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1.
  • Folkersen, Lasse, et al. (författare)
  • Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
  • 2020
  • Ingår i: Nature metabolism. - : Springer Nature. - 2522-5812. ; 2:10, s. 1135-1148
  • Tidskriftsartikel (refereegranskat)abstract
    • Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.
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2.
  • Marais, Andrew, et al. (författare)
  • New insights into the mechanisms behind the strengthening of lignocellulosic fibrous networks with polyamines
  • 2014
  • Ingår i: Cellulose (London). - : Springer Verlag (Germany). - 0969-0239 .- 1572-882X. ; 21:6, s. 3941-3950
  • Tidskriftsartikel (refereegranskat)abstract
    • Polyelectrolytes have been used extensively in the papermaking industry for various purposes. Although recent studies have shown that polyamines can be efficient dry-strength additives, the mechanism governing the strength enhancement of paper materials following the adsorption of polyamines onto pulp fibres is still not well understood. In this study, the effect of the adsorption of polyallylamine hydrochloride (PAH) onto the surface of unbleached kraft pulp fibres was investigated on both the fibre and the network scale. Isolated fibre crosses were mechanically tested to evaluate the impact of the chemical additive on the interfibre joint strength on the microscopic scale and the effect was compared with that previously observed on the paper sheet scale. X-ray microtomography was used to understand structural changes in the fibrous network following the adsorption of a polyamine such as PAH. Using image analysis methods, it was possible to determine the number of interfibre contacts (or joints) per unit length of fibre as well as the average interfibre joint contact area. The results showed that the median interfibre joint strength increased by 18 % upon adsorption of PAH. This can be achieved both by a larger molecular contact area in the contact zones and by a stronger molecular adhesion. The addition of the polymer also increased the number of efficient interfibre contacts per sheet volume. This combination of effects is the reason why polyamines such as PAH can increase the dry tensile strength of paper materials.
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3.
  • Egard, Mikael, et al. (författare)
  • Frequency Modulation in mm-Wave InGaAs MOSFET/RTD Wavelet Generators
  • 2013
  • Ingår i: 2013 International Conference on Indium Phosphide and Related Materials (IPRM). - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 1092-8669. ; , s. 1-2
  • Konferensbidrag (refereegranskat)abstract
    • Co-integration of an InGaAs MOSFET and an RTD is performed to realize a wavelet generator. The large transconductance of the MOSFET (1.9 mS/mu m) is used to switch the current in an oscillator circuit and coherent wavelets down to 41 ps are generated in the frequency domain of 50 to 100 GHz. The lowest power consumption measured is 1.9 pJ/pulse. It is found that the supply bias can be used to modulate the center frequency of the wavelets.
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4.
  • Egard, Mikael, et al. (författare)
  • High-Frequency Performance of Self-Aligned Gate-Last Surface Channel In0.53Ga0.47As MOSFET
  • 2012
  • Ingår i: IEEE Electron Device Letters. - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 0741-3106. ; 33:3, s. 369-371
  • Tidskriftsartikel (refereegranskat)abstract
    • We have developed a self-aligned L-g = 55 nm In-0.53 Ga-0.47 As MOSFET incorporating metal-organic chemical vapor deposition regrown n(++) In0.6Ga0.4As source and drain regions, which enables a record low on-resistance of 199 Omega mu m. The regrowth process includes an InP support layer, which is later removed selectively to the n(++) contact layer. This process forms a high-frequency compatible device using a low-complexity fabrication scheme. We report on high-frequency measurements showing f(max) of 292 GHz and f(t) of 244 GHz. These results are accompanied by modeling of the device, which accounts for the frequency response of gate oxide border traps and impact ionization phenomenon found in narrow band gap FETs. The device also shows a high drive current of 2.0 mA/mu m and a high extrinsic transconductance of 1.9 mS/mu m. These excellent properties are attributed to the use of a gate-last process, which does not include high temperature or dry-etch processes.
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5.
  • Egard, Mikael, et al. (författare)
  • High Transconductance Self-Aligned Gate-Last Surface Channel In0.53Ga0.47As MOSFET
  • 2011
  • Ingår i: 2011 IEEE International Electron Devices Meeting (IEDM). - : IEEE - Institute of Electrical and Electronics Engineers Inc..
