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Träfflista för sökning "WFRF:(Wang Yongjun) ;lar1:(liu)"

Sökning: WFRF:(Wang Yongjun) > Linköpings universitet

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  • Wang, Peng, et al. (författare)
  • Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray
  • 2016
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 113:32, s. E4726-E4735
  • Tidskriftsartikel (refereegranskat)abstract
    • The neuropeptide galanin coexists in rat brain with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus (LC), and it has been suggested to be involved in depression. We studied rats exposed to chronic mild stress (CMS), a rodent model of depression. As expected, these rats showed several endophenotypes relevant to depression-like behavior compared with controls. All these endophenotypes were normalized after administration of a selective serotonin reuptake inhibitor. The transcripts for galanin and two of its receptors, galanin receptor 1 (GALR1) and GALR2, were analyzed with quantitative real-time PCR using laser capture microdissection in the following brain regions: the hippocampal formation, LC, and ventral periaqueductal gray (vPAG). Only Galr1 mRNA levels were significantly increased, and only in the latter region. After knocking down Galr1 in the vPAG with an siRNA technique, all parameters of the depressive behavioral phenotype were similar to controls. Thus, the depression-like behavior in rats exposed to CMS is likely related to an elevated expression of Galr1 in the vPAG, suggesting that a GALR1 antagonist could have antidepressant effects.
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3.
  • Yang, Jinghai, et al. (författare)
  • Investigation on the origin of green light emission in ZnO bulk materials
  • 2009
  • Ingår i: INTERNATIONAL JOURNAL OF MATERIALS and PRODUCT TECHNOLOGY. - 0268-1900. ; 34:3, s. 360-368
  • Tidskriftsartikel (refereegranskat)abstract
    • ZnO bulk materials were implanted by O and Zn with different concentration and their photoluminescence (PL) properties were investigated in detail. The results clearly show that O and Zn implantation indeed have great influence on the green light emission. By comparing the PL spectra for the samples with different implantations, O-i, Zn-i and Cu-related defects have been excluded from the possibility of the origin of green light emission step by step. Finally, it can be concluded that V-Zn is responsible to the observed green light emission, which has good agreement with the theoretical results from first principle calculation.
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  • Resultat 1-3 av 3

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