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- 2019
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Evangelou, Evangelos, et al.
(författare)
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
- 2018
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
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Tidskriftsartikel (refereegranskat)abstract
- High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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| 4. |
- Gao, Yumeng, et al.
(författare)
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Tailoring Self-Assembly of Alternating Copolymers for Ordered and Crystalline 2D Nanostructures via Diverse Strategies
- 2024
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Ingår i: Macromolecules. - 0024-9297 .- 1520-5835. ; 57:12, s. 5656-5665
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Tidskriftsartikel (refereegranskat)abstract
- The pursuit of ordered two-dimensional (2D) materials with customized properties has fueled extensive research. While many established fabrication methods rely on substrates, solution-based polymer self-assembly processes remain much unexplored. Here, by manipulating the delicate balance between dominating and competing forces, we demonstrate how polymer chains fold, self-adjust, and self-assemble into diverse ordered 2D nanostructures in solution guided by an energy landscape, especially highly ordered crystalline structures, which are of great challenge to realize by polymers. An alternating copolymer initially self-assembled into 2D planar flakes via a kinetic pathway, lacking crystallinity. Through thermal annealing, they overcame a local kinetic barrier, in situ transforming into 2D circular crystalline clusters. Furthermore, by facilely replacing alkenyl linkers with triazoles in the alternating copolymers, additional tunable competing interactions were introduced, enabling the system to take thermodynamically favored pathways from the beginning and form 2D crystalline spindles directly. Besides, both the systems exhibited reversible self-assembly behavior and remote-controllable merit under light irradiation, forming 2D crystalline structures including flowers and spindles, respectively, highlighting the systems’ responsiveness and versatility. This study offers diverse and facile strategies for constructing and fine-tuning tailorable nanostructures, suggesting promising applications in precision engineering and biomedical technologies.
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| 5. |
- Gustafsson, Mikaela, et al.
(författare)
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A Family of Flexible Lanthanide Bipyridinedicarboxylate Metal-Organic Frameworks Showing Reversible Single-Crystal to Single-Crystal Transformations
- 2012
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 12:6, s. 3243-3249
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Tidskriftsartikel (refereegranskat)abstract
- A family of flexible lanthanide metal-organic frameworks, [Ln(2)(bpydc)(3)(H2O)(3)]center dot nDMF (denoted as SUMOF-6-Ln; Ln = Nd, Sm, Eu, Gd, Tb, Dy, Ho, and Er, H(2)bpydc =2,2'-bipyridine-5,5'-dicarboxylic acid), was synthesized and characterized. SUMOF-6-Ln has a monoclinic space group P2(1)/c. The three-dimensional framework contains chains of LnO(n) (n = 7-8) polyhedra connected through the bpydc linkers forming 1D rhombic channels along the c-axis. SUMOF-6-Ln showed reversible breathing phenomenon upon desorption/adsorption of the solvent, with up to 27% changes of the unit cell dimensions and 23% changes of the unit cell volume. Single crystal X-ray diffraction (XRD) revealed that the desolvation and resolvation of SUMOF-6-Ln occurred via single-crystal to single-crystal transformations. The thermal behavior of SUMOF-6-Sm was also examined. SUMOF-6-Eu and SUMOF-6-Tb showed solid-state luminescent properties.
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| 6. |
- Liu, Ben, et al.
(författare)
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A facile synthesis of Fe3C@mesoporous carbon nitride nanospheres with superior electrocatalytic activity
- 2016
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 8:10, s. 5441-5445
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Tidskriftsartikel (refereegranskat)abstract
- We report a colloidal amphiphile-templating approach to preparing nanosized Fe3C encapsulated within mesoporous nitrogen-doped carbon nanospheres (Fe3C@mCN). The obtained Fe3C@mCN hybrids having a high surface area and ultrafine Fe3C nanocrystals exhibited superior activity and durability for oxygen reduction.
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| 7. |
- Pascanu, Vlad, et al.
(författare)
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Double-Supported Silica-Metal-Organic Framework Palladium Nanocatalyst for the Aerobic Oxidation of Alcohols under Batch and Continuous Flow Regimes
- 2015
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Ingår i: ACS Catalysis. - : American Chemical Society (ACS). - 2155-5435. ; 5:2, s. 472-479
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Tidskriftsartikel (refereegranskat)abstract
- Stable and easily synthesized metal-organic framework MIL-88B-NH2 represents an attractive support for catalysts employed in oxidation reactions, which are typically performed under relatively harsh conditions. However, MIL-88B-NH2, the thermodynamic polymorph of the more popular MIL-101-NH2, has been rarely employed in catalytic applications because of a difficult impregnation process caused by the flexible nature of the framework. We report herein a new catalyst denoted Pd@MIL-88B-NH2 (8 wt % Pd), the first example of metallic nanoparticles successfully impregnated in the pores of MIL-88B-NH2. Furthermore, by enclosing the MOF crystals in a tailored protective coating of SiO2 nanoparticles, an even more enduring material was developed and applied to the aerobic oxidation of benzylic alcohols. This doubly supported catalyst Pd@MIL-88B-NH2@nano-SiO2 displayed high activity and excellent performance in terms of endurance and leaching control. Under batch conditions, a very convenient and efficient recycling protocol is illustrated, using a teabag approach. Under continuous flow, the catalyst was capable of withstanding 7 days of continuous operation at 110 degrees C without deactivation. During this time, no leaching of metallic species was observed, and the material maintained its structural integrity.
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| 8. |
- Wain, Louise V., et al.
(författare)
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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
- 2017
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Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19
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Tidskriftsartikel (refereegranskat)abstract
- Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
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| 9. |
- Wen, Qin, et al.
(författare)
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Decoding Hosing and Heating Effects on Global Temperature and Meridional Circulations in a Warming Climate
- 2018
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Ingår i: Journal of Climate. - 0894-8755 .- 1520-0442. ; 31:23, s. 9605-9623
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Tidskriftsartikel (refereegranskat)abstract
- The global temperature changes under global warming result from two effects: one is the pure radiative heating effect caused by a change in greenhouse gases, and the other is the freshwater effect related to changes in precipitation, evaporation, and sea ice. The two effects are separated in a coupled climate model through sensitivity experiments in this study. It is indicated that freshwater change has a significant cooling effect that can mitigate the global surface warming by as much as similar to 30%. Two significant regional cooling centers occur: one in the subpolar Atlantic and one in the Southern Ocean. The subpolar Atlantic cooling, also known as the warming hole, is triggered by sea ice melting and the southward cold-water advection from the Arctic Ocean, and is sustained by the weakened Atlantic meridional overturning circulation. The Southern Ocean surface cooling is triggered by sea ice melting along the Antarctic and is maintained by the enhanced northward Ekman flow. In these two regions, the effect of freshwater flux change dominates over that of radiation flux change, controlling the sea surface temperature change in the warming climate. The freshwater flux change also results in the Bjerknes compensation, with the atmosphere heat transport change compensating the ocean heat transport change by about 80% during the transient stage of global warming. In terms of global temperature and Earth's energy balance, the freshwater change plays a stabilizing role in a warming climate.
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| 10. |
- Wilkinson, John L., et al.
(författare)
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Pharmaceutical pollution of the world's rivers
- 2022
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:8
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Tidskriftsartikel (refereegranskat)abstract
- Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world's rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
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