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- Lind, Lars, et al.
(författare)
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Left ventricular hypertrophy in hypertension is associated with the insulin resistance metabolic syndrome
- 1995
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Ingår i: Journal of Hypertension. - 0263-6352 .- 1473-5598. ; 13:4, s. 433-438
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To investigate whether left ventricular hypertrophy is associated with the insulin resistance syndrome. METHODS: Fifty patients with untreated hypertension were evaluated by recording office blood pressure during regular antihypertensive treatment and 24-h ambulatory blood pressure and office blood pressure after 4-6 weeks on placebo, echocardiography with M-mode measurements of left ventricular wall thickness and pulsed-wave Doppler measurements of mitral flow in diastole and the hyperinsulinaemic euglycaemic clamp, for determination of insulin sensitivity. RESULTS: The left ventricular wall thickness was found to be significantly related to blood pressure [r = 0.44, P < 0.004 for 24-h ambulatory systolic blood pressure (SBP)], fasting insulin level (r = 0.32, P < 0.03) and haematocrit level (r = 0.37, P < 0.009) and inversely related to insulin sensitivity (r = -0.59, P < 0.0001). Multiple regression analysis with these relationships together with confounding factors age, sex, body mass index and waist: hip ratio as independent variables showed insulin sensitivity to be the only significant variable, explaining 43% of the variation in left ventricular wall thickness, whereas 24-h ambulatory SBP explained a further 7%. Left ventricular diastolic filling, as evaluated by the mitral Doppler early: atrial ratio, was significantly correlated with insulin sensitivity (r = 0.42, P < 0.003) and inversely related to blood pressure (r = -0.41, P < 0.02 for 24-h ambulatory SBP), left ventricular wall thickness (r = -0.34, P < 0.02) and serum fibrinogen level (r = -0.63, P < 0.0001). However, multiple regression analysis showed that insulin sensitivity was more closely related to diastolic filling than to blood pressure or left ventricular wall thickness. CONCLUSION: The present study showed left ventricular wall thickness to be closely associated with insulin resistance. Because diastolic dysfunction of the left ventricle was also related to a decreased insulin sensitivity, these findings suggest that left ventricular hypertrophy and diastolic dysfunction are associated with the insulin resistance metabolic syndrome.
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- Robertsson, A M, et al.
(författare)
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Pleistocene stratigraphy in the Dellen region, central Sweden
- 1997
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Ingår i: Boreas. - : Wiley. - 0300-9483 .- 1502-3885. ; 26, s. 237-260
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Tidskriftsartikel (refereegranskat)abstract
- The Pleistocene stratigraphy in the Dellen region, central Sweden was studied using field observations made during mapping of Quaternary deposits and fabric analyses in excavated sections. The lithostratigraphy was also studied by seismic refraction measurements, analyses of grain-size distribution and organic carbon content. Biostratigraphical methods applied were pollen and diatom analyses. A general outline of the Pleistocene stratigraphy in the area is presented. Three different till beds are identified, the lowermost suggested to have been deposited during the Saalian glaciation and the other two during the Weichselian glaciation. According to the interpretation of the stratigraphy, it is questioned whether the first Weichselian ice sheer did in fact reach the Dellen area. A clayey sediment sequence at Norra Sannas accumulated during an interglacial, probably the Eemian. Most of the interglacial vegetation succession is reflected in the identified pollen flora. An initial phase with a light-demanding forest of Betula and Pinus was followed by immigration of Alnus, Picea and scattered occurrences of Corylus. A freshwater diatom flora was identified dominated by plankton taxa, e.g. Aulacoseira italica, A. distans and Cyclotella spp. In the lower part of the sequence a brackish-marine flora was registered, representing accumulation in a bay of the Eemian Sea. Fine-grained sediments at the Sundson and Vastansjo sites are interpreted as rebedded Eemiar. sediments according to the pollen flora. An (Early Weichselian) interstadial age is suggested ibr sediments found at Bjuraker. Dating by the C-14- and OSL methods was carried out on the interglacial and interstadial sediments, respectively. The ages range from approximately 19 000 to 92 000 BP. Correlation of interglacial vegetation history with central Finland and other areas is discussed.
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