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Longer leukocyte te...
Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects
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Wikgren, Mikael (författare)
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Karlsson, Thomas (författare)
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Lind, Johanna (författare)
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Nilbrink, Therese (författare)
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Hultdin, Johan (författare)
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Sleegers, Kristel (författare)
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Van Broeckhoven, Christine (författare)
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Roos, Göran (författare)
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Nilsson, Lars Göran, 1944- (författare)
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Nyberg, Lars (författare)
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Adolfsson, Rolf (författare)
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Norrback, Karl-Fredrik (författare)
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- Public Library of Science, 2012
- 2012
- Engelska.
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Ingår i: PLoS ONE. - 1932-6203. ; 7:4, e34292
- Relaterad länk:
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http://www.umu.se/ (web site)
Abstract
Ämnesord
Stäng
- Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.
Ämnesord
- Medical and Health Sciences (ssif)
- Basic Medicine (ssif)
- Neurosciences (ssif)
- Medicin och hälsovetenskap (ssif)
- Medicinska och farmaceutiska grundvetenskaper (ssif)
- Neurovetenskaper (ssif)
Genre
- government publication (marcgt)
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PLoS ONE
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Wikgren, Mikael
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Karlsson, Thomas
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Lind, Johanna
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Nilbrink, Theres ...
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Hultdin, Johan
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Sleegers, Kriste ...
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visa fler...
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Van Broeckhoven, ...
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Roos, Göran
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Nilsson, Lars Gö ...
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Nyberg, Lars
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Adolfsson, Rolf
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Norrback, Karl-F ...
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visa färre...
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