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Common variation at 10p12.31 near MLLT10 influences meningioma risk
- Dobbins, Sara E. (author)
- Broderick, Peter (author)
-
- Melin, Beatrice (author)
- Umeå universitet,Onkologi
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- Johansen, Christoffer (author)
- Schramm, Johannes (author)
- Olver, Bianca (author)
- Lloyd, Amy (author)
- Ma, Yussanne P. (author)
- Hosking, Fay J. (author)
- Schoemaker, Minouk J. (author)
- Hepworth, Sarah J. (author)
- Hoffmann, Per (author)
- Muehleisen, Thomas W. (author)
- Noethen, Markus M. (author)
- Moebus, Susanne (author)
- Eisele, Lewin (author)
- Kosteljanetz, Michael (author)
- Muir, Kenneth (author)
- Swerdlow, Anthony (author)
- Simon, Matthias (author)
- Houlston, Richard S. (author)
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- (creator_code:org_t)
- 2011-07-31
- 2011
- English.
- In: Nature Genetics. - London : Nature America, Inc.. - 1061-4036 .- 1546-1718. ; 43:9, s. 825-827
- Journal article (peer-reviewed)
Abstract
Subject headings
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- To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- Dobbins, Sara E.
- Broderick, Peter
- Melin, Beatrice
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- Olver, Bianca
- Lloyd, Amy
- Ma, Yussanne P.
- Hosking, Fay J.
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- Ahlbom, Anders
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- Hepworth, Sarah ...
- Hoffmann, Per
- Muehleisen, Thom ...
- Noethen, Markus ...
- Moebus, Susanne
- Eisele, Lewin
- Kosteljanetz, Mi ...
- Muir, Kenneth
- Swerdlow, Anthon ...
- Simon, Matthias
- Houlston, Richar ...
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- NATURAL SCIENCES
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- Umeå University
- Karolinska Institutet
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