| 1. |
- Berger, Ashton C, et al.
(author)
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A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
- 2018
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In: Cancer Cell. - : Elsevier BV. - 1535-6108 .- 1878-3686. ; 33:4, s. 690-705.e9
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Journal article (peer-reviewed)abstract
- We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.
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| 2. |
- Gong, Y., et al.
(author)
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On the breakaway oxidation of Fe9Cr1Mo steel in high pressure CO2
- 2017
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In: Acta Materialia. - : Elsevier Ltd. - 1359-6454 .- 1873-2453. ; 130, s. 361-374
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Journal article (peer-reviewed)abstract
- Fundamental insights into the mechanism of breakaway oxidation in Fe9Cr1Mo steel are deduced, through advanced characterisation and modelling. Degradation at 600 °C/∼42 bar CO2 for ∼20,000 h is emphasised: conditions relevant to components such as the finned superheater tubes used for advanced gas-cooled nuclear reactors. It is shown that such conditions are sufficient to cause carbon saturation of the metallic substrate, as confirmed by direct observation of extensive carbide precipitation but also numerical analysis of the carbon transport. Thus the observation of graphite precipitation close to the scale/metal interface is rationalised. Nonetheless, the activity of carbon at the scale/metal interface does not reach unity – with respect to graphite – at time zero. A modelling method is proposed which accounts for this kinetic retardation of the attack; this can be used to interpolate across the regimes within which breakaway oxidation is prevalent. It is a plausible model for extrapolation to the lower temperatures relevant to service conditions and is suitable for lifetime estimation – so-called ‘remnant life analysis’ – of such safety-critical components when prone to this form of attack.
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| 3. |
- Ying, Z., et al.
(author)
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Antenna design for diversity and MIMO application
- 2016
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In: Handbook of Antenna Technologies. - Singapore : Springer. - 9789814560443 - 9789814560436 ; , s. 1479-1530
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Book chapter (peer-reviewed)abstract
- Recently, multiple-input multiple-output (MIMO) technology and diversity have attracted much attention both in industry and academia due to high data rate and high spectrum efficiency. By increasing the number of antennas at the transmitter and/or the receiver side of the wireless link, the diversity/MIMO techniques can increase wireless channel capacity without the need of additional power or spectrum in rich scattering environments. However, due to limited space of small mobile devices, the correlation coefficients between MIMO antenna elements are usually very high, and the total efficiencies of MIMO elements would be degraded severely due to mutual couplings. In addition, the human body causes high losses on electromagnetic waves. In real applications, the presence of users may result in significant reduction of total antenna efficiencies, and the correlations of MIMO antenna systems are also highly affected. In this chapter, the performance of some basic MIMO antennas as well as recent technologies to improve MIMO antenna performance of portable devices and mobile terminals are reviewed. The interactions between MIMO antennas and human body are also addressed particularly in mobile terminals application.
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