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Numrering	Referens	Omslagsbild	Hitta
1.	Boraxbekk, Carl-Johan, 1980-, et al. (författare) Investigating the influence of KIBRA and CLSTN2 genetic polymorphisms on cross-sectional and longitudinal measures of memory performance and hippocampal volume in older individuals 2015 Ingår i: Neuropsychologia. - : Elsevier BV. - 0028-3932 .- 1873-3514. ; 78, s. 10-17 Tidskriftsartikel (refereegranskat)abstract The variability of episodic memory decline and hippocampal atrophy observed with increasing age may partly be explained by genetic factors. KIBRA (kidney and brain expressed protein) and CLSTN2 (calsyntenin 2) are two candidate genes previously linked to episodic memory performance and volume of the hippocampus, a key memory structure. However, whether polymorphisms in these two genes also influence age-related longitudinal memory decline and hippocampal atrophy is still unknown. Using data from two independent cohorts, the Sydney Memory and Ageing Study and the Older Australian Twins Study, we investigated whether the KIBRA and CLSTN2 genetic polymorphisms (rs17070145 and rs6439886) are associated with episodic memory performance and hippocampal volume in older adults (65–90 years at baseline). We were able to examine these polymorphisms in relation to memory and hippocampal volume using cross-sectional data and, more importantly, also using longitudinal data (2 years between testing occasions). Overall we did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in two cohorts of older adults.
2.	Cadar, Dorina, et al. (författare) Is education a demographic dividend? The role of cognitive reserve in dementia-related cognitive decline: a comparison of six longitudinal studies of ageing 2015 Ingår i: The Lancet. - : Elsevier. - 0140-6736. ; 386:Supplement 2 Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract BackgroundEducation, a marker for cognitive reserve, is thought to be associated with low risks of dementia, but less is known about its association with cognitive decline in preclinical stages of dementia. This study aimed to see whether higher education level could have a protective effect against faster cognitive decline in preclinical stages of dementia and whether this protection is consistent across six different studies around the world.

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Typ av publikation: tidskriftsartikel (1); konferensbidrag (1)

Typ av innehåll: övrigt vetenskapligt/konstnärligt (1); refereegranskat (1)

Författare/redaktör: Brodaty, Henry (2); Kochan, Nicole (2); Reppermund, Simone (2); Sachdev, Perminder (2); Aartsen, Marja (1); Thalamuthu, Anbupala ... (1); visa fler...; Schofield, Peter (1); Johansson, Boo (1); Ames, David (1); Hofer, Scott M (1); Boraxbekk, Carl-Joha ... (1); Lee, Teresa (1); Stephan, Blossom C. ... (1); Wen, Wei (1); Armstrong, Nicola (1); Kwok, John (1); Wright, Margaret (1); Trollor, Julian (1); Mather, Karen (1); Cadar, Dorina (1); Jagger, Carol (1); Piccinin, Andrea M. (1); Muniz-Terrera, Graci ... (1); Sharma, Nikhil (1); Dufouil, Carole (1); den Elzen, Wendy P. ... (1); Gussekloo, Jacobijn (1); Huisman, Martijn (1); Deeg, Doorly (1); visa färre...

Lärosäte: Göteborgs universitet (1); Umeå universitet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År: 2015 (2)Ta bort avgränsningen

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