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Sökning: WFRF:(Yue Z)

  • Resultat 1-10 av 44
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1.
  • Kanai, M, et al. (författare)
  • 2023
  • swepub:Mat__t
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  • Campbell, PJ, et al. (författare)
  • Pan-cancer analysis of whole genomes
  • 2020
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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4.
  • Abgrall, N., et al. (författare)
  • The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
  • 2017
  • Ingår i: AIP Conference Proceedings. - : Author(s). - 1551-7616 .- 0094-243X. ; 1894
  • Konferensbidrag (refereegranskat)abstract
    • The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results.
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7.
  • You, Q. L., et al. (författare)
  • Recent frontiers of climate changes in East Asia at global warming of 1.5 degrees C and 2 degrees C
  • 2022
  • Ingår i: npj Climate and Atmospheric Science. - : Springer Science and Business Media LLC. - 2397-3722. ; 5:1
  • Tidskriftsartikel (refereegranskat)abstract
    • East Asia is undergoing significant climate changes and these changes are likely to grow in the future. It is urgent to characterize both the mechanisms controlling climate and the response of the East Asian climate system at global warming of 1.5 and 2 degrees C above pre-industrial levels (GW1.5 and GW2 hereafter). This study reviews recent studies on East Asian climate change at GW1.5 and GW2. The intensity and variability of the East Asian summer monsoon are expected to increase modestly, accompanied by an enhancement of water vapor transport. Other expected changes include the intensification of the Western Pacific Subtropical High and an intensified and southward shift of the East Asian jet, while the intensity of the East Asian winter monsoon is projected to reduce with high uncertainty. Meanwhile, the frequency of ENSO may increase in a warming world with great uncertainty. Significant warming and wetting occur in East Asia, with more pronounced intensity, frequency, and duration of climate extremes at GW2 than that at GW1.5. The fine structure of regional climate changes and the presence and location of various warming hotspots, however, show substantial divergence among different model simulations. Furthermore, the Asian climate responses can differ substantially between the transient and stabilized GW1.5 and GW2, which has important implications for emission policies. Thus, to better plan effective mitigation and adaptation activities, further research including an in-depth exploration of the divergent responses in transient versus stabilized scenarios, the quantification of future projection uncertainties, and improvements of the methods to reduce model uncertainties are required.
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8.
  • Zhang, Shi-Li, et al. (författare)
  • Abnormal anti-Stokes Raman scattering of carbon nanotubes
  • 2002
  • Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 66:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Abnormal anti-Stokes Raman scattering (AASR) was unambiguously observed in carbon nanotubes (CNT's). In contrast to traditional Raman scattering theory, the absolute value of the Raman frequency of the anti-Stokes peak is not the same as that of the corresponding Stokes peak. It was demonstrated that AASR scattering originates from the unique nanoscale cylindrical structure of CNT's that can be considered naturally as a graphite structure with an intrinsic defect from its rolling. The double-resonance Raman scattering theory was applied to interpret the scattering mechanism of the AASR phenomenon successfully and quantitatively.
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9.
  • Barausse, Enrico, et al. (författare)
  • Prospects for fundamental physics with LISA
  • 2020
  • Ingår i: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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10.
  • Fan, W., et al. (författare)
  • Investigation of magnetization dynamics damping in Ni80Fe20/Nd-Cu bilayer at room temperature
  • 2018
  • Ingår i: AIP Advances. - : American Institute of Physics (AIP). - 2158-3226. ; 8:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Focusing on the Ni80Fe20 (Py)/Nd-Cu bilayers, the magnetization dynamic damping from spin pumping effect is investigated systematically by doping itinerant Cu in rear earth metal Nd. Various Ta/Py/Nd1-xCux/Ta/Si films with x = 0%, 16%, 38%, 46% and 58% are prepared by magnetron sputtering. For every content of Cu, the thickness of Nd-Cu layer is changed from 1 nm to 32 nm. The damping coefficient increases with increasing the thickness of Nd-Cu layer, which shows the trend of the spin pumping behavior. Also, with increasing Cu concentration in the Nd-Cu layer, the damping coefficient decreases, implying that the spin-orbit coupling in Nd-Cu layer is indeed cut down by high itinerant of Cu dopants. It is interesting that the spin diffusion length (λSD) in the Nd-Cu layer for different Cu dopants is not found to increase monotonously.
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  • Resultat 1-10 av 44

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