↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Andersen Mikkel R.) ;srt2:(2017)"

Sökning: WFRF:(Andersen Mikkel R.) > (2017)

Resultat 1-3 av 3

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Ezzati, M, et al. (författare) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults 2017 Ingår i: Lancet (London, England). - : Elsevier. - 1474-547X .- 0140-6736. ; 390:10113, s. 2627-2642 Tidskriftsartikel (refereegranskat)
2.	Zhou, B, et al. (författare) Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants 2017 Ingår i: Lancet (London, England). - 1474-547X .- 0140-6736. ; 389:10064, s. 37-55 Tidskriftsartikel (refereegranskat)
3.	Pingel, Jessica, et al. (författare) Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of the fibrilar and non-fibrilar structures 2017 Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1 Tidskriftsartikel (refereegranskat)abstract Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular BoNT/A injections (6 UI = 60 pg) on muscle tissue. The gait pattern of the rats was significantly affected 3 weeks after BoNT/A injection. The ankle joint rotated externally, the rats became flat footed, and the stride length decreased after BoNT/A injection. Additionally, there was clear evidence of microstructural changes on the tissue level by as evidenced by 3D imaging of the muscles by Synchrotron Radiation X-ray Tomographic Microscopy (SRXTM). Both the fibrillar and the non-fibrillar tissues were affected. The volume fraction of fibrillary tissue was reduced significantly and the non-fibrillar tissue increased. This was accompanied by a loss of the linear structure of the muscle tissue. Furthermore, gene expression analysis showed a significant upregulation of COL1A1, MMP-2, TGF-b1, IL-6, MHCIIA and MHCIIx in the BoNT/A injected leg, while MHVIIB was significantly downregulated. In conclusion: The present study reveals that high dose intramuscular BoNT/A injections cause microstructural damage of the muscle tissue, which contributes to impaired gait.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-3 av 3

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Zhou, B. (2); Liu, J. (2); Andersen, LB (2); Bruno, G. (2); Peters, A (2); Evans, A. (2); visa fler...; Kujala, UM (2); Zeng, Y. (2); Kim, J. (2); Overvad, K (2); Tjonneland, A (2); Kaur, P. (2); Diaz, A. (2); Song, Y. (2); Bilano, V (2); Brenner, H (2); Djalalinia, S (2); Farzadfar, F (2); Giampaoli, S (2); Ikeda, N (2); Islam, M (2); Jonas, JB (2); Khang, YH (2); Lotufo, PA (2); Malekzadeh, R (2); Mohammadifard, N (2); Nagel, G (2); Ostojic, SM (2); Panda-Jonas, S (2); Pourshams, A (2); Santos, IS (2); Sarrafzadegan, N (2); Schutte, AE (2); Sepanlou, SG (2); Shibuya, K (2); Silva, DAS (2); Sobngwi, E (2); Topor-Madry, R (2); Wojtyniak, B (2); Boeing, H. (2); Kaaks, R. (2); Riboli, E. (2); Henriques, A. (2); Santos, R. (2); Lu, Y (2); Lee, J. (2); Nakamura, H (2); Chen, ZM (2); Fischer, K. (2); Tang, X. (2); visa färre...

Lärosäte: Lunds universitet (3); Göteborgs universitet (2); Umeå universitet (2); Uppsala universitet (2); Karolinska Institutet (2); Högskolan Dalarna (2); visa fler...; Högskolan i Skövde (1); visa färre...

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3); Naturvetenskap (1)

År: 2017 (3)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy