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Träfflista för sökning "WFRF:(Lane Athene) srt2:(2016)"

Sökning: WFRF:(Lane Athene) > (2016)

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1.
  • Walsh, Eleanor I, et al. (författare)
  • Characteristics of men responding to an invitation to undergo testing for prostate cancer as part of a randomised trial.
  • 2016
  • Ingår i: Trials. - 1745-6215 .- 1745-6215. ; 17:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Sociodemographic characteristics are associated with participating in cancer screening and trials. We compared the characteristics of those responding with those not responding to a single invitation for prostate-specific antigen (PSA) testing for prostate cancer as part of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP).METHODS: Age, rurality and deprivation among 197,763 men from 271 cluster-randomised primary care centres in the UK were compared between those responding (n = 90,300) and those not responding (n = 100,953) to a prostate cancer testing invitation.RESULTS: There was little difference in age between responders and nonresponders. Responders were slightly more likely to come from urban rather than rural areas and were slightly less deprived than those who did not respond.CONCLUSION: These data indicate similarities in age and only minor differences in deprivation and urban location between responders and nonresponders. These differences were smaller, but in the same direction as those observed in other screening trials.TRIAL REGISTRATION: ISRCTN92187251 . Registered on 29 November 2004.
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2.
  • Simpkin, Andrew J., et al. (författare)
  • Prostate-specific antigen patterns in US and European populations : comparison of six diverse cohorts
  • 2016
  • Ingår i: BJU International. - 1464-4096 .- 1464-410X. ; 118:6, s. 911-918
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To determine whether there are differences in prostate-specific antigen (PSA) levels at diagnosis or changes in PSA levels between US and European populations of men with and without prostate cancer (PCa).SUBJECTS AND METHODS: We analysed repeated measures of PSA from six clinically and geographically diverse cohorts of men: two cohorts with PSA-detected PCa, two cohorts with clinically detected PCa and two cohorts without PCa. Using multilevel models, average PSA at diagnosis and PSA change over time were compared among study populations.RESULTS: The annual percentage PSA change of 4-5% was similar between men without cancer and men with PSA-detected cancer. PSA at diagnosis was 1.7 ng/mL lower in a US cohort of men with PSA-detected PCa (95% confidence interval 1.3-2.0 ng/mL), compared with a UK cohort of men with PSA-detected PCa, but there was no evidence of a different rate of PSA change between these populations.CONCLUSION: We found that PSA changes over time are similar in UK and US men diagnosed through PSA testing and even in men without PCa. Further development of PSA models to monitor men on active surveillance should be undertaken in order to take advantage of these similarities. We found no evidence that guidelines for using PSA to monitor men cannot be passed between US and European studies.
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