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- Yaghootkar, Hanieh, et al.
(författare)
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Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
- 2020
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2806-2818
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Tidskriftsartikel (refereegranskat)abstract
- Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
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| 3. |
- Korablev, O., et al.
(författare)
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The Atmospheric Chemistry Suite (ACS) of Three Spectrometers for the ExoMars 2016 Trace Gas Orbiter
- 2018
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Ingår i: Space Science Reviews. - : Springer. - 0038-6308 .- 1572-9672. ; 214:1
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Tidskriftsartikel (refereegranskat)abstract
- The Atmospheric Chemistry Suite (ACS) package is an element of the Russian contribution to the ESA-Roscosmos ExoMars 2016 Trace Gas Orbiter (TGO) mission. ACS consists of three separate infrared spectrometers, sharing common mechanical, electrical, and thermal interfaces. This ensemble of spectrometers has been designed and developed in response to the Trace Gas Orbiter mission objectives that specifically address the requirement of high sensitivity instruments to enable the unambiguous detection of trace gases of potential geophysical or biological interest. For this reason, ACS embarks a set of instruments achieving simultaneously very high accuracy (ppt level), very high resolving power (>10,000) and large spectral coverage (0.7 to 17 μm—the visible to thermal infrared range). The near-infrared (NIR) channel is a versatile spectrometer covering the 0.7–1.6 μm spectral range with a resolving power of ∼20,000. NIR employs the combination of an echelle grating with an AOTF (Acousto-Optical Tunable Filter) as diffraction order selector. This channel will be mainly operated in solar occultation and nadir, and can also perform limb observations. The scientific goals of NIR are the measurements of water vapor, aerosols, and dayside or night side airglows. The mid-infrared (MIR) channel is a cross-dispersion echelle instrument dedicated to solar occultation measurements in the 2.2–4.4 μm range. MIR achieves a resolving power of >50,000. It has been designed to accomplish the most sensitive measurements ever of the trace gases present in the Martian atmosphere. The thermal-infrared channel (TIRVIM) is a 2-inch double pendulum Fourier-transform spectrometer encompassing the spectral range of 1.7–17 μm with apodized resolution varying from 0.2 to 1.3 cm−1. TIRVIM is primarily dedicated to profiling temperature from the surface up to ∼60 km and to monitor aerosol abundance in nadir. TIRVIM also has a limb and solar occultation capability. The technical concept of the instrument, its accommodation on the spacecraft, the optical designs as well as some of the calibrations, and the expected performances for its three channels are described.
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| 4. |
- Anzellini, S., et al.
(författare)
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Phase diagram of calcium at high pressure and high temperature
- 2018
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Ingår i: Physical Review Materials. - : American Physical Society. - 2475-9953. ; 2:8
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Tidskriftsartikel (refereegranskat)abstract
- Resistively heated diamond-anvil cells have been used together with synchrotron x-ray diffraction to investigate the phase diagram of calcium up to 50 GPa and 800 K. The phase boundaries between the Ca-I (fcc), Ca-II (bcc), and Ca-III (simple cubic, sc) phases have been determined at these pressure-temperature conditions, and the ambient temperature equation of state has been generated. The equation of state parameters at ambient temperature have been determined from the experimental compression curve of the observed phases by using third-order Birch-Murnaghan and Vinet equations. A thermal equation of state was also determined for Ca-I and Ca-II by combining the room-temperature Birch-Murnaghan equation of state with a Berman-type thermal expansion model.
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| 7. |
- Backén, Staffan, et al.
(författare)
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RF replay system for narrowband GNSS if signals
- 2011
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Ingår i: IEEE Transactions on Aerospace and Electronic Systems. - 0018-9251 .- 1557-9603. ; 47:1, s. 586-595
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Tidskriftsartikel (refereegranskat)abstract
- Although GNSS RF signal simulators have long possessed the capability to generate scenarios they are, for example, not yet able to model a realistic scenario with complex multipath. Software defined receivers bridge the gap between simulated and real data to the extent that they may offer a replay capability, where a data set is first recorded to disk and later can be processed several times. Unfortunately, the recorded data generally can not be used by other GNSS receivers, making receiver to receiver comparisons difficult and time consuming.This paper describes a system capable of replaying recorded IF data into any narrow bandwidth L1 GNSS receiver, including an evaluation of the difference (position, timing and SNR) between live and replayed data using a high sensitivity, consumer grade receiver. The performance of the replayed data set was found to match that of the live data.
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| 10. |
- Howcroft, Debra, et al.
(författare)
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Paradoxes of participatory practices : The Janus role of the systems developer
- 2003
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Ingår i: Information and organization. - 1471-7727 .- 1873-7919. ; 13:1, s. 1-24
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Tidskriftsartikel (refereegranskat)abstract
- This paper sets out on a political exploration of the paradoxes of participatory practices which are brought to the fore via the application of a critical framework. In addition, the worker participation literature is used to illuminate some of the contradictions of user participation in Information Systems Development. This approach places emphasis on the fundamentally conflictual nature of organizational relations. The set of resultant paradoxes which this phenomenon engenders is presented. One consequence of the conflictual nature of organizations is the antagonistic relations between end-users (employees) and sponsors of the system (managers). In this paper we highlight the contradictions entailed in the systems developer's role when intervening between the groups, attempting to enrol them into participation as well as develop a system that will deliver on the promises made on its behalf during the enrolment process. The analogy of the two-headed Roman god, Janus, is made in relation to the role of the systems developer, in order to emphasize the incompatibility of needs of organizational members. The paradoxes enumerated in the paper (namely: rhetoric of empowerment, rhetoric of involvement, exclusion of dissent, illusions of compatibility, and outcome of participation) are adjusted to the role of the Janus systems developer, revealing the latter to be a captive of these contradictions. Finally, some conclusions for future academic research and professional practice are drawn
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