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Enhancer hijacking ...
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
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Northcott, Paul A (author)
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Lee, Catherine (author)
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Zichner, Thomas (author)
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show more...
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Stütz, Adrian M (author)
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Erkek, Serap (author)
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Kawauchi, Daisuke (author)
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Shih, David J H (author)
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Hovestadt, Volker (author)
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Zapatka, Marc (author)
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Sturm, Dominik (author)
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Jones, David T W (author)
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Kool, Marcel (author)
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Remke, Marc (author)
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Cavalli, Florence M G (author)
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Zuyderduyn, Scott (author)
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Bader, Gary D (author)
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VandenBerg, Scott (author)
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Esparza, Lourdes Adriana (author)
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Ryzhova, Marina (author)
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Wang, Wei (author)
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Wittmann, Andrea (author)
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Stark, Sebastian (author)
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Sieber, Laura (author)
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Seker-Cin, Huriye (author)
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Linke, Linda (author)
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Kratochwil, Fabian (author)
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Jäger, Natalie (author)
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Buchhalter, Ivo (author)
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Imbusch, Charles D (author)
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Zipprich, Gideon (author)
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Raeder, Benjamin (author)
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Schmidt, Sabine (author)
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Diessl, Nicolle (author)
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Wolf, Stephan (author)
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Wiemann, Stefan (author)
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Brors, Benedikt (author)
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Lawerenz, Chris (author)
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Eils, Jürgen (author)
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Warnatz, Hans-Jörg (author)
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Risch, Thomas (author)
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Yaspo, Marie-Laure (author)
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Weber, Ursula D (author)
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Bartholomae, Cynthia C (author)
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von Kalle, Christof (author)
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Turányi, Eszter (author)
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Hauser, Peter (author)
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- Sandén, Emma (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Darabi, Anna (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Siesjö, Peter (author)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Sterba, Jaroslav (author)
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Zitterbart, Karel (author)
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Sumerauer, David (author)
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van Sluis, Peter (author)
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Versteeg, Rogier (author)
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Volckmann, Richard (author)
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Koster, Jan (author)
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Schuhmann, Martin U (author)
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Ebinger, Martin (author)
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Grimes, H Leighton (author)
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Robinson, Giles W (author)
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Gajjar, Amar (author)
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Mynarek, Martin (author)
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von Hoff, Katja (author)
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Rutkowski, Stefan (author)
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Pietsch, Torsten (author)
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Scheurlen, Wolfram (author)
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Felsberg, Jörg (author)
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Reifenberger, Guido (author)
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Kulozik, Andreas E (author)
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von Deimling, Andreas (author)
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Witt, Olaf (author)
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Eils, Roland (author)
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Gilbertson, Richard J (author)
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Korshunov, Andrey (author)
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Taylor, Michael D (author)
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Lichter, Peter (author)
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Korbel, Jan O (author)
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Wechsler-Reya, Robert J (author)
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Pfister, Stefan M (author)
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(creator_code:org_t)
- 2014-06-22
- 2014
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 511:7510, s. 428-428
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://pure.mpg.de/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
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Nature
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To the university's database
- By the author/editor
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Northcott, Paul ...
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Lee, Catherine
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Zichner, Thomas
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Stütz, Adrian M
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Erkek, Serap
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Kawauchi, Daisuk ...
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show more...
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Shih, David J H
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Hovestadt, Volke ...
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Zapatka, Marc
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Sturm, Dominik
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Jones, David T W
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Kool, Marcel
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Remke, Marc
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Cavalli, Florenc ...
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Zuyderduyn, Scot ...
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Bader, Gary D
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VandenBerg, Scot ...
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Esparza, Lourdes ...
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Ryzhova, Marina
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Wang, Wei
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Wittmann, Andrea
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Stark, Sebastian
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Sieber, Laura
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Seker-Cin, Huriy ...
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Linke, Linda
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Kratochwil, Fabi ...
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Jäger, Natalie
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Buchhalter, Ivo
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Imbusch, Charles ...
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Zipprich, Gideon
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Raeder, Benjamin
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Schmidt, Sabine
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Diessl, Nicolle
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Wolf, Stephan
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Wiemann, Stefan
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Brors, Benedikt
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Lawerenz, Chris
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Eils, Jürgen
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Warnatz, Hans-Jö ...
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Risch, Thomas
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Yaspo, Marie-Lau ...
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Weber, Ursula D
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Bartholomae, Cyn ...
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von Kalle, Chris ...
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Turányi, Eszter
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Hauser, Peter
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Sandén, Emma
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Darabi, Anna
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Siesjö, Peter
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Sterba, Jaroslav
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Zitterbart, Kare ...
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Sumerauer, David
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van Sluis, Peter
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Versteeg, Rogier
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Volckmann, Richa ...
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Koster, Jan
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Schuhmann, Marti ...
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Ebinger, Martin
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Grimes, H Leight ...
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Robinson, Giles ...
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Gajjar, Amar
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Mynarek, Martin
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von Hoff, Katja
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Rutkowski, Stefa ...
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Pietsch, Torsten
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Scheurlen, Wolfr ...
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Felsberg, Jörg
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Reifenberger, Gu ...
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Kulozik, Andreas ...
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von Deimling, An ...
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Witt, Olaf
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Eils, Roland
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Gilbertson, Rich ...
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Korshunov, Andre ...
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Taylor, Michael ...
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Lichter, Peter
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Korbel, Jan O
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Wechsler-Reya, R ...
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Pfister, Stefan ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature
- By the university
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Lund University