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Circulating metabol...
Circulating metabolites associated with alcohol intake in the european prospective investigation into cancer and nutrition cohort
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- van Roekel, Eline H. (författare)
- Maastricht University
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- Trijsburg, Laura (författare)
- International Agency for Research on Cancer, World Health Organization
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- Assi, Nada (författare)
- International Agency for Research on Cancer, World Health Organization
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visa fler...
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- Carayol, Marion (författare)
- Montpellier Cancer Institute,Paul Valéry University of Montpellier
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- Achaintre, David (författare)
- International Agency for Research on Cancer, World Health Organization
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, World Health Organization
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- Rinaldi, Sabina (författare)
- International Agency for Research on Cancer, World Health Organization
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- Schmidt, Julie A. (författare)
- University of Oxford
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- Stepien, Magdalena (författare)
- International Agency for Research on Cancer, World Health Organization
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Iqbal, Khalid (författare)
- German Institute of Human Nutrition
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Krogh, Vittorio (författare)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Ricceri, Fulvio (författare)
- University of Turin,Azienda Sanitaria Locale Torino 3
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Peeters, Petra H. (författare)
- University Medical Center Utrecht
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- Bueno-de-Mesquita, Bas (författare)
- National Institute for Public Health and the Environment (RIVM),Imperial College London,University of Malaya,University Medical Center Utrecht
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Lujan-Barroso, Leila (författare)
- Catalan Institute of Oncology
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- Quirós, J. Ramón (författare)
- Public Health Directorate
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- Huerta, José M. (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Molina-Portillo, Elena (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro, Miren (författare)
- Biodonostia Health Research Institute
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- Tsilidis, Konstantinos K. (författare)
- University of Ioannina,Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Rostgaard-Hansen, Agnetha Linn (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University,Aalborg University Hospital
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø
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- Boutron-Ruault, Marie Christine (författare)
- University of Paris-Saclay,Institut Gustave Roussy
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- Severi, Gianluca (författare)
- University of Melbourne,University of Paris-Saclay,Institut Gustave Roussy
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Karakatsani, Anna (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Kotanidou, Anastasia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Håkansson, Anders (författare)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups
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- Malm, Johan (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Weijenberg, Matty P. (författare)
- Maastricht University
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Travis, Ruth C. (författare)
- University of Oxford
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2018-05-22
- 2018
- Engelska.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 10:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTMp180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption withmetabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Acylcarnitines
- Alcohol
- Amino acids
- Lipid metabolites
- Targeted metabolomics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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van Roekel, Elin ...
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Trijsburg, Laura
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Assi, Nada
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Carayol, Marion
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Achaintre, David
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Murphy, Neil
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visa fler...
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Rinaldi, Sabina
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Schmidt, Julie A ...
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Stepien, Magdale ...
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Kaaks, Rudolf
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Kühn, Tilman
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Boeing, Heiner
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Iqbal, Khalid
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Ricceri, Fulvio
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Panico, Salvator ...
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Peeters, Petra H ...
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Bueno-de-Mesquit ...
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Ardanaz, Eva
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Lujan-Barroso, L ...
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Quirós, J. Ramón
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Huerta, José M.
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Molina-Portillo, ...
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Dorronsoro, Mire ...
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Tsilidis, Konsta ...
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Riboli, Elio
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Rostgaard-Hansen ...
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Tjønneland, Anne
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Overvad, Kim
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Weiderpass, Elis ...
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Boutron-Ruault, ...
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Severi, Gianluca
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Kotanidou, Anast ...
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Håkansson, Ander ...
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Malm, Johan
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Weijenberg, Matt ...
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Gunter, Marc J.
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Jenab, Mazda
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Johansson, Matti ...
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Travis, Ruth C.
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Scalbert, August ...
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Ferrari, Pietro
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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Nutrients
- Av lärosätet
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Lunds universitet
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Karolinska Institutet