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C6-peptide serology...
C6-peptide serology as diagnostic tool in neuroborreliosis
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- Tjernberg, Ivar, 1973- (author)
- Linköpings universitet,Hälsouniversitetet,Infektionsmedicin
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- Schön, Thomas, 1973- (author)
- Linköpings universitet,Hälsouniversitetet,Medicinsk mikrobiologi
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- Ernerudh, Jan, 1952- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin
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- Wistedt, Annika Carlsson (author)
- Clinical Microbiology Kalmar County Hospital, Kalmar
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- Forsberg, Pia, 1949- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Infektionsmedicin,Infektionskliniken i Östergötland
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- Eliasson, Ingvar (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,Department of Clinical Microbiology and Immunology Lund University Hospital
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. - : Wiley. - 1600-0463 .- 0903-4641. ; 116:5, s. 393-399
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Abstract
Subject headings
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- The aim of this study was to evaluate the usefulness of borrelia serology (Quick ELISA C6 Borrelia assay kit) as a diagnostic tool in cases of suspected neuroborreliosis. A retrospective patient material consisting of 124 paired serum and cerebrospinal fluid samples with a positive anti-borrelia antibody index (AI) using the IDEIA Lyme Neuroborreliosis test was compared with 124 Al-negative matched control subjects. The patients were divided into four groups based on presence of pleocytosis and age above or below 12 years. The presence of positive C6 serology in AI-positive patients with pleocytosis was 89% (83/93), significantly different (p < 0.01) from in patients without pleocytosis (58%, 18/31). In AI-positive patients aged >= 12 years with pleocytosis, 94% (51/54) had a positive C6 serology. Of AI-positive patients with a symptom duration of more than 30 days, 93% (27/29) were positive by the C6 test. We conclude that the C6 serum test, together with clinical evaluation, is a powerful diagnostic tool in adult (>= 12 years) European patients with suspected neuroborreliosis with a symptom duration of more than 30 days. Patients with suspected neuroborreliosis and positive C6 results should be further investigated by lumbar puncture for definite diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- cerebrospinal fluid
- Lyme neuroborreliosis
- serology
- pleocytosis
- intrathecal antibodies
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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Tjernberg, Ivar, ...
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Schön, Thomas, 1 ...
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Ernerudh, Jan, 1 ...
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Wistedt, Annika ...
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Forsberg, Pia, 1 ...
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Eliasson, Ingvar
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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APMIS : acta pat ...
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APMIS
- By the university
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Lund University
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Linköping University