| 1. |
- Kasliwal, Mansi M., et al.
(författare)
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Kilonova Luminosity Function Constraints Based on Zwicky Transient Facility Searches for 13 Neutron Star Merger Triggers during O3
- 2020
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 905:2
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Tidskriftsartikel (refereegranskat)abstract
- We present a systematic search for optical counterparts to 13 gravitational wave (GW) triggers involving at least one neutron star during LIGO/Virgo's third observing run (O3). We searched binary neutron star (BNS) and neutron star black hole (NSBH) merger localizations with the Zwicky Transient Facility (ZTF) and undertook follow-up with the Global Relay of Observatories Watching Transients Happen (GROWTH) collaboration. The GW triggers had a median localization area of 4480 deg(2), a median distance of 267 Mpc, and false-alarm rates ranging from 1.5 to 10(-25) yr(-1). The ZTF coverage in the g and r bands had a median enclosed probability of 39%, median depth of 20.8 mag, and median time lag between merger and the start of observations of 1.5 hr. The O3 follow-up by the GROWTH team comprised 340 UltraViolet/Optical/InfraRed (UVOIR) photometric points, 64 OIR spectra, and three radio images using 17 different telescopes. We find no promising kilonovae (radioactivity-powered counterparts), and we show how to convert the upper limits to constrain the underlying kilonova luminosity function. Initially, we assume that all GW triggers are bona fide astrophysical events regardless of false-alarm rate and that kilonovae accompanying BNS and NSBH mergers are drawn from a common population; later, we relax these assumptions. Assuming that all kilonovae are at least as luminous as the discovery magnitude of GW170817 (-16.1 mag), we calculate that our joint probability of detecting zero kilonovae is only 4.2%. If we assume that all kilonovae are brighter than -16.6 mag (the extrapolated peak magnitude of GW170817) and fade at a rate of 1 mag day(-1) (similar to GW170817), the joint probability of zero detections is 7%. If we separate the NSBH and BNS populations based on the online classifications, the joint probability of zero detections, assuming all kilonovae are brighter than -16.6 mag, is 9.7% for NSBH and 7.9% for BNS mergers. Moreover, no more than <57% (<89%) of putative kilonovae could be brighter than -16.6 mag assuming flat evolution (fading by 1 mag day(-1)) at the 90% confidence level. If we further take into account the online terrestrial probability for each GW trigger, we find that no more than <68% of putative kilonovae could be brighter than -16.6 mag. Comparing to model grids, we find that some kilonovae must have M-ej M, X-lan > 10(-4), or > 30 degrees to be consistent with our limits. We look forward to searches in the fourth GW observing run; even 17 neutron star mergers with only 50% coverage to a depth of -16 mag would constrain the maximum fraction of bright kilonovae to <25%.
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| 3. |
- Svedenmark, Sara, 1971-, et al.
(författare)
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Old Wine in a New Bottle? – Interpreting Gender Mainstreaming in a Municipal Reorganisation
- 2022
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Ingår i: Scandinavian Journal of Public Administration. - Göteborg : University of Gothenburg. - 2001-7405 .- 2001-7413. ; :4, s. 73-90
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Tidskriftsartikel (refereegranskat)abstract
- Gender mainstreaming (GM) has been on the agenda of organisations at various levels in Sweden and worldwide since the 1990s. Research has shown that GM is difficult to apply and has yet to be clearly defined, and additionally that organisations are uncertain about how to implement it. Research also suggests that the dominance of the new public management (NPM) approach within organisations has made GM work more challenging. In this article, we examine GM in a medium-sized Swedish municipality that is reorganising itself to become gender mainstreamed while introducing trust-based governance (TBG). This municipality provides a unique opportunity to study how GM is constructed in a municipality at the intersection of NPM and TBG. Applying a critical perspective, this article analyses documents from reorganisation based on Bacchi’s (2009) policy analysis. The results demonstrate that GM is mainly translated into TBG-inspired practices and that efficiency becomes an overarching concept that entangles GM, TBG and NPM. GM becomes part of cultural change together with TBG, while NPM maintains its dominance in the structural change of the organisation.
