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Träfflista för sökning "WFRF:(Nosten F) srt2:(2005-2009)"

Sökning: WFRF:(Nosten F) > (2005-2009)

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1.
  • Lindegårdh, N, et al. (författare)
  • Piperaquine, new findings
  • 2005
  • Ingår i: International Congress for Tropical medicine and Malaria. - Marseille.
  • Konferensbidrag (refereegranskat)
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2.
  • Tärning, Joel, 1977, et al. (författare)
  • Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.
  • 2008
  • Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804. ; 52:3, s. 1052-61
  • Tidskriftsartikel (refereegranskat)abstract
    • The population pharmacokinetics of piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria treated with two different dosage regimens of dihydroartemisinin-piperaquine were characterized. Piperaquine pharmacokinetics in 98 Burmese and Karen patients aged 3 to 55 years were described by a two-compartment disposition model with first-order absorption and interindividual random variability on all parameters and were similar with the three- and four-dose regimens. Children had a lower body weightnormalized oral clearance than adults, resulting in longer terminal elimination half-lives and higher total exposure to piperaquine (area under the concentration-time curve from 0 to 63 days [AUCday 0–63]). However, children had lower plasma concentrations in the therapeutically relevant posttreatment prophylactic period (AUCday 3–20) because of smaller body weight-normalized central volumes of distribution and shorter distribution half-lives. Our data lend further support to a simplified once-daily treatment regimen to improve treatment adherence and efficacy and indicate that weight-adjusted piperaquine doses in children may need to be higher than in adults.
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