| 1. |
- Magnusson, Patrik K. E., et al.
(författare)
-
The Swedish Twin Registry : establishment of a biobank and other recent developments
- 2013
-
Ingår i: Twin Research and Human Genetics. - Cambridge, United Kingdom : Cambridge University Press. - 1832-4274 .- 1839-2628. ; 16:1, s. 317-329
-
Tidskriftsartikel (refereegranskat)abstract
- The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
|
|
| 2. |
- Rosell, Magdalena, et al.
(författare)
-
Contribution of a manually coded part in an optically readable, precoded sevenday food record for the intake of energy, nutrients and foods
- 2003
-
Ingår i: Scandinavian Journal of Nutrition/Næringsforskning. - : Informa UK Limited. - 1102-6480 .- 1651-2359. ; 47:3, s. 123-131
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: This study investigated the contribution of a manually coded part (MP) in a precoded 7 day food record for the intake of energy, nutrients and foods. Design: The dietary intake was assessed in a cross-sectional study using an optically readable precoded 7 day food record. Biological markers for the intakes of protein, sodium and potassium were measured in 24 h urine samples. Underreporters were identified according to the Goldberg cut-off for energy intake:basal metabolic rate. The study setting was an outpatient clinic at Karolinska Hospital, Stockholm, Sweden. The subjects were 301 healthy men aged 63 years. Results: The MP represented 20% of the energy intake. Intakes recorded as free text were foods commonly eaten between meals, especially in the evening and were, with the exception of fruits, characterized as less healthy. The agreement between using the food record with and without the MP, respectively, was low for energy, carbohydrates, a-tocopherol and vitamin C, and high for retinol, vitamin D and vitamin B12. Underreporters recorded their food intake as free text to a lesser degree than did non-underreporters. When the MP was included in the food record, the percentage of energy from fat and carbohydrates increased and the percentage of energy from protein decreased. The biological markers for protein, sodium and potassium confirmed an improved validity of the dietary data when the MP was included. Conclusions: Inclusion of the food consumption recorded in free text influenced the dietary quality and indicated improved validity of the optically readable precoded food record. To increase the possibility of catching underreporting in dietary surveys, these findings emphasize the importance of the recording/ reporting of between-meal eating. Keywords: biological markers; dietary assessment; in-between meals; precoded food record; underreporting.
|
|
