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Sökning: WFRF:(Wilson James F) > Lunds universitet

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Numrering	Referens	Omslagsbild	Hitta
1.	Jakobsson, J., et al. (författare) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Tidskriftsartikel (refereegranskat)
2.	Ahmad, T, et al. (författare) In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study 2017 Ingår i: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 43:12, s. 2324-2332 Tidskriftsartikel (refereegranskat)
3.	James, SL, et al. (författare) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 Ingår i: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1789-1858 Tidskriftsartikel (refereegranskat)
4.	Kyu, HH, et al. (författare) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 Ingår i: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1859-1922 Tidskriftsartikel (refereegranskat)
5.	2019 Tidskriftsartikel (refereegranskat)
6.	Halliday, A, et al. (författare) Status update and interim results from the asymptomatic carotid surgery trial-2 (ACST-2) 2013 Ingår i: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. - : Elsevier BV. - 1532-2165. ; 46:5, s. 510-518 Tidskriftsartikel (refereegranskat)
7.	Roth, GA, et al. (författare) Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 Ingår i: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1736-1788 Tidskriftsartikel (refereegranskat)
8.	Kanoni, Stavroula, et al. (författare) Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. 2022 Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1 Tidskriftsartikel (refereegranskat)abstract Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
9.	Locke, Adam E, et al. (författare) Genetic studies of body mass index yield new insights for obesity biology. 2015 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Tidskriftsartikel (refereegranskat)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
10.	Scott, Robert A., et al. (författare) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways 2012 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:9, s. 991-1005 Tidskriftsartikel (refereegranskat)abstract Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.

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Resultat 1-10 av 98

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Typ av publikation: tidskriftsartikel (97); annan publikation (1)

Typ av innehåll: refereegranskat (96); övrigt vetenskapligt/konstnärligt (2)

Författare/redaktör: Boehnke, Michael (41); Wareham, Nicholas J. (39); McCarthy, Mark I (38); Loos, Ruth J F (38); Lind, Lars (37); Hayward, Caroline (37); visa fler...; Langenberg, Claudia (36); Mohlke, Karen L (36); Boerwinkle, Eric (35); Groop, Leif (34); Salomaa, Veikko (34); Wilson, James F. (34); Rudan, Igor (33); Laakso, Markku (33); Stefansson, Kari (33); Gudnason, Vilmundur (33); van Duijn, Cornelia ... (32); Tuomilehto, Jaakko (32); Gieger, Christian (32); Lindgren, Cecilia M. (32); Morris, Andrew P. (32); Deloukas, Panos (31); Luan, Jian'an (31); Thorleifsson, Gudmar (30); Uitterlinden, André ... (30); Esko, Tõnu (30); Thorsteinsdottir, Un ... (29); Hofman, Albert (29); Kuusisto, Johanna (28); Harris, Tamara B (28); Psaty, Bruce M (28); Polasek, Ozren (28); Ridker, Paul M. (27); Chasman, Daniel I. (27); Rotter, Jerome I. (27); Collins, Francis S. (27); Campbell, Harry (26); Mahajan, Anubha (26); Metspalu, Andres (26); Wilson, James G. (26); Jackson, Anne U. (26); Melander, Olle (25); Hansen, Torben (25); Ingelsson, Erik (25); Palmer, Colin N. A. (25); Zhang, Weihua (25); Peters, Annette (24); Barroso, Ines (24); Feitosa, Mary F. (24); Chambers, John C. (24); visa färre...

Lärosäte: Lunds universitet (98)Ta bort avgränsningen; Uppsala universitet (66); Karolinska Institutet (55); Umeå universitet (31); Göteborgs universitet (27); Högskolan Dalarna (8); visa fler...; Chalmers tekniska högskola (5); Stockholms universitet (4); Malmö universitet (3); Sveriges Lantbruksuniversitet (3); Kungliga Tekniska Högskolan (2); Linköpings universitet (2); Högskolan i Halmstad (1); Örebro universitet (1); Mittuniversitetet (1); visa färre...

Språk: Engelska (98)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (90); Naturvetenskap (20)

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