SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Willerslev Eske) "

Sökning: WFRF:(Willerslev Eske)

  • Resultat 1-10 av 65
  • [1]234567Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Allentoft, M. E., et al. (författare)
  • Population genomics of Bronze Age Eurasia
  • 2015
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 522:7555, s. 167-
  • Tidskriftsartikel (refereegranskat)abstract
    • The Bronze Age of Eurasia (around 3000-1000 BC) was a period of major cultural changes. However, there is debate about whether these changes resulted from the circulation of ideas or from human migrations, potentially also facilitating the spread of languages and certain phenotypic traits. We investigated this by using new, improved methods to sequence low-coverage genomes from 101 ancient humans from across Eurasia. We show that the Bronze Age was a highly dynamic period involving large-scale population migrations and replacements, responsible for shaping major parts of present-day demographic structure in both Europe and Asia. Our findings are consistent with the hypothesized spread of Indo-European languages during the Early Bronze Age. We also demonstrate that light skin pigmentation in Europeans was already present at high frequency in the Bronze Age, but not lactose tolerance, indicating a more recent onset of positive selection on lactose tolerance than previously thought.
  •  
2.
  • Karmin, Monika, et al. (författare)
  • A recent bottleneck of Y chromosome diversity coincides with a global change in culture.
  • 2015
  • Ingår i: Genome Research. - 1088-9051 .- 1549-5469. ; 25:4
  • Tidskriftsartikel (refereegranskat)abstract
    • It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
  •  
3.
  • Lorenzen, Eline D., et al. (författare)
  • Species-specific responses of Late Quaternary megafauna to climate and humans
  • 2011
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 479:7373, s. 359-364
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA, species distribution models and the human fossil record to elucidate how climate and humans shaped the demographic history of woolly rhinoceros, woolly mammoth, wild horse, reindeer, bison and musk ox. We show that climate has been a major driver of population change over the past 50,000 years. However, each species responds differently to the effects of climatic shifts, habitat redistribution and human encroachment. Although climate change alone can explain the extinction of some species, such as Eurasian musk ox and woolly rhinoceros, a combination of climatic and anthropogenic effects appears to be responsible for the extinction of others, including Eurasian steppe bison and wild horse. We find no genetic signature or any distinctive range dynamics distinguishing extinct from surviving species, emphasizing the challenges associated with predicting future responses of extant mammals to climate and human-mediated habitat change.
  •  
4.
  • Muhlemann, B., et al. (författare)
  • Ancient hepatitis B viruses from the Bronze Age to the Medieval period
  • 2018
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 557:7705, s. 418-423
  • Tidskriftsartikel (refereegranskat)abstract
    • Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to between 8.6 and 20.9 thousand years ago, and we estimate a substitution rate of 8.04 x 10(-6-)1.51 x 10(-5) nucleotide substitutions per site per year. In several cases, the geographical locations of the ancient genotypes do not match present-day distributions. Genotypes that today are typical of Africa and Asia, and a subgenotype from India, are shown to have an early Eurasian presence. The geographical and temporal patterns that we observe in ancient and modern HBV genotypes are compatible with well-documented human migrations during the Bronze and Iron Ages(1,2). We provide evidence for the creation of HBV genotype A via recombination, and for a long-term association of modern HBV genotypes with humans, including the discovery of a human genotype that is now extinct. These data expose a complexity of HBV evolution that is not evident when considering modern sequences alone.
  •  
5.
  • Muhlemann, B., et al. (författare)
  • Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans
  • 2018
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 115:29, s. 7557-7562
  • Tidskriftsartikel (refereegranskat)abstract
    • Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.
  •  
6.
  • Skoglund, Pontus, et al. (författare)
  • Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers
  • 2014
  • Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 344:6185, s. 747-750
  • Tidskriftsartikel (refereegranskat)abstract
    • Prehistoric population structure associated with the transition to an agricultural lifestyle in Europe remains a contentious idea. Population-genomic data from 11 Scandinavian Stone Age human remains suggest that hunter-gatherers had lower genetic diversity than that of farmers. Despite their close geographical proximity, the genetic differentiation between the two Stone Age groups was greater than that observed among extant European populations. Additionally, the Scandinavian Neolithic farmers exhibited a greater degree of hunter-gatherer–related admixture than that of the Tyrolean Iceman, who also originated from a farming context. In contrast, Scandinavian hunter-gatherers displayed no significant evidence of introgression from farmers. Our findings suggest that Stone Age foraging groups were historically in low numbers, likely owing to oscillating living conditions or restricted carrying capacity, and that they were partially incorporated into expanding farming groups.
