| 1. |
- Álvaro, J. Javier, et al.
(författare)
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Global Cambrian trilobite palaeobiogeography assessed using parsimony analysis of endemicity
- 2013
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Ingår i: Early Palaeozoic Biogeography and Palaeogeography. - 0435-4052. - 9781862393738 ; Memoir 38:38, s. 273-296
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Bokkapitel (refereegranskat)abstract
- Palaeobiogeographical data on Cambrian trilobites obtained during the twentieth century are combined in this paper to evaluate palaeoceanographic links through c. 30 myr, once these arthropods biomineralized. Worldwide major tectonostratigraphic units are characterized at series intervals of Cambrian time and datasets of trilobite genera (629 for Cambrian Series 2, 965 for Cambrian Series 3, and 866 for the Furongian Series) are analysed using parsimony analysis of endemicity. Special attention is given to the biogeographical observations made in microcontinents and exotic terranes. The same is done for platform-basinal transects of well-known continental margins. The parsimony analysis of endemicity analysis resulted in distinct palaeogeographical area groupings among the tectonostratigraphic units. With these groupings, several palaeobiogeographical units are distinguished, which do not necessarily fit the previously proposed biogeographical realms and provinces. Their development and spatial distributions are broadly controlled by Cambrian palaeoclimates, palaeogeographical conditions (e.g. carbonate productivity and anoxic conditions) and ocean current circulation.
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| 2. |
- Liotta, L. A., et al.
(författare)
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Clinical proteomics and molecular pathology
- 2017
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Ingår i: Molecular Pathology: The Molecular Basis of Human Disease. - : Elsevier Inc.. - 9780128027615 ; , s. 183-203
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease.
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| 3. |
- Liotta, Lance A., et al.
(författare)
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Clinical proteomics and molecular pathology
- 2020
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Ingår i: Essential Concepts in Molecular Pathology. - : Elsevier BV. ; , s. 149-163
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease.
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| 4. |
- Rogelj, Joeri, et al.
(författare)
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Mitigation pathways compatible with 1.5°C in the context of sustainable development
- 2018
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Ingår i: Global Warming of 1.5°C. An IPCC Special Report on the impacts of global warming of 1.5°C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicate poverty. ; , s. 93-174
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Bokkapitel (refereegranskat)
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