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- Bunk, Richard, et al.
(author)
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Guiding molecular motors with nano-imprinted structures
- 2005
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In: Japanese Journal of Applied Physics. - 0021-4922. ; 44:5A, s. 3337-3340
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Journal article (peer-reviewed)abstract
- This work, for the first time, demonstrates that nano-imprinted samples, with 100 nm wide polymer lines, can act as guides for molecular motors consisting of motor proteins actin and myosin. The motor protein function was characterized using fluorescence microscopy and compared to actomyosin motility on non-structured nitrocellulose surfaces. Our results open for further use of the nano-imprint technique in the production of disposable chips for bio-nanotechnological applications and miniaturized biological test systems. We discuss how the nano-imprinted motor protein assay system may be optimized and also how it compares to previously tested assay systems involving low-resolution UV-lithography and low throughput but high-resolution electron beam lithography.
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- Carlberg, Patrick
(author)
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Development of Nanoimprint Lithography for Applications in Electronics, Photonics and Life-sciences
- 2007
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Doctoral thesis (other academic/artistic)abstract
- This thesis describes different aspects of nanotechnology manufacturing with nanoimprint lithography (NIL), a relatively new nanofabrication tool capable of high resolution and high throughput. Surface structure creation with NIL is based on mechanical deformation of the patterning material. This is radically different from the two main established methods, ultra violet lithography (UVL) and electron beam lithography (EBL), which rely on chemical modification of the patterning media. The thesis is divided into two main parts, the first of which discusses process related issues and the second describes applications. Thus the initial discussion concerns production of stamps, perhaps the most important part of a working imprint technology. Aspects such as choice of materials, patterning methods, implications of structure layout and anti-sticking that have been used or developed in my work are described. The chapter on process outlines details concerning imprint related issues for different substrate materials and polymers and how these impact imprint parameters. The chapters on applications give a short introduction to each of them, and cover life-science, sensors, electronic devices and material research. However, the emphasis is on imprint related issues of the work, since this was my part of the projects. In the biological applications it is shown that nanoimprint patterned polymers are biocompatible and can be used to guide axon growth or create directional movement of motor proteins. In the following chapter imprint and a lift-off process is used to make interdigitated array electrodes for electrochemistry and cantilever sensors. It is shown that NIL can pattern both large area structures (contact pads) and nanometer structures in one single-step process. The electronic devices are made in III-V material and imprint is used to create an etch mask for a wet etch process. We show that the imprinted structures have properties similar to those made by EBL and thus that the electronic properties are not affected by the high pressure and temperature of the imprint process. In the last chapter we show using nanoimprint and a lift-off process that imprint can be used to position metal particles on a surface, which in turn may function as catalytic particles for growing nanowires.
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| 6. |
- Johansson, Fredrik I, et al.
(author)
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Axonal outgrowth on nano-imprinted patterns
- 2006
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In: Biomaterials. - : Elsevier BV. - 1878-5905 .- 0142-9612. ; 27:8, s. 1251-1258
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Journal article (peer-reviewed)abstract
- Nanotechnology has provided methods to fabricate surface patterns with features down to a few rim. If cells or cell processes exhibit contact guidance in response to such small patterns is an interesting question and could be pertinent for many applications. In the present study we investigated if axonal outgrowth was affected by nano-printed patterns in polymethylmethacrylate (PMMA)-covered silicon chips. To this end adult mouse sympathetic and sensory ganglia were mounted in Matrigel (R) on the chips close to the nano-patterns. The patterns consisted of parallel grooves with depths of 300 nm and varying widths of 100-400 nm. The distance between two adjacent grooves was 100-1600 nm. The chips were cultured in medium containing 25 ng/ml of nerve growth factor to stimulate axonal outgrowth. After 1 week of incubation. axonal outgrowth was investigated by immunocytochemistry or scanning electron microscopy. Axons displayed contact guidance on all patterns. Furthermore, we found that the nerve cell processes preferred to grow on ridge edges and elevations in the patterns rather than in grooves, a seemingly claustrophobic behavior. We conclude that axons of peripheral neurons might be guided by nanopatterns on PMMA when the lateral features are 100 nm or larger. The present results can be utilized for nerve regenerating scaffolds or the construction of a stable, high-resolution electronic interface to neurons, which is required for future brain machine interfaces. (c) 2005 Elsevier Ltd. All rights reserved.
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| 7. |
- Koksharov, Yu.A., et al.
(author)
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Magnetostatic interactions in planar ring-like nanoparticle structures
- 2006
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In: Thin Solid Films. - : Elsevier BV. - 0040-6090. ; 515, s. 731-734
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Journal article (peer-reviewed)abstract
- Numerical calculations of equilibrium state energies and local magnetic fields in planar ring-like nanoparticle structures were performed. The dipole–dipole, Zeeman and magnetic anisotropy interactions were included into the model. The result of their competition depends on the value of the external magnetic field, magnetic parameters of an individual nanoparticle, size and shape of the structures. Flux-closed vortexes, single domain, two- domain ‘‘onion’’-like, ‘‘hedgehog’’-like and more complex spin structures can be realized. The critical field, providing a sharp transition from the flux-closed vortex to the ‘‘onion’’-like state, can be regulated by a variation of the particle magnetization and anisotropy constant, their easy directions, and particle space arrangement.
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