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1.	Kato, Norihiro, et al. (author) Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation 2015 In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 47:11, s. 1282-1293 Journal article (peer-reviewed)abstract We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.
2.	Zanchetti, Alberto, et al. (author) Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial. 2014 In: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1888-1897 Journal article (peer-reviewed)abstract The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.
3.	Zanchetti, Alberto, et al. (author) Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. 2014 In: Journal of Hypertension. - 1473-5598. ; 32:9, s. 1741-1750 Research review (peer-reviewed)abstract It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.
4.	Zanchetti, Alberto, et al. (author) Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT: rationale for further study on blood pressure targets of antihypertensive treatment after stroke. 2016 In: Journal of Hypertension. - 1473-5598. ; 34:3, s. 393-396 Journal article (peer-reviewed)

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Type of publication: journal article (3); research review (1)

Type of content: peer-reviewed (4)

Author/Editor: Zhu, Dingliang (4); Nilsson, Peter (3); Coca, Antonio (3); Rodicio, Jose Luis (3); Silani, Vincenzo (3); Laurent, Stephane (3); show more...; Berge, Eivind (3); Zhang, Yuqing (3); Pinto, Fernando (3); Banach, Maciej (3); Viigimaa, Margus (3); Dicker, Dror (3); O'Brien, John (3); Zambon, Antonella (3); Corrao, Giovanni (3); Cifkova, Renata (3); Jelakovic, Bojan (3); Redon, Josep (3); Scotti, Lorenza (3); Narkiewicz, Krzyszto ... (3); Liu, Lisheng (3); Parati, Gianfranco (3); Grassi, Guido (3); Mancia, Giuseppe (3); Burnier, Michel (3); Schmieder, Roland E. (3); Dominiczak, Anna (3); Dorobantu, Maria (3); Zanchetti, Alberto (3); Manolis, Athanasios ... (3); Lovic, Dragan (3); Stramba-Badiale, Mar ... (3); Agabiti-Rosei, Enric ... (3); Farsang, Csaba (3); Ruilope, Luis Miguel (3); Sirenko, Yuriy (3); Konradi, Alexandra (3); Bilo, Grzegorz (3); Postadzhiyan, Arman (3); Zhang, Xinhua (3); Zhang, Xuezhong (3); Guan, Ting Rui (3); Wu, Zhaosu (3); Martell-Claros, Niev ... (3); Lazareva, Irina (3); Accetto, Rok (3); Stylianou, Philippos (3); Wei, Gangzhi (3); Xu, Chengbin (3); Xie, Hengge (3); show less...

University: Lund University (4); Umeå University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (4)

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