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FBI-1 mRNA in norma...
FBI-1 mRNA in normal mucosa is an independent prognostic factor in colorectal cancer patients
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- Wang, Chao-Jie (author)
- Department of Oncology, Henan Provincial People’s Hospital & People’s Hospital of Henan University, Zheng-zhou, China; Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Zhou, Jian-Wei (author)
- Department of Oncology, Henan Provincial People’s Hospital & People’s Hospital of Henan University, Zheng-zhou, China
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- Cheng, Qiao-Mei (author)
- Department of Oncology, Henan Provincial People’s Hospital & People’s Hospital of Henan University, Zheng-zhou, China
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- Zhou, Yun (author)
- Department of Oncology, Henan Provincial People’s Hospital & People’s Hospital of Henan University, Zheng-zhou, China
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- Zhang, Hong, 1957- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Sun, Xiao-Feng (author)
- Department of Oncology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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(creator_code:org_t)
- e-Century Publishing, 2018
- 2018
- English.
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In: International Journal of Clinical and Experimental Pathology. - : e-Century Publishing. - 1936-2625. ; 11:2, s. 642-649
- Related links:
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https://e-century.us...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Although several studies provide evidence that FBI-1 is an important gene regulator in colorectal cancer (CRC), it is noteworthy that, to our knowledge, no analysis of the correlation between FBI-1 expression and prognosis in CRC has been reported. Using real-time RT-PCR, we detected FBI-1 mRNA in 161 CRC patients (primary tumor, along with the corresponding normal mucosa), 36 liver metastases, and analyzed the relationship of its expression with clinicopathological features. Colon cancer cell lines were used to study FBI-1 function. Our study found that FBI-1 was significant up-regulated in tumor tissue (2.621 +/- 0.157) compared with the corresponding normal mucosa (1.620 +/- 0.165, P < 0.0001). FBI-1 in normal mucosa was a prognostic factor (P = 0.039, RR 0.431, 95% CI 0.194-0.958), independent of gender, age, stage, and differentiation. High levels of FBI-1 mRNA were related with good survival. Patients with complications had a higher primary tumor FBI-1 expression than those without complications (3.400 +/- 0.332 vs. 2.516 +/- 0.241, P = 0.032). Suppression of FBI-1 in colon cancer cell lines could repress proliferation of cancer cells. In conclusion, FBI-1 mRNA is overexpressed in CRC, and takes part in the development of CRC. FBI-1 mRNA in normal mucosa is an independent prognostic factor. Our findings give further support to the concept of "field cancerization", and hint that when we study a biomarker, we should not only focus on the tumor tissue but also the corresponding normal mucosa.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colorectal cancer
- FBI-1
- prognosis
- biomarker
- field cancerization
Publication and Content Type
- ref (subject category)
- art (subject category)
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