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Träfflista för sökning "WFRF:(Boomsma D) srt2:(2010-2014)"

Sökning: WFRF:(Boomsma D) > (2010-2014)

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Numrering	Referens	Omslagsbild	Hitta
1.	Dupuis, J, et al. (författare) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk 2010 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:2, s. 105-U32 Tidskriftsartikel (refereegranskat)
2.	Lee, SH, et al. (författare) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2013 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:9, s. 984- Tidskriftsartikel (refereegranskat)
3.	den Hoed, Marcel, et al. (författare) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders 2013 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:6, s. 621- Tidskriftsartikel (refereegranskat)
4.	Wood, AR, et al. (författare) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Tidskriftsartikel (refereegranskat)
5.	Palmer, Nicholette D, et al. (författare) A genome-wide association search for type 2 diabetes genes in African Americans. 2012 Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202- Tidskriftsartikel (refereegranskat)abstract African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
6.	Perry, JRB, et al. (författare) Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche 2014 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 514:7520, s. 92- Tidskriftsartikel (refereegranskat)
7.	Sabater-Lleal, M, et al. (författare) Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease 2013 Ingår i: Circulation. - 1524-4539. ; 128:12, s. 1310-1324 Tidskriftsartikel (refereegranskat)
8.	Thompson, Paul M., et al. (författare) The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data 2014 Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182 Tidskriftsartikel (refereegranskat)abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
9.	Wain, LV, et al. (författare) Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure 2011 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 1005-U122 Tidskriftsartikel (refereegranskat)
10.	Randall, JC, et al. (författare) Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits 2013 Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 9:6, s. e1003500- Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (44); konferensbidrag (2)

Typ av innehåll: refereegranskat (44); övrigt vetenskapligt/konstnärligt (2)

Författare/redaktör: Boomsma, Dorret I. (21); Boomsma, DI (20); Willemsen, Gonneke (20); Hottenga, JJ (18); van Duijn, Cornelia ... (18); Willemsen, G (17); visa fler...; Groop, Leif (17); Mangino, Massimo (17); Hofman, Albert (17); Martin, Nicholas G. (16); Stefansson, Kari (15); Jarvelin, Marjo-Riit ... (15); Uitterlinden, André ... (15); McCarthy, Mark I (14); Ingelsson, Erik (14); Thorsteinsdottir, Un ... (14); Gieger, Christian (14); Metspalu, Andres (14); Wilson, James F. (14); van Duijn, CM (13); Salomaa, Veikko (13); Campbell, Harry (13); Rudan, Igor (13); Wareham, Nicholas J. (13); de Geus, Eco J. C. (13); Kaprio, Jaakko (13); Gyllensten, Ulf (13); Rivadeneira, Fernand ... (13); Hofman, A (12); Uitterlinden, AG (12); Martin, NG (12); Mohlke, Karen L (12); Ripatti, Samuli (12); Wichmann, H. Erich (12); Spector, Tim D. (12); Luan, Jian'an (12); Pramstaller, Peter P ... (12); Montgomery, Grant W. (12); Loos, Ruth J F (12); Perola, Markus (11); Soranzo, Nicole (11); Ferrucci, L (11); Ridker, Paul M. (11); Chasman, Daniel I. (11); Pedersen, Nancy L (11); Boehnke, Michael (11); Thorleifsson, Gudmar (11); Jarvelin, MR (11); Hicks, Andrew A. (11); Harris, Tamara B (11); visa färre...

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Språk: Engelska (46)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (27); Naturvetenskap (3); Samhällsvetenskap (1)

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