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The CCND1 c.870G > ...
The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma
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Weinhold, Niels (author)
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Johnson, David C. (author)
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Chubb, Daniel (author)
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show more...
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Chen, Bowang (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Hosking, Fay J. (author)
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Broderick, Peter (author)
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Ma, Yussanne P. (author)
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Dobbins, Sara E. (author)
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Hose, Dirk (author)
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Walker, Brian A. (author)
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Davies, Faith E. (author)
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Kaiser, Martin F. (author)
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Li, Ni L. (author)
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Gregory, Walter A. (author)
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Jackson, Graham H. (author)
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Witzens-Harig, Mathias (author)
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Neben, Kai (author)
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Hoffmann, Per (author)
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Noethen, Markus M. (author)
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Muehleisen, Thomas W. (author)
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Eisele, Lewin (author)
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Ross, Fiona M. (author)
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Jauch, Anna (author)
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Goldschmidt, Hartmut (author)
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Houlston, Richard S. (author)
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Morgan, Gareth J. (author)
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2013-03-17
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:5, s. 522-525
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http://dx.doi.org/10...
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Abstract
Subject headings
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- A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Weinhold, Niels
-
Johnson, David C ...
-
Chubb, Daniel
-
Chen, Bowang
-
Försti, Asta
-
Hosking, Fay J.
-
show more...
-
Broderick, Peter
-
Ma, Yussanne P.
-
Dobbins, Sara E.
-
Hose, Dirk
-
Walker, Brian A.
-
Davies, Faith E.
-
Kaiser, Martin F ...
-
Li, Ni L.
-
Gregory, Walter ...
-
Jackson, Graham ...
-
Witzens-Harig, M ...
-
Neben, Kai
-
Hoffmann, Per
-
Noethen, Markus ...
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Muehleisen, Thom ...
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Eisele, Lewin
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Ross, Fiona M.
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Jauch, Anna
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Goldschmidt, Har ...
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Houlston, Richar ...
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Morgan, Gareth J ...
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Hemminki, Kari
-
show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Nature Genetics
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Lund University