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- Brunk, Ulf, et al.
(författare)
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Septic shock and the lysosomal-mitochondrial axis theory of apoptosis
- 2009
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Ingår i: Molecular Mechanism of Severe Shock. - Kerala, India : Research Signpost. - 9788130803388 ; , s. 91-106
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Over 250 years ago, Le Dran, a distinguished French Surgeon, first used the word “shock” in his treatise. Since then, much progress has been made in shock research. However, many questions have still confused the medical doctors until now. For example, why the reduced blood pressure can’t return to normal after anti-shock treatment in severe shock, why the high mortality of septic shock can’t be reduced though many new therapies are reported, what is the reason for the development of systemic inflammatory response syndrome and multiple organ dysfunction syndrome following a prolonged severe shock, and what event triggers the connection among shock, systemic inflammation, and multi-organ dysfunction, etc. In order to resolve these questions, research on the pathogenesis of shock has been made at molecular level in recent years. Current advances of shock molecular mechanism are presented in this book, which is divided into 10 chapters, including new theory about auto-digestion in shock and organ failure, septic shock and the lysosomal-mitochondrial axis theory in apoptosis, molecular mechanism of endotoxin action, HMGB-1 and sepsis after burns, role of MAPK in inflammation and septic shock, ion channels and low vasoreactivity in severe shock, vascular permeability in shock, lymphatic microcirculation and shock, calcium signaling in cardiac dysfunction of burns, the effect and mechanism of a new anti-shock medicine Polydatin. We hope that these chapters will help the readers to develop strategies and tactics that will promote shock research. We want to thank all the authors for their excellent cooperation and manuscript preparation. We also give special thanks to Dr. Pandalai for inviting us to edit and publish this review book in Research Signpost
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| 2. |
- He, Chao, et al.
(författare)
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A clinical study of high-dose urokinase for the treatment of the patients with hypertension induced ventricular hemorrhage
- 2021
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Ingår i: Brain protection strategies and nanomedicine. - : Elsevier BV. - 9780323989275 ; , s. 349-355
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Bokkapitel (refereegranskat)abstract
- Objective: This study discusses the therapeutic effect of high-dose urokinase treatment for hypertension ventricular hemorrhage.Methods: A total of 60 patients with hypertension ventricular hemorrhage were randomly assigned to two groups: treatment group (n = 30)and control group (n = 30). Both groups received bilateral external ventricular drain. The treatment group was injected with 50,000 IU urokinase to the lateral ventricle every day; the total injection volume per day was 100,000 IU. The control group was injected with 20,000 IU urokinase to the lateral ventricle every day with a total injection volume per day of 40,000 IU. Lumbar puncture was performed in both groups after the later ventricular drain was removed to release cerebrospinal fluid (CSF). Head Computed tomography(CT) examination was performed regularly to observe changes in the ventricular hematoma as well as the occurrence of complications such as intracranial infection and hydrocephalus. Patient prognosis 6 weeks after surgery was compared between the two groups.Results: In the treatment group, the intraventricular hemorrhage clearance time and the number of instances of urokinase treatment were significantly less than those of the control group (P<0.05). The total urokinase dosage of the treatment group was significantly higher than that of the control group (P<0.05). With respect to post-surgery complications, in the treatment group, there were three cases of hydrocephalus and one case of intracranial infection. In the control group, there were four cases of hydrocephalus and three cases of intracranial infection. Intraventricular re-hemorrhage was not observed in either group. Intracranial infection was relieved after strengthened anti-infective therapy and continuous drainage. There was a statistically significant difference in the occurrence of complications between the treatment group and the control group (P<0.05). The rate of good prognosis in the treatment group was higher than that of the control group (P<0.05), and the inefficiency rate was lower (P<0.05).Conclusions: High-dose urokinase treatment produces a significant therapeutic effect in hypertension ventricular hemorrhage. This treatment can quickly eliminate intraventricular hemorrhage, shorten the ventricular drain tube indwelling time, decrease the occurrence of intracranial infection, and increase the likelihood of a good prognosis.
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| 3. |
- He, Chao, et al.
(författare)
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Diagnosis experience and literature review of patients with cervical, thoracic and lumbar multi-segment spinal stenosis : A case report
- 2021
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Ingår i: Brain protection strategies and nanomedicine. - : Elsevier BV. - 9780323989275 ; , s. 377-385
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Bokkapitel (refereegranskat)abstract
- Background: The incidence of cervical, thoracic and lumbar spinal canal stenosis is low. It is difficult to identify the main focus and responsible segment, and it is also difficult to select the sequence of staging surgery. We report a patient with triple stenosis.Case presentation: In this paper, we introduced a 61-year-old female patient with cervical, thoracic and lumbar spinal canal stenosis who had previously undergone "lumbar discectomy" in the outer hospital. The postoperative effect was not good and the symptoms were poor. The diagnosis was "cervical spinal stenosis and lumbar spine surgery." The staged spinal canal decompression operation and Duhuo Jisheng Decoction (DHJSD) treatment were conducted in our hospital. After 3 months of follow-up, the functional and imaging results were satisfactory.Conclusion: We should pay enough attention to the patients with spinal degenerative diseases who need surgery, and must pursue the unity of medical history, signs and images. In case of difficult patients, more comprehensive examination is required, and the main focus and responsible segment are determined through comprehensive analysis. The more important diseases that may exist cannot be covered up by focal lesion manifestations, so as to avoid unnecessary surgical trauma for patients. In addition, surgery combined with Chinese herbal medicine DHJSD therapy may be an effective treatment for this kind of disease.
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