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Genetic Variants As...
Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study
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Castaldo, L (author)
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- Laguzzi, F (author)
- Karolinska Institutet
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- Strawbridge, RJ (author)
- Karolinska Institutet
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Baldassarre, D (author)
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Veglia, F (author)
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Vigo, L (author)
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Tremoli, E (author)
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- de Faire, U (author)
- Karolinska Institutet
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- Eriksson, P (author)
- Karolinska Institutet
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Smit, AJ (author)
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Aubrecht, J (author)
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- Leander, K (author)
- Karolinska Institutet
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Pirro, M (author)
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Giral, P (author)
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Ritieni, A (author)
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Di Minno, G (author)
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- Malarstig, A (author)
- Karolinska Institutet
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- Gigante, B (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-22
- 2020
- English.
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In: Genes. - : MDPI AG. - 2073-4425. ; 11:11
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis-related cardiovascular diseases (CVD) share common metabolic pathways. We explored the association between three NAFLD-associated single nucleotide polymorphisms (SNPs) rs738409, rs10401969, and rs1260326 with sub-clinical atherosclerosis estimated by the carotid intima-media thickness (c-IMT) and the inter-adventitia common carotid artery diameter (ICCAD) in patients free from clinically overt NAFLD and CVD. The study population is the IMPROVE, a multicenter European study (n = 3711). C-IMT measures and ICCAD were recorded using a standardized protocol. Linear regression with an additive genetic model was used to test for association of the three SNPs with c-IMT and ICCAD. In secondary analyses, the association of the three SNPs with c-IMT and ICCAD was tested after stratification by alanine aminotransferase levels (ALT). No associations were found between rs738409, rs1260326, rs10401969, and c-IMT or ICCAD. Rs738409-G and rs10401969-C were associated with ALT levels (p < 0.001). In patients with ALT levels above 28 U/L (highest quartile), we observed an association between rs10401969-C and c-IMT measures of c-IMTmax and c-IMTmean-max (p = 0.018 and 0.021, respectively). In conclusion, NAFLD-associated SNPs do not associate with sub-clinical atherosclerosis measures. However, our results suggest a possible mediating function of impaired liver function on atherosclerosis development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- By the author/editor
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Castaldo, L
-
Laguzzi, F
-
Strawbridge, RJ
-
Baldassarre, D
-
Veglia, F
-
Vigo, L
-
show more...
-
Tremoli, E
-
de Faire, U
-
Eriksson, P
-
Smit, AJ
-
Aubrecht, J
-
Leander, K
-
Pirro, M
-
Giral, P
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Ritieni, A
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Di Minno, G
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Malarstig, A
-
Gigante, B
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Karolinska Institutet