  • Konferensbidrag (refereegranskat)abstract
    • In this paper we present a 55 nm gate length In0.53Ga0.47As MOSFET with extrinsic transconductance of 1.9 mS/mu m and on-resistance of 199 Omega mu m. T he self-aligned MOSFET is formed using metalorganic chemical vapor deposition regrowth of highly doped source and drain access regions. The fabricated 140 nm gate length devices shows a low subthreshold swing of 79 mV/decade, which is attributed to the described low temperature gate-last process scheme.
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6.
  • Egard, Mikael, et al. (författare)
  • In0.53Ga0.47As RTD-MOSFET Millimeter-Wave Wavelet Generator
  • 2012
  • Ingår i: IEEE Electron Device Letters. - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 0741-3106. ; 33:7, s. 970-972
  • Tidskriftsartikel (refereegranskat)abstract
    • We report on the fabrication of a self-aligned regrown In0.53Ga0.47As metal-oxide-semiconductor field-effect transistor (MOSFET) and a resonant tunneling diode (RTD). The performance of these devices is demonstrated by integrating them in parallel with an inductive coplanar waveguide stub to form a highly energy-efficient 70-GHz wavelet generator. The fast switching and low on-resistance of the MOSFET make it possible to kick-start and rapidly quench this RTD-driven oscillator circuit, which produces 41-ps-short wavelets at 15 Gpulses/s, a peak output power of 7 dBm, and an energy consumption of 1.9 pJ/pulse.
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7.
  • Egard, Mikael, et al. (författare)
  • Self-aligned gate-last surface channel In0.53Ga0.47As MOSFET with selectively regrown source and drain contact layers
  • 2011
  • Ingår i: 69th Device Research Conference, DRC 2011 - Conference Digest. - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 9781612842417
  • Konferensbidrag (refereegranskat)abstract
    • III-V MOSFETs are currently being considered as a candidate for future high performance transistors [1]. In particular, In1-xGaxAs compounds are investigated for application in digital logic due to their advantageous electronic properties [2]. III-V technologies may be introduced beyond the 22 nm node, which will require a self aligned III/V device architecture as well as integration of high-¿ gate oxides.
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8.
  • Fröberg, Linus, et al. (författare)
  • Heterostructure Barriers in Wrap Gated Nanowire FETs
  • 2008
  • Ingår i: IEEE Electron Device Letters. - : IEEE - Institute of Electrical and Electronics Engineers Inc.. - 0741-3106. ; 29:9, s. 981-983
  • Tidskriftsartikel (refereegranskat)
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9.
  • Fröberg, Linus, et al. (författare)
  • Vertical InAs nanowire wrap-gate FETs
  • 2006
  • Ingår i: Book of abstracts: Semicond Nanowires Symp, Eindhoven, The Netherlands (2006).
  • Konferensbidrag (refereegranskat)
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10.
  • Krishnaraja, Abinaya, et al. (författare)
  • Tuning of Source Material for InAs/InGaAsSb/GaSb Application-Specific Vertical Nanowire Tunnel FETs
  • 2020
  • Ingår i: ACS Applied Electronic Materials. - : The American Chemical Society (ACS). - 2637-6113. ; 2:9, s. 2882-2887
  • Tidskriftsartikel (refereegranskat)abstract
    • Tunnel field-effect transistors (TFETs) are promising candidates that have demonstrated potential for and beyond the 3 nm technology node. One major challenge for the TFETs is to optimize the heterojunction for high drive currents while achieving steep switching. Thus far, such optimization has mainly been addressed theoretically. Here, we experimentally investigate the influence of the source segment composition on the performance for vertical nanowire InAs/InGaAsSb/GaSb TFETs. Compositional analysis using transmission electron microscopy is combined with simulations to interpret the results from electrical characterization data. The results show that subthreshold swing (S) and transconductance (gm) decrease with increasing arsenic composition until the strain due to lattice mismatch increases them both. The role of indium concentration at the junction is also examined. This systematic optimization has rendered sub-40 mV/dec operating TFETs with a record transconductance efficiency gm/ID = 100 V-1, and it shows that different source materials are preferred for various applications.
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