| 1. |
- Schweinsberg, Martin, et al.
(författare)
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Same data, different conclusions : Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
- 2021
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Ingår i: Organizational Behavior and Human Decision Processes. - : Elsevier BV. - 0749-5978 .- 1095-9920. ; 165, s. 228-249
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Tidskriftsartikel (refereegranskat)abstract
- In this crowdsourced initiative, independent analysts used the same dataset to test two hypotheses regarding the effects of scientists' gender and professional status on verbosity during group meetings. Not only the analytic approach but also the operationalizations of key variables were left unconstrained and up to individual analysts. For instance, analysts could choose to operationalize status as job title, institutional ranking, citation counts, or some combination. To maximize transparency regarding the process by which analytic choices are made, the analysts used a platform we developed called DataExplained to justify both preferred and rejected analytic paths in real time. Analyses lacking sufficient detail, reproducible code, or with statistical errors were excluded, resulting in 29 analyses in the final sample. Researchers reported radically different analyses and dispersed empirical outcomes, in a number of cases obtaining significant effects in opposite directions for the same research question. A Boba multiverse analysis demonstrates that decisions about how to operationalize variables explain variability in outcomes above and beyond statistical choices (e.g., covariates). Subjective researcher decisions play a critical role in driving the reported empirical results, underscoring the need for open data, systematic robustness checks, and transparency regarding both analytic paths taken and not taken. Implications for orga-nizations and leaders, whose decision making relies in part on scientific findings, consulting reports, and internal analyses by data scientists, are discussed.
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| 2. |
- Bauer, Ann Z., et al.
(författare)
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Paracetamol use during pregnancy - a call for precautionary action
- 2021
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Ingår i: Nature Reviews Endocrinology. - : Springer Nature. - 1759-5029 .- 1759-5037. ; 17, s. 757-766
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Tidskriftsartikel (refereegranskat)abstract
- Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe. A growing body of research suggests that prenatal exposure to paracetamol (APAP) might alter development and increase the risk of some reproductive, urogenital and neurodevelopmental disorders. This Consensus Statement calls for precautionary action, including a focused research effort, increasing awareness among health professionals and pregnant women and, whenever possible, minimizing use.
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| 3. |
- Bauer, Thomas, et al.
(författare)
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Cross-domain Modelling of Verification and Validation Workflows in the Large Scale European Research Project VALU3S
- 2021
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Ingår i: Lecture Notes in Computer Science. - Cham : Springer. ; , s. 386-382
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Konferensbidrag (refereegranskat)abstract
- The complexity of systems continues to increase rapidly, especially due to the multi-level integration of subsystems from different domains into cyber-physical systems. This results in special challenges for the efficient verification and validation (V&V) of these systems with regard to their requirements and properties. In order to tackle the new challenges and improve the quality assurance processes, the V&V workflows have to be documented and analyzed. In this paper, a novel approach for the workflow modelling of V&V activities is presented. The generic approach is tailorable to different industrial domains and their specific constraints, V&V methods, and toolchains. The outcomes comprise a dedicated modelling notation (VVML) and tool-support using the modelling framework Enterprise Architect for the efficient documentation and implementation of workflows in the use cases. The solution enables the design of re-usable workflow assets such as V&V activities and artifacts that are exchanged between workflows. This work is part of the large scale European research project VALU3S that deals with the improvement and evaluation of V&V processes in different technical domains, focusing on safety, cybersecurity, and privacy properties.
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| 4. |
- Ebrahimi-Fakhari, Darius, et al.