  •  
7.
  • Skoglund, Pontus, et al. (författare)
  • Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe
  • 2012
  • Ingår i: Science. - 0036-8075 .- 1095-9203. ; 336:6080, s. 466-469
  • Tidskriftsartikel (refereegranskat)abstract
    • The farming way of life originated in the Near East some 11,000 years ago and had reached most of the European continent 5000 years later. However, the impact of the agricultural revolution on demography and patterns of genomic variation in Europe remains unknown. We obtained 249 million base pairs of genomic DNA from similar to 5000-year-old remains of three hunter-gatherers and one farmer excavated in Scandinavia and find that the farmer is genetically most similar to extant southern Europeans, contrasting sharply to the hunter-gatherers, whose distinct genetic signature is most similar to that of extant northern Europeans. Our results suggest that migration from southern Europe catalyzed the spread of agriculture and that admixture in the wake of this expansion eventually shaped the genomic landscape of modern-day Europe.
  •  
8.
  • Anderung, Cecilia, 1972- (författare)
  • Genetic Analyses of Bovid Remains and the Origin of Early European Cattle
  • 2006
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • The aurochs Bos primigenius, extinct since 1627, was the wild progenitor of cattle. It is believed that all European cattle originate from one domestication event in the Near East 10 000 years ago. However, it is evident from the archaeological record that the aurochs survived into historic time and spent many years existing alongside domestic cattle. Thus, a question posed is whether aurochsen were locally domesticated or incorporated into early domestic cattle stock.In this thesis, genetic techniques are applied to ancient and modern DNA from bovids in order to study questions relating to the origin of early European cattle. DNA from ancient specimens is fragmented and in greatly reduced quantity. Therefore mitochondrial DNA, present in many copies in the living cell, has long been dominating the ancient DNA research field. Analyses of ancient DNA presented in this work are based on both mitochondrial DNA and nuclear DNA, through the study of Single Nuclear Polymorohism (SNPs). A method for typing ancient SNPs was developed and applied to ancient cattle bones.Mitochondrial DNA of cattle is structured into five geographically distributed lineages, the dominant lineage in Europe is also found in the Near East where additional lineages are found. This pattern has been attributed to the proposed domestication event in the Near East from where cattle carrying the single lineage were brought to Europe. However, the results presented here show that cattle domestication was more complicated than previously suggested. SNP data from extant cattle and bones from cattle and aurochs point towards a hybridisation event. European cattle appear indeed to have been domesticated in the Near East and brought in to the European continent from there. However, once in Europe, hybridisation with local aurochsen took place. It appears therefore that today’s cattle descend both from both Anatolian and European aurochsen.
  •  
9.
  • Axelsson, Erik, et al. (författare)
  • The effect of ancient DNA damage on inferences of demographic histories.
  • 2008
  • Ingår i: Molecular biology and evolution. - 0737-4038 .- 1537-1719. ; 25:10, s. 2181-7
  • Tidskriftsartikel (refereegranskat)abstract
    • The field of ancient DNA (aDNA) is casting new light on many evolutionary questions. However, problems associated with the postmortem instability of DNA may complicate the interpretation of aDNA data. For example, in population genetic studies, the inclusion of damaged DNA may inflate estimates of diversity. In this paper, we examine the effect of DNA damage on population genetic estimates of ancestral population size. We simulate data using standard coalescent simulations that include postmortem damage and show that estimates of effective population sizes are inflated around, or right after, the sampling time of the ancestral DNA sequences. This bias leads to estimates of increasing, and then decreasing, population sizes, as observed in several recently published studies. We reanalyze a recently published data set of DNA sequences from the Bison (Bison bison/Bison priscus) and show that the signal for a change in effective population size in this data set vanishes once the effects of putative damage are removed. Our results suggest that population genetic analyses of aDNA sequences, which do not accurately account for damage, should be interpreted with great caution.
