| 1. |
- Schael, S, et al.
(author)
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Precision electroweak measurements on the Z resonance
- 2006
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In: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Research review (peer-reviewed)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
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| 3. |
- Zong, N. C., et al.
(author)
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Integration of cardiac proteome biology and medicine by a specialized knowledgebase
- 2013
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In: Circulation Research. - 0009-7330 .- 1524-4571. ; 113:9, s. 1043-1053
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Journal article (peer-reviewed)abstract
- Rationale: Omics sciences enable a systems-level perspective in characterizing cardiovascular biology. Integration of diverse proteomics data via a computational strategy will catalyze the assembly of contextualized knowledge, foster discoveries through multidisciplinary investigations, and minimize unnecessary redundancy in research efforts. Objective: The goal of this project is to develop a consolidated cardiac proteome knowledgebase with novel bioinformatics pipeline and Web portals, thereby serving as a new resource to advance cardiovascular biology and medicine. Methods and results: We created Cardiac Organellar Protein Atlas Knowledgebase (COPaKB; www.HeartProteome.org), a centralized platform of high-quality cardiac proteomic data, bioinformatics tools, and relevant cardiovascular phenotypes. Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments from human, mouse, drosophila, and Caenorhabditis elegans, as well as expression images of 10 924 proteins in human myocardium. In addition, the Java-coded bioinformatics tools provided by COPaKB enable cardiovascular investigators in all disciplines to retrieve and analyze pertinent organellar protein properties of interest. Conclusions: COPaKB provides an innovative and interactive resource that connects research interests with the new biological discoveries in protein sciences. With an array of intuitive tools in this unified Web server, nonproteomics investigators can conveniently collaborate with proteomics specialists to dissect the molecular signatures of cardiovascular phenotypes.
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| 4. |
- Orsborne, Sarah R.E., et al.
(author)
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Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks
- 2023
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In: Journal of the American Chemical Society. - : American Chemical Society. - 0002-7863 .- 1520-5126. ; 145:9, s. 5431-5438
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Journal article (peer-reviewed)abstract
- Singlet fission (SF), an exciton-doubling process observed in certain molecular semiconductors where two triplet excitons are generated from one singlet exciton, requires correctly tuned intermolecular coupling to allow separation of the two triplets to different molecular units. We explore this using DNA-encoded assembly of SF-capable pentacenes into discrete π-stacked constructs of defined size and geometry. Precise structural control is achieved via a combination of the DNA duplex formation between complementary single-stranded DNA and the local molecular geometry that directs the SF chromophores into a stable and predictable slip-stacked configuration, as confirmed by molecular dynamics (MD) modeling. Transient electron spin resonance spectroscopy revealed that within these DNA-assembled pentacene stacks, SF evolves via a bound triplet pair quintet state, which subsequently converts into free triplets. SF evolution via a long-lived quintet state sets specific requirements on intermolecular coupling, rendering the quintet spectrum and its zero-field-splitting parameters highly sensitive to intermolecular geometry. We have found that the experimental spectra and zero-field-splitting parameters are consistent with a slight systematic strain relative to the MD-optimized geometry. Thus, the transient electron spin resonance analysis is a powerful tool to test and refine the MD-derived structure models. DNA-encoded assembly of coupled semiconductor molecules allows controlled construction of electronically functional structures, but brings with it significant dynamic and polar disorders. Our findings here of efficient SF through quintet states demonstrate that these conditions still allow efficient and controlled semiconductor operation and point toward future opportunities for constructing functional optoelectronic systems.
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| 5. |
- Wein, Nicolas, et al.
(author)
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Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice
- 2014
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 20:9, s. 992-1000
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Journal article (peer-reviewed)abstract
- Most mutations that truncate the reading frame of the DMD gene cause loss of dystrophin expression and lead to Duchenne muscular dystrophy. However, amelioration of disease severity has been shown to result from alternative, translation initiation beginning in DMD exon 6 that leads to expression of a highly functional N-truncated dystrophin. Here we demonstrate that this isoform results from usage of an internal ribosome entry site (IRES) within exon 5 that is glucocorticoid inducible. We confirmed IRES activity by both peptide sequencing and ribosome profiling in muscle from individuals with minimal symptoms despite the presence of truncating mutations. We generated a truncated reading frame upstream of the IRES by exon skipping, which led to synthesis of a functional N-truncated isoform in both human subject derived cell lines and in a new DMD mouse model, where expression of the truncated isoform protected muscle from contraction-induced injury and corrected muscle force to the same level as that observed in control mice. These results support a potential therapeutic approach for patients with mutations within the 5' exons of DMD.
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| 6. |
- Alur, R., et al.