(författare)
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Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia
- 2020
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Ingår i: Brain. - OXFORD ENGLAND : Oxford University Press (OUP). - 0006-8950 .- 1460-2156. ; 143:10, s. 2929-2944
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Tidskriftsartikel (refereegranskat)abstract
- Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of childhood-onset and complex hereditary spastic paraplegia: SPG47 (AP4B1), SPG50 (AP4M1), SPG51 (AP4E1) and SPG52 (AP4S1). Here, we report a detailed cross-sectional analysis of clinical, imaging and molecular data of 156 patients from 101 families. Enrolled patients were of diverse ethnic backgrounds and covered a wide age range (1.0-49.3 years). While the mean age at symptom onset was 0.8 +/- 0.6 years [standard deviation (SD), range 0.2-5.0], the mean age at diagnosis was 10.2 +/- 8.5 years (SD, range 0.1-46.3). We define a set of core features: early-onset developmental delay with delayed motor milestones and significant speech delay (50% non-verbal); intellectual disability in the moderate to severe range; mild hypotonia in infancy followed by spastic diplegia (mean age: 8.4 +/- 5.1 years, SD) and later tetraplegia (mean age: 16.1 +/- 9.8 years, SD); postnatal microcephaly (83%); foot deformities (69%); and epilepsy (66%) that is intractable in a subset. At last follow-up, 36% ambulated with assistance (mean age: 8.9 +/- 6.4 years, SD) and 54% were wheelchair-dependent (mean age: 13.4 +/- 9.8 years, SD). Episodes of stereotypic laughing, possibly consistent with a pseudobulbar affect, were found in 56% of patients. Key features on neuroimaging include a thin corpus callosum (90%), ventriculomegaly (65%) often with colpocephaly, and periventricular white-matter signal abnormalities (68%). Iron deposition and polymicrogyria were found in a subset of patients. AP4B1-associated SPG47 and AP4M1-associated SPG50 accounted for the majority of cases. About two-thirds of patients were born to consanguineous parents, and 82% carried homozygous variants. Over 70 unique variants were present, the majority of which are frameshift or nonsense mutations. To track disease progression across the age spectrum, we defined the relationship between disease severity as measured by several rating scales and disease duration. We found that the presence of epilepsy, which manifested before the age of 3 years in the majority of patients, was associated with worse motor outcomes. Exploring genotype-phenotype correlations, we found that disease severity and major phenotypes were equally distributed among the four subtypes, establishing that SPG47, SPG50, SPG51 and SPG52 share a common phenotype, an 'AP-4 deficiency syndrome'. By delineating the core clinical, imaging, and molecular features of AP-4-associated hereditary spastic paraplegia across the age spectrum our results will facilitate early diagnosis, enable counselling and anticipatory guidance of affected families and help define endpoints for future interventional trials.
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| 5. |
- Abolfathi, Bela, et al.
(författare)
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The LSST DESC DC2 Simulated Sky Survey
- 2021
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Ingår i: Astrophysical Journal Supplement Series. - : American Astronomical Society. - 0067-0049 .- 1538-4365. ; 253:31
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Tidskriftsartikel (refereegranskat)abstract
- We describe the simulated sky survey underlying the second data challenge (DC2) carried out in preparation for analysis of the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) by the LSST Dark Energy Science Collaboration (LSST DESC). Significant connections across multiple science domains will be a hallmark of LSST; the DC2 program represents a unique modeling effort that stresses this interconnectivity in a way that has not been attempted before. This effort encompasses a full end-to-end approach: starting from a large N-body simulation, through setting up LSST-like observations including realistic cadences, through image simulations, and finally processing with Rubin's LSST Science Pipelines. This last step ensures that we generate data products resembling those to be delivered by the Rubin Observatory as closely as is currently possible. The simulated DC2 sky survey covers six optical bands in a wide-fast-deep area of approximately 300 deg2, as well as a deep drilling field of approximately 1 deg2. We simulate 5 yr of the planned 10 yr survey. The DC2 sky survey has multiple purposes. First, the LSST DESC working groups can use the data set to develop a range of DESC analysis pipelines to prepare for the advent of actual data. Second, it serves as a realistic test bed for the image processing software under development for LSST by the Rubin Observatory. In particular, simulated data provide a controlled way to investigate certain image-level systematic effects. Finally, the DC2 sky survey enables the exploration of new scientific ideas in both static and time domain cosmology.
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| 6. |
- Alder-Rangel, Alene, et al.
(författare)
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The Third International Symposium on Fungal Stress – ISFUS
- 2020
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Ingår i: Fungal Biology. - : Elsevier BV. - 1878-6146. ; 124:5, s. 235-252
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Tidskriftsartikel (refereegranskat)abstract
- Stress is a normal part of life for fungi, which can survive in environments considered inhospitable or hostile for other organisms. Due to the ability of fungi to respond to, survive in, and transform the environment, even under severe stresses, many researchers are exploring the mechanisms that enable fungi to adapt to stress. The International Symposium on Fungal Stress (ISFUS) brings together leading scientists from around the world who research fungal stress. This article discusses presentations given at the third ISFUS, held in São José dos Campos, São Paulo, Brazil in 2019, thereby summarizing the state-of-the-art knowledge on fungal stress, a field that includes microbiology, agriculture, ecology, biotechnology, medicine, and astrobiology.
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| 7. |
- Bauer, Bjørn, et al.