  •  
10.
  • Bærholm Schnell, Ida, et al. (författare)
  • Characterisation of insect and plant origins using DNA extracted from small volumes of bee honey
  • 2010
  • Ingår i: Arthropod-Plant Interactions. - Dordrecht : Springer Science+Business Media B.V.. - 1872-8855 .- 1872-8847. ; 4:2, s. 107-116
  • Tidskriftsartikel (refereegranskat)abstract
    • A DNA-based tool was validated that potentially enables the characterisation of both plant and insect of origin of small (approximately 1 ml) samples of bee honey. Using this method, mitochondrial, nuclear and chloroplast DNA (mtDNA, nuDNA, cpDNA) markers were successfully extracted, PCR amplified, and sequenced from a range of honeys, and the relative amount of plant nuDNA and cpDNA, and bee mtDNA in the samples was quantified using quantitative real-time PCR. Short, but taxonomically informative lengths of insect and plant organelle DNA could be routinely recovered from all honey samples tested, and longer organelle, and nuclear DNA sequences can be recovered from many. The data also enabled preliminary characterisation of the quality of these different DNA sources in honey. Although the absolute quantity of the different genetic markers varied considerably between sample, a general trend was observed of insect mtDNA dominating over plant organelle DNA, and with plant nuclear DNA at the lowest levels. Furthermore there was a clear correlation between the plant DNA content and the success of the PCR assays. To maximise successful characterisation of samples, future studies are recommended to focus on the use of organelle markers, and limit the size of PCR amplicons targeted, although with appropriate sample selection and assay optimisation, other approaches may be possible.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 65
  • [1]234567Nästa
Typ av publikation
tidskriftsartikel (57)
annan publikation (4)
forskningsöversikt (3)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (59)
övrigt vetenskapligt (4)
populärvet., debatt m.m. (2)
Författare/redaktör
Willerslev, Eske (64)
Gilbert, M. Thomas P ... (38)
Nielsen, Rasmus (20)
Götherström, Anders (20)
Orlando, Ludovic (19)
Dalen, Love (14)
visa fler...
Malmström, Helena (14)
Campos, Paula F (12)
Rasmussen, Morten (11)
Allentoft, Morten E. (11)
Rasmussen, Simon (11)
Shapiro, Beth (11)
Skoglund, Pontus (11)
Sicheritz-Pontén, Th ... (10)
Metspalu, Mait (10)
Jakobsson, Mattias (10)
Holmlund, Gunilla (9)
Storå, Jan (9)
Gotherstrom, Anders (9)
Kristiansen, Kristia ... (8)
Sikora, Martin (8)
Sjögren, Karl-Göran, ... (7)
Hofreiter, Michael (7)
Villems, Richard (7)
Meldgaard, Morten (6)
Metspalu, Ene (6)
Thomas, Mark G. (5)
Willerslev, E. (5)
Margaryan, Ashot (5)
Stenderup, Jesper (5)
Malaspinas, Anna-Sap ... (5)
Petersen, Bent (5)
Zhang, Guojie (5)
Lorenzen, Eline D. (5)
Eriksson, Anders (4)
Axelsson, Erik (4)
Lidén, Kerstin (4)
Lynnerup, Niels (4)
Ho, Simon Y. W. (4)
Moiseyev, Vyacheslav (4)
Vinner, Lasse (4)
Sinding, Mikkel-Holg ... (4)
Haile, James (4)
Hansen, Anders J. (4)
Stora, Jan (4)
Ramos-Madrigal, Jazm ... (4)
Germonpré, Mietje (4)
Harkins, Timothy T (4)
Brandström Durling, ... (4)
Wang, Jun (4)
visa färre...
Lärosäte
Uppsala universitet (45)
Stockholms universitet (12)
Göteborgs universitet (9)
Naturhistoriska riksmuseet (8)
Linköpings universitet (4)
Lunds universitet (4)
visa fler...
Sveriges Lantbruksuniversitet (3)
Umeå universitet (1)
visa färre...
Språk
Engelska (64)
Svenska (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (43)
Humaniora (14)
Medicin och hälsovetenskap (4)
Lantbruksvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy