simulation results demonstrate the advantage of the proposed caching scheme compared with the state of arts.
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4.
  • Zhang, Lin, et al. (författare)
  • Order-Optimal Caching in Hierarchical Networks
  • 2016
  • Ingår i: 2016 IEEE/CIC INTERNATIONAL CONFERENCE ON COMMUNICATIONS IN CHINA (ICCC). - : IEEE.
  • Konferensbidrag (refereegranskat)abstract
    • The decentralized caching is studied in hierarchical networks, where users request contents through intermediate nodes (helpers) from a file server. By placing contents randomly and independently in each node and carefully designing the data delivery, the correlations of the pre-stored contents across layers can be utilized to reduce the transmission rate in each layer. A hybrid caching scheme is developed by exploiting the cross-layer storage correlations as well as the single-layer and cross-layer multicast opportunities. It is observed that the achievable rate region of the hybrid caching scheme is strictly better than the caching scheme in [1]. Furthermore, the order-optimality of the hybrid caching scheme is demonstrated by achieving the performance within constant multiplicative and additive factors of the information-theoretic optimum. In particular, the multiplicative and additive factors are carefully quantified to be 1/48 and 4, respectively.
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  • Resultat 1-4 av 4

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