(författare)
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Circular plastics in electrical and electronic equipment
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report explores what the Nordic countries can do to promote the use of recyclable plastic components in electrical and electronic products, with particular focus on minimising their hazardous chemical component. The report provides an overview of the hazardous additives currently used in the plastic components of EEE, drawing on information available from legislation and supporting studies, research and academia, NGOs and market actors. The results presented here build upon input collected though a literature study, a policy analysis of EU and Nordic legislation and initiatives, interviews with experts across the value chain and an expert workshop. Together these inputs were used to assess and qualify possible future actions in the Nordic countries to minimise hazardous chemicals in plastic components of EEE.
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| 8. |
- Bauer, Florian, et al.
(författare)
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Navigating challenging contexts : Costs and benefits of codified acquisition experience
- 2021
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Ingår i: Long range planning. - : Elsevier BV. - 0024-6301 .- 1873-1872. ; 54:6
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Tidskriftsartikel (refereegranskat)abstract
- Despite its intuitive appeal, acquisition experience has not shown a clear benefit to acquirers, and we argue the applicability of acquisition experience depends on goals and context. Using survey data, we consider the effects of applying codified experience for two common acquisition goals involving knowledge transfer and market expansion. Our findings reveal a 'double-edged sword' effect, where on one hand, codification mitigates negative effects of industry rivalry on knowledge transfer. However, on the other hand, codification amplifies negative effects of industry rivalry on market expansion and internal turmoil on knowledge transfer. Beyond demonstrating the importance of goals and context contingencies for determining acquisition experience effect, our results reconcile conflicting research findings to identify when codified experience is beneficial in acquisitions.
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| 9. |
- Bauer, Ingrid, et al.
(författare)
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White paper on Next Generation Metrics
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- We - the writers - of this paper summarise a methodological debate amongst experts from our Members on ´traditional´ and ´next generation metrics´ for science, education and innovation in the light of the developments and expectations towards greater ´openness´ to realise long-term ecological, economic and social sustainability and benefit to citizens and to the world. A broad range of indicators from various sources were discussed in terms of feasibility in different contexts, as well as their suitability to serve diverse purposes. Rather than presenting a formal position on behalf of CESAER, we present our synthesis of this debate. In chapter one, we provide the definitions, describe the methodology used and set the scope of this paper, thus setting the scene for the following chapters. In chapter two, we report on our findings on metrics dealing with (open) science. Ever since E. Garfield’s Journal Impact Factor (JIF) came into use in the mid-70s, and certainly with the h-index proposed by the physicist J. E. Hirsch in 2005, the rise of quantitative metrics in the assessment of research has seemed to be unstoppable - up to the use of ´views´, ´likes´ and ´tweets´. While in times of accountability and competing for visibility and funds, it is only reasonable to focus on the measurability and comparability of metrics as efficient means to display performance, the limitations of doing so are obvious. As a result, in the past years, a countermovement criticising this practice and questioning the validity of the metrics and reliability of the data used has become stronger. Moreover, there are strong (political) expectations to make science more open. Metrics for (open) education and training are the topic of chapter three. In many (global) rankings of higher education institutions, the indicators used reflect the model of traditional, established, wealthy and largely English-speaking research universities (Hazelkorn, 2015). They are, therefore, ill-suited to truly give an idea about the quality or the performance of higher education more broadly, and they are limited in helping universities to set priorities. They do, however, reveal that there is still a lack of meaningful internationally comparable information on these matters. By covering (open) innovation in chapter four, we complete the discussion of the mission of our Members. Open innovation promotes approaches that boost disruptive innovation rather than incremental, stimulate inventions produced by outsiders and founders in start-ups, and is based on a view on the world of widely distributed knowledge. We synthesised our findings on the confrontation between ´traditional´ and ´next generation metrics´ and present ten each for science, education and innovation for use mainly within our Members and to monitor the desired progress over time (see annexe I). While this might be interpreted as sufficient responsiveness to external expectations on our behalf, we instead advanced further and in chapter five suggest that universities strive towards ´progressive metrics´ and highlight the need to acknowledge knowledge as a common good, promote a culture of quality, risk-taking and trust and measure the contribution to sustainability. That is why we conclude this paper with ideas for progressive indicators in annexe II, outlining an agenda for future work to stay at the forefront of science, education and innovation; to benchmark against like-minded institutions; and to pursue institutional development paths; and - ultimately - to optimise our contributions to society and the world.
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| 10. |
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