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Sökning: WFRF:(Yoong A)

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  • 2021
  • swepub:Mat__t
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  • Munk, P., et al. (författare)
  • Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
  • 2022
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
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  • Yoong, Li Hsien, et al. (författare)
  • A Synchronous approach for IEC 61499 function block implementation
  • 2009
  • Ingår i: IEEE Transactions on Computers. - 0018-9340 .- 1557-9956. ; 58:12, s. 1599-1614
  • Tidskriftsartikel (refereegranskat)abstract
    • IEC 61499 has been endorsed as the standard for modeling and implementing distributed industrial process measurement and control systems. The standard prescribes the use of function blocks for designing systems in a component-oriented approach. The execution model of a basic function block and the manner for event/data connections between blocks are described therein. Unfortunately, the standard does not provide exhaustive specifications for function block execution. Consequently, multiple standard-compliant implementations exhibiting different behaviors are possible. This not only defeats the purpose of having a standard but also makes verification of function block systems difficult. To overcome this, we propose synchronous semantics for function blocks and show its feasibility by translating function blocks into a subset of Esterel, a well-known synchronous language. The proposed semantics avoids causal cycles common in Esterel and is proved to be reactive and deterministic under any composition. Moreover, verification techniques developed for synchronous systems can now be applied to function blocks.
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