(author)
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Modeling and analysis of multi-hop control networks : RTAS 2009, Proceedings
- 2009
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In: 15TH IEEE REAL-TIME AND EMBEDDED TECHNOLOGY AND APPLICATION SYMPOSIUM. - : IEEE Computer Society. - 9780769536361 ; , s. 223-232
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Conference paper (peer-reviewed)abstract
- We propose a mathematical framework, inspired by the WirelessHART specification, for modeling and analysing multi-hop communication networks. The framework is designed for systems consisting of multiple control loops closed over a multi-hop communication network. We separate control, topology, routing, and scheduling and propose formal syntax and semantics for the dynamics of the composed system. The main technical contribution of the paper is an explicit translation of multi-hop control networks to switched systems. We describe a Mathematica notebook that automates the translation of multihop control networks to switched systems, and use this tool to show how techniques for analysis of switched systems can be used to address control and networking co-design challenges.
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| 7. |
- D'Innocenzo, A., et al.
(author)
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Scalable scheduling algorithms for wireless networked control systems
- 2009
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In: 2009 IEEE INTERNATIONAL CONFERENCE ON AUTOMATION SCIENCE AND ENGINEERING. - : IEEE. - 9781424445783 ; , s. 409-414
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Conference paper (peer-reviewed)abstract
- In this paper, we address the problem of designing scalable scheduling and routing policies over a time-triggered multi-hop control network, when closing a considerable number of control loops on the same network. The key idea is to formally define by means of regular languages the set of schedules for each control loop that satisfy a given control specification, and to exploit operators on regular languages to compute the set of schedules for the whole system. In order to test our methodology, we address a mineral floatation control problem derived from the Boliden (a swedish mining company) mine in Garpenberg, and propose a scheduling solution that can be implemented on systems compliant with communication protocols for wireless networks (e.g. the WirelessHART specification).
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| 8. |
- Vogl, Gregory, et al.
(author)
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Identification of machine tool geometric performance using on-machine inertial measurements
- 2017
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In: 6th International Conference on Virtual Machining Process Technology (VMPT 2017).
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Conference paper (peer-reviewed)abstract
- Machine tools degrade during operations, yet accurately detecting degradation of machine components such as linear axes is typically a manual and time-consuming process. Thus, manufacturers need automated and efficient methods to diagnose the condition of their machine tool linear axes with minimal disruptions to production. Towards this goal, a method was developed to use accelerometer and rate gyroscope data from an inertial measurement unit (IMU) for identification of changes in the translational and angular errors due to axis degradation. An IMU was created for application of the method on a machine tool. As a proof of concept for detection of translational error motions, IMU data was collected on a machine tool with experimentally simulated degradation; as the worktable moved along its nominal path, a cross-axis moved along a swept sinusoidal pattern with micrometer-level amplitudes. In another experiment, data was collected at three different locations on a worktable for the same axis motion. These experiments showed that the IMU detected micrometer-level and microradian-level degradation of linear axes, revealing that the IMU-based method is plausible for use in smart machine tools.
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| 9. |
- Willschütz, H. G., et al.
(author)
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Recursively coupled thermal and mechanical FEM-analysis of lower plenum creep failure experiments
- 2006
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In: Annals of Nuclear Energy. - : Elsevier BV. - 0306-4549 .- 1873-2100. ; 33:2, s. 126-148
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Journal article (peer-reviewed)abstract
- Postulating an unlikely core melt down accident for a light water reactor (LWR), the possible failure mode of the reactor pressure vessel (RPV) and its failure time have to be investigated for a determination of the load conditions for subsequent containment analyses. Worldwide several experiments have been performed in this field accompanied with material properties evaluation, theoretical, and numerical work. At the Institute of Safety Research of the FZR a finite element model (FEM) has been developed simulating the thermal processes and the viscoplastic behaviour of the vessel wall. An advanced model for creep and material damage has been established and has been validated using experimental data. The thermal and the mechanical calculations are sequentially and recursively coupled. The model is capable of evaluating fracture time and fracture position of a vessel with an internally heated melt pool. The model was applied to pre- and post-test calculations for the FOREVER test series representing the lower head RPV of a pressurised water reactor (PWR) in the geometrical scale of 1:10. These experiments were performed at the Royal Institute of Technology in Stockholm. In this paper the differences between the results of a simple coupled and a recursive coupled FE-simulation are highlighted. Due to the thermal expansion at the beginning and the accumulating creep strain later on the shape of the melt pool and of the vessel wall are changing. Despite of the fact that these relative small geometrical changes take place relatively slowly over time, the effect on the temperature field is rather significant concerning the mechanical material behaviour and the resulting failure time. Assuming the same loading conditions, the change in the predicted failure time between the simple and the recursive coupled model is in the order of magnitude of the total failure time of the simple model. The comparison with results from the FOREVER-experiments shows that the recursive coupled model is closer to reality than the one-way coupled model.
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