| 1. |
- Thomas, HS, et al.
(författare)
-
- 2019
-
swepub:Mat__t
|
|
| 2. |
|
|
| 3. |
- Ademuyiwa, Adesoji O., et al.
(författare)
-
Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
-
Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
|
|
| 4. |
- Josefson, Lennart, 1954, et al.
(författare)
-
LOAD CAPACITY OF SANDWICH PANEL WITH CORE FOAM EVALUATED BY 3-POINT BENDING TEST
- 2022
-
Ingår i: Proceedings of the International Conference on Offshore Mechanics and Arctic Engineering - OMAE. ; 3
-
Konferensbidrag (refereegranskat)abstract
- The classification society Bureau Veritas requires a structural assessment of composite materials structures to confirm the compliance with applicable rules, like 3-point bending tests. However, for sandwich panels with a low-density foam core, local phenomena like indentation and wrinkling may occur in the upper face sheet at the loading punch, thus the intended load capacity of the sandwich panel will not be reached. It is then proposed to perform complementary shear tests to capture the behaviour of the core of the sandwich panel. In the present paper, the load capacity in a 3-point bending test is simulated with emphasis on the influence of the constitutive modelling of the core foam, as calibrated against experimental results for shear tests. It is carried out as a benchmark exercise, with participation from three universities. The FE-simulations show that the shear test can be used to accurately model the load capacity of the core foam. However, for the 3-point bending test using specimen with a very high panel length/thickness ratio a large part of the load transfer is done in the upper face sheet with less involvement of shear in the core. Although core fracture is observed in the experiments, both the FE-simulated and experimentally found maximum load agree well with the load capacity as determined from analytical formula for local failure in the upper face sheet. The FE-simulated vertical displacement at maximum load differs though.
|
|
| 5. |
- Galluzzi, L, et al.
(författare)
-
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
- 2020
-
Ingår i: Journal for immunotherapy of cancer. - : BMJ. - 2051-1426. ; 8:1
-
Tidskriftsartikel (refereegranskat)abstract
- Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
|
|