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| 4. |
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| 5. |
- Borgenvik, Anna, 1987-, et al.
(författare)
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Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
- 2022
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Ingår i: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 82:24, s. 4586-4603
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Tidskriftsartikel (refereegranskat)abstract
- Relapse is the leading cause of death in patients with medulloblas-toma, the most common malignant pediatric brain tumor. A better understanding of the mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification. In paired primary-recurrent patient samples, SOX9-positive cells accumulated in medulloblastoma relapses. SOX9 expression anti-correlated with MYC expression in murine and human medulloblastoma cells. However, SOX9-positive cells were plastic and could give rise to a MYC high state. To follow relapse at the single-cell level, an inducible dual Tet model of medulloblastoma was developed, in which MYC expression was redirected in vivo from treatment-sensitive bulk cells to dormant SOX9-positive cells using doxycycline treatment. SOX9 was essential for relapse initiation and depended on suppression of MYC activity to promote therapy resistance, epithelial-mesenchymal transition, and immune escape. p53 and DNA repair pathways were downregulated in recurrent tumors, whereas MGMT was upregulated. Recurrent tumor cells were found to be sensitive to treatment with an MGMT inhibitor and doxorubicin. These findings suggest that recurrence-specific targeting coupled with DNA repair inhibition comprises a potential therapeutic strategy in patients affected by medulloblastoma relapse.Significance: SOX9 facilitates therapy escape and recurrence in medulloblastoma via temporal inhibition of MYC/MYCN genes, revealing a strategy to specifically target SOX9-positive cells to prevent tumor relapse.
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| 6. |
- Kjölstad, Henrik, 1980-
(författare)
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A European Declaration of Fascism? : En analys av Anders Behring Breiviks manifest 2083
- 2020
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The terror attacks in Oslo, July 22, 2011, executed by Anders Behring Breivik, showed the deadliest outbreak of political violence in Norway since World War II. After the subsequent apprehension of Breivik, discussions about his ideological positioning soon emerged. While Breivik was initially described as an Islamophobic, right wing-extremist, a few expert witnesses and scholars labeled him and his manifesto 2083: A Declaration of European Independence as fascist. Some analysts disagreed with such a categorization and argued that Breivik's views had little to do with fascism. Other commentators and academics partly agreed with the fascist label but added that Breivik's ideology differed from classical fascism in several ways. The aim of this research is to examine whether the manifesto 2083 can be classified as fascist according to various established definitions and ideal types of fascism. In particular, this research draws on the theories, definitions, and ideal types of fascism of established scholars Roger Griffin, Stanley G. Payne, and Emilio Gentile to inform a content analysis of 2083.The study's relevance concerns the ideology of and behind certain violent political activism, and if fascism is undergoing a transformation which urges updates of established definitions of the phenomenon. 2083 is treated as an outlier or deviant case of fascism.This research finds that 2083 does fulfill several fascist criteria, and even concepts central to the ideal types. However, the results are at times ambiguous and open to further interpretation. Fascist concepts such as national rebirth, a glorification of violence, and religiously tinged activism are expressed in the manifesto, but crucial details regarding them remain unexplored or unspecified. 2083's violent strategies for achieving desired societal change have striking similarities with certain contemporary race radicalism; while descriptions of societal condition and utopian goals share certain fascism characteristics, but also resemble late 19th Century German revolutionary conservatism or proto-fascism. Thus, one might rather see 2083 as hybrid form of different, already existing, fascist ideological traits rather than a “new” form of fascism.
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| 8. |
- Nyhlén, Sara, 1980-, et al.
(författare)
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Att studera lokalt beslutsfattande
- 2022. - 2
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Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144155937 ; , s. 87-90
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Olausson, Pär M., Docent, 1968-, et al.
(författare)
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Lokalt beslutsfattande - en introduktion
- 2022. - 2
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Ingår i: Lokalt beslutsfattande. - Lund : Studentlitteratur AB. - 9789144155937 ; , s. 13-24
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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