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Risk factors for pe...
Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis
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- Droppa, Michal (author)
- Univ Hosp Tubingen, Germany
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- Rudolph, Tanja K. (author)
- Cologne Univ, Germany; Heart and Diabet Ctr NRW, Germany
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- Baan, Jan (author)
- Univ Amsterdam, Netherlands
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- Nielsen, Niels Erik, 1956- (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Baumgartner, Helmut (author)
- Univ Hosp Muenster, Germany
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- Vendrik, Jeroen (author)
- Univ Amsterdam, Netherlands
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- Froehlich, Maren (author)
- Inst Pharmacol and Prevent Med, Germany
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- Borst, Oliver (author)
- Univ Hosp Tubingen, Germany
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- Woehrle, Jochen (author)
- Univ Ulm, Germany
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- Gawaz, Meinrad (author)
- Univ Hosp Tubingen, Germany
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- Potratz, Paul (author)
- Univ Hosp Tubingen, Germany
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- Hack, Luis P. (author)
- Univ Hosp Tubingen, Germany
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- Mauri, Victor (author)
- Cologne Univ, Germany
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- Baranowski, Jacek (author)
- Region Östergötland, Kardiologiska kliniken US
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- Bramlage, Peter (author)
- Inst Pharmacol and Prevent Med, Germany
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- Kurucova, Jana (author)
- Edwards Lifesci, Czech Republic
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- Thoenes, Martin (author)
- Edwards Lifesci, Switzerland
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- Rottbauer, Wolfgang (author)
- Univ Ulm, Germany
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- Geisler, Tobias (author)
- Univ Hosp Tubingen, Germany
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(creator_code:org_t)
- 2020-06-26
- 2020
- English.
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In: Heart and Vessels. - : Springer. - 0910-8327 .- 1615-2573. ; 35, s. 1735-1745
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Permanent pacemaker implantation (PPI) is a widely recognized complication associated with TAVI (incidence up to 20%). Smaller registries have identified several variables associated with PPI. The objective was to validate patient- and transcatheter aortic valve implantation (TAVI)-related procedural variables associated with PPI. We performed a retrospective analysis of patients from six European centers undergoing TAVI with the Edwards SAPIEN 3 prosthesis. Baseline variables and pre-procedural ECG characteristics and CT-scans were taken into account. Data for 1745 patients were collected; 191 (10.9%) required PPI after TAVI. The baseline variables pulmonary hypertension (OR 1.64; 95% CI 1.01-2.59), QRS duration > 117 ms (OR 2.58; 95% CI 1.73-3.84), right bundle branch block (RBBB; OR 5.14; 95% CI 3.39-7.72), left anterior hemi block (OR 1.92; 95% CI 1.19-3.02) and first-degree atrioventricular block (AVB, OR 1.63; 95%CI 1.05-2.46) were significantly associated with PPI. RBBB (OR 8.11; 95% CI 3.19-21.86) and first-degree AVB (OR 2.39; 95% CI 1.18-4.66) remained significantly associated in a multivariate analysis. Procedure-related variables included access site (TF; OR 1.97; 95% CI 1.07-4.05), implanted valve size (29 mm; OR 1.88; 95% CI 1.35-2.59), mean TAVI valve implantation depth below the annulus > 30% (OR 3.75; 95% CI 2.01-6.98). Patients receiving PPI had longer ICU stays and later discharges. Acute kidney injury stage 2/3 was more common in patients with PPI until discharge (15.2 vs. 3.1%;p = 0.007), but was not statistically significant thereafter. Further differences in outcomes at 30 days did not reach significance. The data will aid pre- and post-procedural patient management and prevent adverse long-term outcomes. Clinical Trial: NCT03497611.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Aortic stenosis; Transcatheter aortic valve implantation; Pacemaker
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Droppa, Michal
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Rudolph, Tanja K ...
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Baan, Jan
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Nielsen, Niels E ...
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Baumgartner, Hel ...
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Vendrik, Jeroen
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Froehlich, Maren
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Borst, Oliver
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Woehrle, Jochen
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Gawaz, Meinrad
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Potratz, Paul
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Hack, Luis P.
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Mauri, Victor
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Baranowski, Jace ...
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Bramlage, Peter
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Kurucova, Jana
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Thoenes, Martin
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Rottbauer, Wolfg ...
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Geisler, Tobias
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Heart and Vessel ...
- By the university
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Linköping University