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Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network

Vinarov, Zahari (author)
Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium; Sofia Univ, Dept Chem & Pharmaceut Engn, Sofia, Bulgaria
Abrahamsson, Bertil (author)
AstraZeneca, Operat, Pharmaceut Technol & Dev, Oral Prod Dev, Gothenburg, Sweden
Artursson, Per (author)
Uppsala universitet,Institutionen för farmaci
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Batchelor, Hannah (author)
Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
Berben, Philippe (author)
UCB Pharma SA, Pharmaceut Dev, Braine Lalleud, Belgium
Bernkop-Schnürch, Andreas (author)
Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria
Butler, James (author)
GlaxoSmithKline Res & Dev Ltd, Ware, Herts, England
Ceulemans, Jens (author)
Janssen Pharmaceut NV, Beerse, Belgium
Davies, Nigel (author)
AstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden
Dupont, Didier (author)
STLO, Inst Agro, INRAE, Rennes, France
Flaten, Gøril Eide (author)
UiT Arctic Univ Norway, Dept Pharm, Tromsø, Norway
Fotaki, Nikoletta (author)
Univ Bath, Dept Pharm & Pharmacol, Bath, Avon, England
Griffin, Brendan T. (author)
Univ Coll Cork, Sch Pharm, Cork, Ireland
Jannin, Vincent (author)
Lonza Pharma & Biotech, Colmar, France
Keemink, Janneke (author)
Janssen Pharmaceut NV, Beerse, Belgium
Kesisoglou, Filippos (author)
Merck & Co Inc, Pharmaceut Sci, Rahway, NJ 07065 USA
Koziolek, Mirko (author)
Abbvie Deutschland GmbH & Co KG, Ludwigshafen, Germany
Kuentz, Martin (author)
Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland
Mackie, Alan (author)
Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England
Meléndez-Martínez, Antonio J. (author)
Univ Seville, Food Colour & Qual Lab, Area Nutr & Food Sci, Seville, Spain
McAllister, Mark (author)
Pfizer PGRD, Drug Prod Design, Sandwich, Kent, England
Müllertz, Anette (author)
Univ Copenhagen, Dept Pharm, Copenhagen, Denmark
O'Driscoll, Caitriona M. (author)
Univ Coll Cork, Sch Pharm, Cork, Ireland
Parrott, Neil (author)
F Hoffmann La Roche Ltd, Basel, Switzerland
Paszkowska, Jadwiga (author)
Physiolut Polska Sp Zoo, Wroclaw, Poland
Pavek, Petr (author)
Charles Univ Prague, Fac Pharm, Hradec Kralove, Czech Republic
Porter, Christopher J. H. (author)
Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia
Reppas, Christos (author)
Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece
Stillhart, Cordula (author)
F Hoffmann La Roche Ltd, Basel, Switzerland
Sugano, Kiyohiko (author)
Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Shiga, Japan
Toader, Elena (author)
Univ Med & Pharm Iasi, Fac Med, Iasi, Romania
Valentová, Katerina (author)
Czech Acad Sci, Inst Microbiol, Prague, Czech Republic
Vertzoni, Maria (author)
Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece
De Wildt, Saskia N. (author)
Radboud Univ Nijmegen Med Ctr, Dept Pharmacol & Toxicol, Nijmegen, Netherlands
Wilson, Clive G. (author)
Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland
Augustijns, Patrick (author)
Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium
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 (creator_code:org_t)
Elsevier, 2021
2021
English.
In: Advanced Drug Delivery Reviews. - : Elsevier. - 0169-409X .- 1872-8294. ; 171, s. 289-331
  • Research review (peer-reviewed)
Abstract Subject headings
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  • Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

Specific patient populations
Regional differences
Advanced formulations
Amorphous solid dispersions
Lipid-based formulations
Food-drug interactions
Microbiome
In vitro tools
PBPK modeling

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