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Sökning: WFRF:(Arora M) > (2005-2009)

  • Resultat 1-7 av 7
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  • Ringden, O, et al. (författare)
  • The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation
  • 2009
  • Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 113:13, s. 3110-3118
  • Tidskriftsartikel (refereegranskat)abstract
    • Do some patients benefit from an unrelated donor (URD) transplant because of a stronger graft-versus-leukemia (GVL) effect? We analyzed 4099 patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML) undergoing a myeloablative allogeneic hematopoietic cell transplantation (HCT) from an URD (8/8 human leukocyte antigen [HLA]–matched, n = 941) or HLA-identical sibling donor (n = 3158) between 1995 and 2004 reported to the CIBMTR. In the Cox regression model, acute and chronic GVHD were added as time-dependent variables. In multivariate analysis, URD transplant recipients had a higher risk for transplantation-related mortality (TRM; relative risk [RR], 2.76; P < .001) and relapse (RR, 1.50; P < .002) in patients with AML, but not ALL or CML. Chronic GVHD was associated with a lower relapse risk in all diagnoses. Leukemia-free survival (LFS) was decreased in patients with AML without acute GVHD receiving a URD transplant (RR, 2.02; P < .001) but was comparable to those receiving HLA-identical sibling transplants in patients with ALL and CML. In patients without GVHD, multivariate analysis showed similar risk of relapse but decreased LFS for URD transplants for all 3 diagnoses. In conclusion, risk of relapse was the same (ALL, CML) or worse (AML) in URD transplant recipients compared with HLA-identical sibling transplant recipients, suggesting a similar GVL effect.
  • Nagarajan, A., et al. (författare)
  • On the applicability of trusted computing in distributed authorization using Web services
  • 2008
  • Konferensbidrag (refereegranskat)abstract
    • Distributed authorization provides the ability to control access to resources spread over the Internet. Typical authorization systems consider a range of security information like user identities, role identities or even temporal, spatial and contextual information associated with the access requestor. However, the ability to include computing platform related information has been quite limited due to constraints in identification and validation of platforms when distributed. Trusted computing is an exciting technology that can provide new ways to bridge this gap. In this paper, we provide the first steps necessary to achieving distributed authorization using trusted computing platforms. We introduce the notion of a Property Manifest that can be used in the specification of authorization policies. We provide an overview of our authorization architecture, its components and functions. We then illustrate the applicability of our system by implementing it in a Web service oriented architecture.
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  • Resultat 1-7 av 7

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