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Polymorphisms at ne...
Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population
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Tai, E. Shyong (author)
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Sim, Xue Ling (author)
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Ong, Twee Hee (author)
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Wong, Tien Yin (author)
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Saw, Seang Mei (author)
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Aung, Tin (author)
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Kathiresan, Sekar (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Ordovas, Jose M. (author)
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Tan, Jonathan T. (author)
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Seielstad, Mark (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Journal of Lipid Research. - 1539-7262. ; 50:3, s. 514-520
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- We conducted a cross-sectional study of Malay articipants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.-Tai, E. S., X. L. Sim, T. H. Ong, T. Y. Wong, S. M. Saw, T. Aung, S. Kathiresan, M. Orho-Melander, J. M. Ordovas, J. T. Tan, and M. Seielstad. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J. Lipid Res. 2009. 50: 514-520.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- genetics
- ethnic group
- coronary heart disease
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tai, E. Shyong
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Sim, Xue Ling
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Ong, Twee Hee
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Wong, Tien Yin
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Saw, Seang Mei
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Aung, Tin
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show more...
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Kathiresan, Seka ...
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Orho-Melander, M ...
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Ordovas, Jose M.
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Tan, Jonathan T.
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Seielstad, Mark
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Lipid ...
- By the university
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Lund University