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Characterization of...
Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial
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- Kasner, Scott E. (författare)
- University of Pennsylvania
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- Lavados, Pablo (författare)
- University of Chile
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- Sharma, Mukul (författare)
- McMaster University
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- Wang, Yongjun (författare)
- Capital University of Medical Sciences
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- Wang, Yilong (författare)
- Capital University of Medical Sciences
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- Dávalos, Antoni (författare)
- Hospital Universitari Germans Trias i Pujol
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- Shamalov, Nikolay (författare)
- Pirogov Russian National Research Medical University (RNRMU)
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- Cunha, Luis (författare)
- University Hospital of Coimbra
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- Lindgren, Arne (författare)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Mikulik, Robert (författare)
- St. Anne's University Hospital Brno
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- Arauz, Antonio (författare)
- Instituto Nacional de Neurología y Neurocirugía
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Lang, Wilfried (författare)
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- Czlonkowska, Anna (författare)
- Medical University of Warsaw
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- Eckstein, Jens (författare)
- University Hospital Basel
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Gagliardi, Rubens (författare)
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- Amarenco, Pierre (författare)
- Hopital Bichat-Claude-Bernard AP-HP
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Ameriso, Sebastián F. (författare)
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- Tatlisumak, Turgut (författare)
- Helsinki University Central Hospital
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- Veltkamp, Roland (författare)
- Imperial College London
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- Hankey, Graeme J. (författare)
- University of Western Australia, Crawley
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- Toni, Danilo S. (författare)
- Sapienza University of Rome
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- Bereczki, Daniel (författare)
- Semmelweis University
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- Uchiyama, Shinichiro (författare)
- Sanno Hospital
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Ntaios, George (författare)
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- Yoon, Byung Woo (författare)
- Seoul National University Hospital
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Brouns, Raf (författare)
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- DeVries Basson, M. M. (författare)
- Tiervlei Trial Centre
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- Endres, Matthias (författare)
- Charité - University Medicine Berlin
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- Muir, Keith (författare)
- University of Glasgow
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Bornstein, Natan (författare)
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Ozturk, Serefnur (författare)
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- O'Donnell, Martin (författare)
- National University of Ireland Galway
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- Mundl, Hardi (författare)
- Bayer Pharma AG
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Pater, Calin (författare)
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Weitz, Jeffrey (författare)
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- Peacock, W. Frank (författare)
- Baylor College of Medicine
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- Swaminathan, Balakumar (författare)
- Population Health Research Institute, Ontario
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- Kirsch, Bodo (författare)
- Bayer Pharma AG
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- Berkowitz, Scott D. (författare)
- Bayer Corporation, USA
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- Peters, Gary (författare)
- Janssen Pharmaceuticals, US
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Pare, Guillaume (författare)
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- Themeles, Ellison (författare)
- University of Pennsylvania
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Shoamanesh, Ashkan (författare)
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Connolly, Stuart J. (författare)
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- Hart, Robert G. (författare)
- University of Pennsylvania
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Journal of Stroke and Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 27:6, s. 1673-1682
- Relaterad länk:
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http://dx.doi.org/10...
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https://helda.helsin...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing rivaroxaban versus aspirin in patients with recent ESUS. Aims: We aimed to describe the baseline characteristics of this large ESUS cohort to explore relationships among key subgroups. Methods: We enrolled 7213 patients at 459 sites in 31 countries. Prespecified subgroups for primary safety and efficacy analyses included age, sex, race, global region, stroke or transient ischemic attack prior to qualifying event, time to randomization, hypertension, and diabetes mellitus. Results: Mean age was 66.9 ± 9.8 years; 24% were under 60 years. Older patients had more hypertension, coronary disease, and cancer. Strokes in older subjects were more frequently cortical and accompanied by radiographic evidence of prior infarction. Women comprised 38% of participants and were older than men. Patients from East Asia were oldest whereas those from Latin America were youngest. Patients in the Americas more frequently were on aspirin prior to the qualifying stroke. Acute cortical infarction was more common in the United States, Canada, and Western Europe, whereas prior radiographic infarctions were most common in East Asia. Approximately forty-five percent of subjects were enrolled within 30 days of the qualifying stroke, with earliest enrollments in Asia and Eastern Europe. Conclusions: NAVIGATE-ESUS is the largest randomized trial comparing antithrombotic strategies for secondary stroke prevention in patients with ESUS. The study population encompasses a broad array of patients across multiple continents and these subgroups provide ample opportunities for future research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Aspirin
- Cerebral embolism
- Cryptogenic stroke
- Embolic Stroke of Undetermined Source (ESUS)
- Randomized trial
- Rivaroxaban
- Stroke
- Stroke prevention
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kasner, Scott E.
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Lavados, Pablo
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Sharma, Mukul
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Wang, Yongjun
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Wang, Yilong
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Dávalos, Antoni
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Shamalov, Nikola ...
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Cunha, Luis
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Lindgren, Arne
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Mikulik, Robert
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Arauz, Antonio
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Lang, Wilfried
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Czlonkowska, Ann ...
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Eckstein, Jens
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Gagliardi, Ruben ...
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Amarenco, Pierre
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Ameriso, Sebasti ...
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Tatlisumak, Turg ...
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Veltkamp, Roland
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Hankey, Graeme J ...
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Toni, Danilo S.
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Bereczki, Daniel
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Uchiyama, Shinic ...
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Ntaios, George
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Yoon, Byung Woo
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Brouns, Raf
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DeVries Basson, ...
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Endres, Matthias
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Muir, Keith
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Bornstein, Natan
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Ozturk, Serefnur
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O'Donnell, Marti ...
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Mundl, Hardi
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Pater, Calin
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Weitz, Jeffrey
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Peacock, W. Fran ...
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Swaminathan, Bal ...
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Kirsch, Bodo
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Berkowitz, Scott ...
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Peters, Gary
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Pare, Guillaume
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Themeles, Elliso ...
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Shoamanesh, Ashk ...
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Connolly, Stuart ...
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Hart, Robert G.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Neurologi
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Journal of Strok ...
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