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Current challenges ...
Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network
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- Vinarov, Zahari (author)
- Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium; Sofia Univ, Dept Chem & Pharmaceut Engn, Sofia, Bulgaria
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- Abrahamsson, Bertil (author)
- AstraZeneca, Operat, Pharmaceut Technol & Dev, Oral Prod Dev, Gothenburg, Sweden
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- Artursson, Per (author)
- Uppsala universitet,Institutionen för farmaci
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- Batchelor, Hannah (author)
- Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
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- Berben, Philippe (author)
- UCB Pharma SA, Pharmaceut Dev, Braine Lalleud, Belgium
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- Bernkop-Schnürch, Andreas (author)
- Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria
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- Butler, James (author)
- GlaxoSmithKline Res & Dev Ltd, Ware, Herts, England
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- Ceulemans, Jens (author)
- Janssen Pharmaceut NV, Beerse, Belgium
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- Davies, Nigel (author)
- AstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden
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- Dupont, Didier (author)
- STLO, Inst Agro, INRAE, Rennes, France
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- Flaten, Gøril Eide (author)
- UiT Arctic Univ Norway, Dept Pharm, Tromsø, Norway
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- Fotaki, Nikoletta (author)
- Univ Bath, Dept Pharm & Pharmacol, Bath, Avon, England
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- Griffin, Brendan T. (author)
- Univ Coll Cork, Sch Pharm, Cork, Ireland
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- Jannin, Vincent (author)
- Lonza Pharma & Biotech, Colmar, France
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- Keemink, Janneke (author)
- Janssen Pharmaceut NV, Beerse, Belgium
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- Kesisoglou, Filippos (author)
- Merck & Co Inc, Pharmaceut Sci, Rahway, NJ 07065 USA
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- Koziolek, Mirko (author)
- Abbvie Deutschland GmbH & Co KG, Ludwigshafen, Germany
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- Kuentz, Martin (author)
- Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland
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- Mackie, Alan (author)
- Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England
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- Meléndez-Martínez, Antonio J. (author)
- Univ Seville, Food Colour & Qual Lab, Area Nutr & Food Sci, Seville, Spain
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- McAllister, Mark (author)
- Pfizer PGRD, Drug Prod Design, Sandwich, Kent, England
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- Müllertz, Anette (author)
- Univ Copenhagen, Dept Pharm, Copenhagen, Denmark
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- O'Driscoll, Caitriona M. (author)
- Univ Coll Cork, Sch Pharm, Cork, Ireland
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- Parrott, Neil (author)
- F Hoffmann La Roche Ltd, Basel, Switzerland
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- Paszkowska, Jadwiga (author)
- Physiolut Polska Sp Zoo, Wroclaw, Poland
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- Pavek, Petr (author)
- Charles Univ Prague, Fac Pharm, Hradec Kralove, Czech Republic
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- Porter, Christopher J. H. (author)
- Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia
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- Reppas, Christos (author)
- Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece
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- Stillhart, Cordula (author)
- F Hoffmann La Roche Ltd, Basel, Switzerland
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- Sugano, Kiyohiko (author)
- Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Shiga, Japan
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- Toader, Elena (author)
- Univ Med & Pharm Iasi, Fac Med, Iasi, Romania
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- Valentová, Katerina (author)
- Czech Acad Sci, Inst Microbiol, Prague, Czech Republic
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- Vertzoni, Maria (author)
- Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece
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- De Wildt, Saskia N. (author)
- Radboud Univ Nijmegen Med Ctr, Dept Pharmacol & Toxicol, Nijmegen, Netherlands
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- Wilson, Clive G. (author)
- Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
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- Augustijns, Patrick (author)
- Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: Advanced Drug Delivery Reviews. - : Elsevier. - 0169-409X .- 1872-8294. ; 171, s. 289-331
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
Close
- Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Specific patient populations
- Regional differences
- Advanced formulations
- Amorphous solid dispersions
- Lipid-based formulations
- Food-drug interactions
- Microbiome
- In vitro tools
- PBPK modeling
Publication and Content Type
- ref (subject category)
- for (subject category)
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To the university's database
- By the author/editor
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Vinarov, Zahari
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Abrahamsson, Ber ...
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Artursson, Per
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Batchelor, Hanna ...
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Berben, Philippe
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Bernkop-Schnürch ...
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show more...
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Butler, James
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Ceulemans, Jens
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Davies, Nigel
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Dupont, Didier
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Flaten, Gøril Ei ...
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Fotaki, Nikolett ...
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Griffin, Brendan ...
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Jannin, Vincent
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Keemink, Janneke
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Kesisoglou, Fili ...
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Koziolek, Mirko
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Kuentz, Martin
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Mackie, Alan
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Meléndez-Martíne ...
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McAllister, Mark
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Müllertz, Anette
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O'Driscoll, Cait ...
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Parrott, Neil
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Paszkowska, Jadw ...
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Pavek, Petr
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Porter, Christop ...
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Reppas, Christos
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Stillhart, Cordu ...
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Sugano, Kiyohiko
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Toader, Elena
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Valentová, Kater ...
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Vertzoni, Maria
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De Wildt, Saskia ...
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Wilson, Clive G.
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Augustijns, Patr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Advanced Drug De ...
- By the university
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Uppsala University