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1.	Hovland, Anders, et al. (author) The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis 2015 In: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 241:2, s. 480-494 Research review (peer-reviewed)abstract Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier research focus on adaptive immunity has gradually switched towards the role of innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between them, may be of particular interest both with respect to pathogenesis and as therapeutic targets in atherosclerosis. Animal studies indicate that inhibition of C3a and C5a reduces atherosclerosis. In humans modified LDL-cholesterol activate complement and TLRs leading to downstream inflammation, and histopathological studies indicate that the innate immune system is present in atherosclerotic lesions. Moreover, clinical studies have demonstrated that both complement and TLRs are upregulated in atherosclerotic diseases, although interventional trials have this far been disappointing. However, based on recent research showing an intimate interplay between complement and TLRs we propose a model in which combined inhibition of both complement and TLRs may represent a potent anti-inflammatory therapeutic approach to reduce atherosclerosis. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
2.	Wallentin, Lars, et al. (author) Activated Leukocyte Cell Adhesion Molecule (ALCAM) And Outcomes In Acute Coronary Syndromes : A Plato Biomarker Substudy 2015 In: Journal of the American College of Cardiology. - Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden. Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.. - 0735-1097 .- 1558-3597. ; 65:10, s. A231-A231 Journal article (other academic/artistic)

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Type of publication: journal article (1); research review (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Aukrust, Pal (2); Siegbahn, Agneta (1); Garred, Peter (1); Ueland, Thor (1); Wallentin, Lars (1); Bertilsson, Maria (1); show more...; Husted, Steen (1); Jonasson, Lena (1); Himmelmann, Anders (1); Michelsen, Annika E. (1); Kontny, Frederic (1); Hovland, Anders (1); Mollnes, Tom E. (1); Becker, Richard (1); Storey, Robert (1); Espevik, Terje (1); Budaj, Andrzej (1); Cornel, Jan (1); Yndestad, Arne (1); Lappegard, Knut T. (1); show less...

University: Uppsala University (1); Linköping University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2015 (2)Undo refine

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