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- Aarsland, D, et al.
(författare)
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Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria
- 2008
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 26:5, s. 445-452
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Tidskriftsartikel (refereegranskat)abstract
- <i>Objective:</i> To find the proportion of dementia with Lewy bodies (DLB) in a referral cohort of patients with a first-time diagnosis of mild dementia. <i>Background:</i> The proportion of DLB among the dementia sufferers is not known and the clinical consensus criteria have low sensitivity. We employed the revised DLB criteria to study the proportion with DLB in a community sample of patients with mild dementia. <i>Methods:</i> From March 2005 to March 2007, we included 196 patients from referrals to all geriatric medicine, old age psychiatry and neurology outpatient clinics in Rogaland and Hordaland counties in Western Norway. Standardized clinical instruments and diagnostic criteria were employed. <i>Results:</i> 65% had Alzheimer dementia, 20% DLB (16% probable DLB), 5.6% vascular dementia, 5.6% Parkinson disease with dementia, 2.0% frontotemporal dementia and 1.5% alcoholic dementia. There were no significant differences in the proportion with DLB according to age bands and dementia severity groups. The revised criteria for a clinical diagnosis of DLB increased the proportion of probable DLB by 25% compared to the previous criteria. <i>Conclusion:</i> DLB is common in patients with mild dementia, and is the second most common type of dementia. The introduction of new clinical criteria for DLB leads to an increase in the proportion diagnosed with probable DLB.
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| 4. |
- Sharp, SI, et al.
(författare)
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Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia
- 2008
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 26:4, s. 330-338
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Tidskriftsartikel (refereegranskat)abstract
- <i>Background:</i> Serotonin 1A receptors (5-HT<sub>1A</sub>) have not been studied in dementia with Lewy bodies (DLB) or Parkinson’s disease dementia (PDD) patients with depression. <i>Aim:</i> To examine 5-HT<sub>1A</sub> in DLB and PDD postmortem in relation to depression. <i>Methods:</i> [<sup>3</sup>H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT<sub>1A</sub> was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls. <i>Results:</i> 5-HT<sub>1A</sub> density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20. <i>Conclusion: </i>Higher BA36 5-HT<sub>1A</sub> density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT<sub>1A</sub> antagonist adjuvant may improve treatment of depression in dementia.
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