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1.	Li, J, et al. (author) Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells 2015 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 6804- Journal article (peer-reviewed)
2.	Bonilla, FA, et al. (author) International Consensus Document (ICON): Common Variable Immunodeficiency Disorders 2016 In: The journal of allergy and clinical immunology. In practice. - : Elsevier BV. - 2213-2201 .- 2213-2198. ; 4:1, s. 38-59 Journal article (peer-reviewed)
3.	Friman, Vanda, 1952, et al. (author) Secondary immunodeficiency in lymphoproliferative malignancies 2016 In: Hematological Oncology. - : Wiley. - 0278-0232 .- 1099-1069. ; 34:3, s. 121-132 Journal article (peer-reviewed)abstract Secondary immunodeficiencies occur as a consequence of various diseases, including hematological malignancies, and the use of pharmacological therapies, such as immunosuppressive, anti-inflammatory, and biological drugs. Infections are the main cause of morbidity and mortality in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients. Recent advances in treatment have prolonged the duration of remission and the time between relapse phases in MM and CLL patients. However, managing multiple relapses and the use of salvage therapies can lead to cumulative immunosuppression and a higher risk of infections. The pathogenesis of immune deficiency secondary to lymphoproliferative malignancy is multifactorial including disease- and treatment-related factors. Supportive treatment, including early vaccination, anti-infective prophylaxis, and replacement immunoglobulin, plays a key role in preventing infections in MM and CLL. This article provides an overview of the basic immunology necessary to understand the pathogenesis of secondary immunodeficiency and the infectious complications in MM and CLL. We also discuss the evidence supporting the role of prophylactic replacement immunoglobulin treatment in patients with antibody failure secondary to MM and CLL and the indications for its use. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Chapel, H (3); Hammarstrom, L (2); Cunningham-Rundles, ... (2); Warnatz, K (2); Li, J. (1); Ellinghaus, E. (1); show more...; Aukrust, P. (1); Perez, E. (1); Elder, JT (1); Nair, RP (1); Karlsen, TH (1); Sullivan, KE (1); Orange, JS (1); Franke, A (1); Padyukov, L (1); Witte, T (1); Nothen, MM (1); Nonoyama, S (1); Tang, MLK (1); Pandey, R. (1); Folseraas, T (1); Lieb, W (1); Schreiber, S (1); Winqvist, O (1); Gieger, C (1); Hakonarson, H (1); Brand, S (1); Buning, C (1); Winkelmann, J (1); Friman, Vanda, 1952 (1); Blimark, Cecilie (1); Costa-Carvalho, BT (1); Quinti, I (1); Bonilla, FA (1); Barlan, I (1); de la Morena, MT (1); Espinosa-Rosales, FJ (1); Routes, JM (1); Grimbacher, B (1); Langerbeins, P (1); Fevang, B (1); Salzer, U (1); Atschekzei, F (1); Goldacker, S (1); Dhalla, F. (1); Schmidt, RE (1); Videm, V (1); Jorgensen, SF (1); Maggadottir, SM (1); Bakay, M (1); show less...

University: Karolinska Institutet (3); University of Gothenburg (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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