| 1. |
- Atif, Yacine, et al.
(författare)
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Network Resource Management in Support of QoS in Ubiquitous Learning
- 2014
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Ingår i: Journal of Network and Computer Applications. - Netherlands : Elsevier. - 1084-8045 .- 1095-8592. ; 41, s. 148-156
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Tidskriftsartikel (refereegranskat)abstract
- Ubiquitous learning involves a large-scale service network organized as a social infrastructure. These environments weave together context service dissemination, learner profiling as well as autonomic control of the induced network traffic. The objective of the research presented in this paper is to derive a Quality of Service aware model of ubiquitous learning services based on typical learning schemes. These pedagogical patterns are designed to match various learning situations in terms of learning context, learner profile and network infrastructure. They particularly represent classes of services in ubiquitous learning environments to prioritize traffic so that less important traffic does not consume network bandwidth and slow down or halt the delivery of more important traffic. We analyze formally and empirically the network traffic requirements of a proposed learning service quality controller to support providers of learning services allocating resources in a pervasive learning environment.
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| 2. |
- Figueroa, Jonine D., et al.
(författare)
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Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry
- 2016
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 25:6, s. 1203-1214
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Tidskriftsartikel (refereegranskat)abstract
- Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10−6), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10−11) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10−10). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region—the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r2 = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case–case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.
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| 3. |
- Han, Ziming, et al.
(författare)
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Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment: Cumulative Effect on Soil Antibiotic Resistance Genes
- 2022
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Ingår i: Engineering. - : Elsevier BV. - 2095-8099. ; 15, s. 78-88
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Tidskriftsartikel (refereegranskat)abstract
- Fermentation-based antibiotic production results in abundant nutrient-rich fermentation residue with high potential for recycling, but the high antibiotic residual concentration restricts its usefulness (e.g., in land application as organic fertilizer). In this study, an industrial-scale hydrothermal facility for the treatment of erythromycin fermentation residue (EFR) was investigated, and the potential risk of the long-term soil application of treated EFR promoting environmental antibiotic resistance development was evaluated. The treatment effectively removed bacteria and their DNA, and an erythromycin removal ratio of up to approximately 98% was achieved. The treated EFR was utilized as organic fertilizer for consecutive field applications from 2018 to 2020, with dosages ranging from 3750 to 15 000 kg∙hm−2, resulting in sub-inhibitory levels of erythromycin (ranging from 0.83–76.00 μg∙kg−1) in soils. Metagenomic shotgun sequencing was then used to characterize the antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and bacterial community composition of the soils. The soil ARG abundance and diversity did not respond to the treated EFR application in the first year, but gradually changed in the second and third year of application. The highest fold change in relative abundance of macrolide–lincosamide–streptogramin (MLS) and total ARGs were 12.59 and 2.75 times, compared with the control (CK; without application), respectively. The soil MGEs and taxonomic composition showed similar temporal trends to those of the ARGs, and appeared to assist in driving increasing ARG proliferation, as revealed by correlation analysis and structural equation models (SEMs). The relative abundance of particular erm resistance genes (RNA methyltransferase genes) increased significantly in the third year of treated EFR application. The close association of erm with MGEs suggested that horizontal gene transfer played a critical role in the observed erm gene enrichment. Metagenomic binning results demonstrated that the proliferation of mac gene-carrying hosts was responsible for the increased abundance of mac genes (efflux pump genes). This study shows that sub-inhibitory levels of erythromycin in soils had a cumulative effect on soil ARGs over time and emphasizes the importance of long-term monitoring for assessing the risk of soil amendment with treated industrial waste.
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| 4. |
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| 5. |
- Ren, Guobin, et al.
(författare)
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Design of all-solid bandgap fiber with improved confinement and bend losses
- 2006
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Ingår i: IEEE Photonics Technology Letters. - : IEEE. - 1041-1135 .- 1941-0174. ; 18:24, s. 2560-2562
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Tidskriftsartikel (refereegranskat)abstract
- We propose a new design of low-contrast all-solid bandgap fiber with low confinement and bend losses within low-order bandgaps. By introducing an index depressed layer around the high index rod in fiber cladding, we theoretically predict that the confinement loss of the proposed all-solid bandgap fiber would be significantly improved. Due to the enlarged index mismatch of the guided core mode and the edge of the bandgaps, the critical bend radius of the proposed fiber is remarkably reduced.
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